Daneshvar Medicine

Daneshvar Medicine

Response of plasma levels of Irisin, Follistatin and FGF21 to aerobic exercise in women recovered from Covid-19

Document Type : Original Article

Authors
Parisa Amiri farsani 1
Farshad Ghazalian 1
Sara Mobarak 2
Esmat Radmanesh 3
Mandana Gholami 1
1 Department of Physical Education and Sports Sciences, Science and Research Unit, Islamic Azad University, Tehran, Iran
2 Department of Infectious Diseases, University of Medical Sciences, Abadan, Iran
3 Department of Physiology, University of Medical Sciences, Abadan, Iran
10.22070/daneshmed.2023.17706.1350
Abstract
Background and Objective: Recently, performing regular sports activities due to the release of Myokines has been considered as a suitable strategy for rehabilitation, control of complications and consequences related to Covid-19. The purpose of this study was to investigate the response of plasma levels of Irisin, Follistatin and FGF21 to aerobic training in women recovered from Covid-19.
Materials and Methods: 22 women recovered from Covid-19 in Abadan and Khorramshahr cities were divided into two groups of 11 people, including the aerobic exercise group and the control group, after a general call and selection. The aerobic exercise group performed the exercise protocol with an intensity of 50 to 70% of the reserve heart rate for eight weeks (three sessions per week). Before and after the end of the training protocol, blood samples were collected and Irisin, Follistatin and FGF21 levels were measured by ELISA method. The data were analyzed using the statistical test of covariance (ANCOA) at p<0.05.
Results: Based on the comparison of data between the groups, values of Irisin (P<0.05), Follistatin (P<0.05) and FGF21 (P<0.05) in the aerobic group significantly increased as compared to the control group. Also, intragroup changes of Irisin (P<0.05), Follistatin (P<0.05) and FGF21 (P<0.05) also showed that there is a significant increase between the average before and after the aerobic group.
Conclusion: Performing aerobic exercises in women recovered from Covid-19 can be effective in restoring their Myokine profile
Keywords
Covid-19
Irisin
Follistatin
FGF21
  1. Gorskaya Yu F, Semenova EN, Nagurskaya EV, Bekhalo VA, Nesterenko VG. Apoptosis and P53 Activation are involved in COVID-19 Pathogenesis. COVID-19 Pandemic: Case Studies & Opinions. 2021; 2(2): 208–213.
  2. Bo W, Xi Y, Tian Z. The role of exercise in rehabilitation of discharged COVID-19 patients. Sports Medicine and Health Science. 2021; 3(4): 194–201.
  3. Gurovich AN, Tiwari S, Kehl S, Umucu E, Peñailillo L. A Novel “Eccentric” Therapeutic Approach for Individuals Recovering From COVID-19. Cardiopulmonary Physical Therapy Journal. 2021; Vol (32): S15-S21.
  4. Filgueira TO, Castoldi A, Santos LER, De Amorim GJ, De Sousa Fernandes MS, Anastácio W de L do N, et al. The Relevance of a Physical Active Lifestyle and Physical Fitness on Immune Defense. Frontiers in Immunology. 2021; Vol (12).
  5. Yalcin M, Kocak E, Kacar M. The Role of Exercise as a Treatment and Preventive Strategy during Covid-19 Pandemic. Anatolian Clinic Journal of Medical Sciences. 2020; 25(1): 238–45.
  6. Nobari H, Fashi M, Eskandari A, Pérez-Gómez J, Suzuki K. Potential Improvement in Rehabilitation Quality of 2019 Novel Coronavirus by Isometric Training System; Is There “Muscle-Lung Cross-Talk”? International Journal of Environmental Research and Public Health. 2021; 18(12): 6304.
  7. Piccirillo R. Exercise-Induced Myokines With Therapeutic Potential for Muscle Wasting. Vol. 10, Frontiers in Physiology. 2019; Vol (10): 287.
  8. De Sousa RAL, Improta-Caria AC, Aras-Júnior R, de Oliveira EM, Soci ÚPR, Cassilhas RC. Physical exercise effects on the brain during COVID-19 pandemic: links between mental and cardiovascular health. Neurological Sciences. 2021; 42(4): 1325-1334.
