Document Type : Original Article
Authors
1
Medical School, Hamadan University of Medical Sciences, Hamadan, Iran
2
Department of Cardiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
3
Department of Physiology, School of medicine, Hamadan University of Medical Sciences, Hamadan, Iran
4
Department of Neuroscience, School of Sciences and Advanced Technology in Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
5
Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran
10.22070/daneshmed.2024.18851.1472
Abstract
Background and Objective: Aging plays an important role in cardiovascular diseases. Diminazine is an animal anti-infective drug that has protective effects on cardiovascular diseases. This study aimed to investigate the possible cardio-protective effects of Diminazine in aged rats induced by D-galactose through improving lactate dehydrogenase (LDH), and cardiac creatine kinase (CK-MB), and lipid profile.
Materials and Methods: Twenty male Wistar rats were divided equally into control, Diminazine (DIZE), D-galactose (D-GAL), and D-GAL+DIZE groups. Cardiac hypertrophy was measured. Serum levels of lipid profile and cardiac damage markers were measured.
Results: Aging caused dyslipidemia with cardiac hypertrophy and significant increases in serum LDH, and CK-MB. Diminazine treatment of aged rats induced significant improvements in cardiac hypertrophy and cardiac markers; this could be explained by the ability of Diminazine to improve triglyceride (TG), very low density lipoprotein (VLDL), and high density lipoprotein (HDL) levels.
Conclusion: Diminazine exerts a cardio-protective effect in aging, mainly by improving cardiac hypertrophy and dyslipidemia.
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