Daneshvar Medicine

Daneshvar Medicine

Effect of diminazene on cardiac hypertrophy through improving hyperlipidemia in D-galactose-induced aging rats

Document Type : Original Article

Authors
Ali Mohammadi 1
Farnaz Fariba 2
Siamak Shahidi 3
Abdolrahman Sarihi 4
Fatemeh Ramezani-Aliakbari 3
1 Medical School, Hamadan University of Medical Sciences, Hamadan, Iran
2 Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3 Department of Physiology, School of medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4 Department of Neuroscience, School of Sciences and Advanced Technology in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
10.22070/daneshmed.2024.18851.1472
Abstract
Background and Objective: Aging plays an important role in cardiovascular diseases. Diminazine is an animal anti-infective drug that has protective effects on cardiovascular diseases. This study aimed to investigate the possible cardio-protective effects of Diminazine in aged rats induced by D-galactose through improving lactate dehydrogenase (LDH), and cardiac creatine kinase (CK-MB), and lipid profile.
Materials and Methods: 20 male Wistar rats were divided equally into control, Diminazine (DIZE), D-galactose (D-GAL), and D-GAL+DIZE groups. Cardiac hypertrophy was measured. Serum levels of lipid profile and cardiac damage markers were also measured.
Results: Aging caused dyslipidemia with cardiac hypertrophy and significant increases in serum LDH, and CK-MB. Diminazine treatment of aged rats induced significant improvements in cardiac hypertrophy and cardiac markers. This could be explained by the ability of Diminazine to improve triglyceride (TG), very low density lipoprotein (VLDL), and high density lipoprotein (HDL) levels.
Conclusion: Diminazine exerts a cardio-protective effect in aging, mainly by improving cardiac hypertrophy and dyslipidemia.
Keywords
Aging
Diminazine
Heart
Hypertrophy
Subjects
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Daneshvar Medicine
Volume 32, Issue 2 - Serial Number 171
July and August 2024
Pages 86-97