  9. Aristizabal JP, Navegantes R, Melo E, Pereira A Jr. Use of Heart Rate Variability Biofeedback to Reduce the Psychological Burden of Frontline Healthcare Professionals Against COVID-19. Frontiers in psychology. 2020; 11: 572191.
  10. Jimeno-Almazán A, Pallarés JG, Buendía-Romero Á, Martínez-Cava A, Franco-López F, Sánchez-Alcaraz Martínez BJ, et al. Post-COVID-19 Syndrome and the Potential Benefits of Exercise. International Journal of Environmental Research and Public Health. 2021; 18(10): 5329.
  11. Catalano A. COVID-19: Could Irisin Become the Handyman Myokine of the 21st Century? Coronaviruses. 2020; 1 (1): 32-41.
  12. Ghanei, M., Shirvani, H., Roshani Koosha, M. S., Shakibaee, A., Arabzadeh, E. Exercise training and muscle–lung crosstalk: The emerging roles of Irisin and Semaphorin-3A in pulmonary diseases. Journal of Exercise & Organ Cross Talk. 2021; 1(1): 24-28.
  13. Ijiri N, Kanazawa H, Asai K, Watanabe T, Hirata K. Irisin, a newly discovered myokine, is a novel biomarker associated with physical activity in patients with chronic obstructive pulmonary disease. Official Journal of the Asian Pacific Sociely of Respirology. 2015; 20(4): 612-617.
  14. Benassi R, Da Silva DD, Da Silva Nogueira ER, Da Silva EP, De Oliveira JD, Da Silva Manhaes T, Paulino ED, De Magalhães Neto AM, Gonçalves LC. Irisin and effects on cardiometabolic diseases in physical conditioning and treatment of covid-19. World Journal of Pharmacy and Pharmaceutical Sciences. 2021; 10(2): 76-87.
  15. Taheri F, Fathi M, Hejazi K. The Effect of 10 Weeks Core Muscle Training on Levels of Follistatin, Myostatin, and Pain in Elderly Women. Quarterly of the Horizon of Medical Sciences. 2021; 27(2): 164-181.
  16. Attarzadeh Hosseini S R, Motahari Rad M, Moien Neia N. The effect of two different intensities resistance training on muscle growth regulatory myokines in sedentary young women. Arak Medical University Journal. 2016; 19 (7):56-65. [Persian]
  17. Steenblock C, Schwarz PEH, Ludwig B, Linkermann A, Zimmet P, Kulebyakin K, et al. COVID-19 and metabolic disease: mechanisms and clinical management. Lancet Diabetes Endocrinol. 2021; 9(11): 786-798.
  18. Yan J, Nie Y, Cao J, Luo M, Yan M, Chen Z, et al. The Roles and Pharmacological Effects of FGF21 in Preventing Aging-Associated Metabolic Diseases. Frontiers in Cardiovascular Medicine. 2021; Vol (8): 655575.
  19. Leal LG, Lopes MA, Batista ML Jr. Physical Exercise-Induced Myokines and Muscle-Adipose Tissue Crosstalk: A Review of Current Knowledge and the Implications for Health and Metabolic Diseases. Frontiers in Physiolog. 2018; Vol (9): 1307.
  20. Qi D, Yan X, Xiang J, Peng J, Yu Q, Tang X, et al. Effects of Early Physical and Pulmonary Rehabilitation for Severely and Critically ill COVID-19 Patients. Research Square. 2020; Vol (1): 1-17.
  21. Leustean L, Preda C, Teodoriu L, Mihalache L, Arhire L, Ungureanu MC. Role of Irisin in Endocrine and Metabolic Disorders—Possible New Therapeutic Agent? Applied Sciences. 2021; 11 (12): 5579.
  22. Amanat S, Sinaei E, Panji M, MohammadporHodki R, Bagheri-Hosseinabadi Z, Asadimehr H, Fararouei M, Dianatinasab A. A Randomized Controlled Trial on the Effects of 12 Weeks of Aerobic, Resistance, and Combined Exercises Training on the Serum Levels of Nesfatin-1, Irisin-1 and HOMA-IR. Frontiers in Physiology. 2020; Vol (11):562895.
  23. Khosravianfar M, Jalali dehkordi K, Sharifi G, jalali dehkordi A. Comparison of the effect of period of resistance, aerobic and concurrent training on irisin, CRP serum levels in obese women. Journal of Shahrekord University Medical Sciences. 2018; 20 (2):13-23. [Persian]
  24. Nazar Ali P, Ansari Ghadim R, Rahmani H. The effect of high-intensity circular exercises on high serpentine serum levels and insulin resistance in inactive women with overweight. J Endocrine Metabol Iran. 2018; 10(40): 149-62. [Persian]
  25. Nigro E, Polito R, Alfieri A, Mancini A, Imperlini E, Elce A, Krustrup P, Orrù S, Buono P, Daniele A. Molecular mechanisms involved in the positive effects of physical activity on coping with COVID-19. European journal of applied physiology. 2020; 120 (12): 2569–2582.
  26. Dianatinasab A, Koroni R, Bahramian M, Bagheri-Hosseinabadi Z, Vaismoradi M, Fararouei M, Amanat S. The effects of aerobic, resistance, and combined exercises on the plasma irisin levels, HOMA-IR, and lipid profiles in women with metabolic syndrome. Journal of exercise science and fitness. 2020; 18 (3): 168–176.
  27. Huh JY, Dincer F, Mesfum E, Mantzoros CS. Irisin stimulates muscle growth-related genes and regulates adipocyte differentiation and metabolism in humans. International Journal of Obesity. 2014; 38 (12): 1538-44.
  28. Norheim F, Langleite TM, Hjorth M, Holen T, Kielland A, Stadheim HK, Gulseth HL, Birkeland KI, Jensen J, Drevon CA. The effects of acute and chronic exercise on PGC-1α, irisin and browning of subcutaneous adipose tissue in humans. FEBS Journal. 2014; 281(3): 739-49.
  29. Aghabagi E, Ghanbar Zadeh M, Ranjbar R. The effect of 8 weeks endurance and resistance training on Myostatin and Follistatin serum level in postmenopausal women’ Journal of Advanced Pharmacy Education & Research. 2020; 10 (S4): 63–69.
  30. Shajiei A, Rashidlamir A, Khajei R, Ramzan Pour M. The effect of eight weeks of a blinded clinical trial of aerobic exercise with green coffee consumption on plasma levels of follistatin and myostatin in Overweight non-athletic women. Journal of Neyshabur Faculty of Medical Sciences. 2020; 7 (4): 104–119.
  31. Tajik M, Rashidlamir A, Attarzadeh Hosseini R. The Effect of an 8-week Aerobic Training and Weight-loss Diet on the Level of Serum Follistatin in Inactive Middle-aged Women. 2015; 23 (5): 411-419. [Persian]
  32. Taheri F, Fathi M, Hejazi K. The Effect of 10 Weeks Core Muscle Training on Levels of Follistatin, Myostatin, and Pain in Elderly Women. Quarterly of The Horizon of Medical Sciences. 2021; 27(2): 164-180. [Persian]
  33. shirzad J, Tofighi A, Tolouei Azar J, khadem Ansari M. H. Adaptation of Irisin, Follistatin and Myostatin to 8 weeks of Resistance, Endurance and Concurrent Training in Obese Men. Sport Physiology & Management Investigations. 2021; 12(4): 23-41 [Persian]
  34. Chapman MA, Arif M, Emanuelsson EB, Reitzner SM, Lindholm ME, Mardinoglu A, Sundberg CJ. Skeletal Muscle Transcriptomic Comparison between Long-Term Trained and Untrained Men and Women. Cell Reports. 2020; 31(12): 107808.
  35. McPherron AC, Lawler AM, Lee SJ. Regulation of skeletal muscle mass in mice by a new TGF-beta superfamily member. Nature. 1997; 387(6628): 83-90.
  36. Domin R, Dadej D, Pytka M, Zybek-Kocik A, Ruchała M, Guzik P. Effect of Various Exercise Regimens on Selected Exercise-Induced Cytokines in Healthy People. Int J Environ Res Public Health. 2021; 18(3): 1261.
  37. Burtscher J, Millet GP, Burtscher M. Low cardiorespiratory and mitochondrial fitness as risk factors in viral infections: implications for COVID-19. Br J Sports Med. 2021; 55(8): 413-415.
  38. El Assar M, Álvarez-Bustos A, Sosa P, Angulo J, Rodríguez-Mañas L. Effect of Physical Activity/Exercise on Oxidative Stress and Inflammation in Muscle and Vascular Aging. International Journal of Molecular Sciences. 2022; 23(15): 8713.
  39. AbdelMassih A.F, Menshawey R, Hozaien R, Kamel A, Mishriky F, Husseiny R, et al. The potential use of lactate blockers for the prevention of COVID-19 worst outcome, insights from exercise immunology. Medical hypotheses. 2021; Vol (148): 110520.
  40. Kolali A, Radfar B. Khayami K, Khayami H. The effect of spirulina supplement along with aerobic exercise on the changes of myostatin, follistatin and fat mass of overweight middle-aged peopl. Gorgan The 5th National Sports Physiology and Biochemistry Conference. 2020. https://civilica.com/doc/1356288 [Persian]
  41. Esazadeh L, Hosseini Kakhk A, Khajeie R, Hejazi S. M. The Effect of Concurrent Training Order (Resistance-Aerobic) on Some Factors of Physical Fitness, Functional Capacity and Serum Levels of Myostatin and Follistatin Hormones in Postmenopausal Women (Clinical Trial). Journal of Sport Biosciences. 2020; 12(2): 189-206.
  42. Steenblock C, Schwarz PEH, Ludwig B, Linkermann A, Zimmet P, Kulebyakin K, et al. COVID-19 and metabolic disease: mechanisms and clinical management. Lancet Diabetes Endocrinol. 2021; 9(11): 786-798.
  43. Fereidoonfara KH, Monazzami AA, Rahimi Z and Rahimi MA. The effect of eight weeks of resistance training on the serum concentration of beta-klutho proteins and fibroblast growth factor 12 in diabetic women with non-alcoholic fatty liver disease. Iranian Journal of Physiology and Pharmacology. 2020; 4(1 and 2): 39-48. [Persian]
  44. Gaich G, Chien JY, Fu H, Glass LC, Deeg MA, Holland WL, et al. The effects of LY2405319, an FGF21 analog, in obese human subjects with type 2 diabetes. Cell metabolism. 2013; 18(3): 333-40.
  45. Vizvari E, Farzanegi P, Abbas zade H. Effect of Moderate Aerobic Exercise on Serum Levels of FGF21 and Fetuin A in Women with Type 2 Diabete. Medical Laboratory Journa. 2020; 14(6): 17-22. [Persian]
  46. Vizvari E, Farzanegi P, Abbas Zade Sourati H. Effect of Vigorous Aerobic Exercise on Serum Levels of SIRT1, FGF21 and Fetuin A in Women with Type II Diabetes. Medical Laboratory Journa. 2018; 12 (2):1-6 [Persian]
  47. Abbassi Daloii A, Maleki Delarestaghi A. The Effect of Aerobic Exercise on Fibroblast Growth Factor 21 and Adiponectin in Obese Men. Journal of Sport Biosciences. 2017; 9(1):109-121. [Persian]
  48. Files DC, Sanchez MA, Morris PE. A conceptual framework: the early and late phases of skeletal muscle dysfunction in the acute respiratory distress syndrome. Critical Care. 2015. 2015; 19(1): 266.
  49. Suzuki, K.; Hekmatikar, A.H.A.; Jalalian, S.; Abbasi, S.; Ahmadi, E.; Kazemi, A.; Ruhee, R.T.; Khoramipour, K.The Potential of Exerkines in Women’s COVID-19: A New Idea for a Better and More Accurate Understanding of the Mechanisms behind Physical Exercise. International Journal Environmental Research and Public Health. 2022; 19(23): 15645.
  50. Soares MN, Eggelbusch M, Naddaf E, Gerrits KHL, Van der Schaaf M, Van den Borst B, Wiersinga WJ, Van Vugt M, Weijs PJM, Murray AJ, Wüst RCI. Skeletal muscle alterations in patients with acute Covid-19 and post-acute sequelae of Covid-19. Journal of Cachexia, Sarcopenia and Muscle. 2022; 13(1): 11-22.
Daneshvar Medicine
Volume 31, Issue 3 - Serial Number 166
September and October 2023
Pages 55-67