The effects of concurrent training and calorie restriction on anti-inflammatory adipokines and insulin sensitivity in obese women with fatty liver

Document Type : Original Article

Authors

Department of Exercise Physiology, Faculty of Humanities, Ilam Branch, Islamic Azad University, Ilam, Iran

Abstract

Background and Objective: Disturbance in the regulation of secretion between inflammatory and anti-inflammatory adipokines can lead to insulin resistance and type 2 diabetes. The aim of the present study was to investigate the effects of concurrent training, calorie restriction and concurrent training+ calorie restriction on the levels of anti-inflammatory adipokines and insulin sensitivity in obese women with non-alcoholic fatty liver disease.
Materials and Methods: Thirty seven women with non-alcoholic fatty liver were randomly divided into four groups: control (n=9), calorie restriction (n=9), concurrent training (n=9) and concurrent training+ calorie restriction (n=10). Training protocol included combination of aerobic with 40-60 percent of heart rate reserve and resistance training 40-60 percent of 1 repetition maximum (1RM), eight weeks and three sessions per week. The calorie restriction groups, alleviate 400 to 500 kcal/day from total daily calorie intake. Blood samples were taken pre- and post intervention. For statistical analysis, paired samples t-test and analysis of covariance at a significant level of p<0.05 were used.
Results: Concurrent training+ calorie restriction significantly increased serum adiponectin and adipolin concentration compared to the caloric restriction and control groups (both, p<0.026) and the insulin sensitivity index compared to the control group (p=0.027). Also, there was a significant increase in serum adiponectin and adipolin concentration and insulin sensitivity index of the concurrent training group compared to the control group (p<0.05). In the calorie restriction group, only the insulin sensitivity index increased significantly compared to the pre-test (p=0.004).
Conclusion: It seems that performing concurrent training alone and with calorie restriction is a more effective intervention in increasing anti-inflammatory adipokines and improving insulin sensitivity than calorie restriction alone.

Keywords

Main Subjects

References

  1. Lizcano F, Guzmán G. Estrogen deficiency and the origin of obesity during menopause. Biomed Research Intertational 2014;2014:757461.
  2. Roman AA, Parlee SD, Sinal CJ. Chemerin: a potential endocrine link between obesity and type 2 diabetes. Endocrine 2012;42(2):243-51.
  3. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nature Reviews Immunology 2011;11(2):85-97.
  4. Shoelson SE, Lee J, Goldfine AB. Inflammation and insulin resistance. The Journal of Clinical Investigation 2006;116(7):1793-801.
  5. Galic S, Oakhill JS, Steinberg GR. Adipose tissue as an endocrine organ. Molecular and Cellular Endocrinology 2010;316:129-39.
  6. Cnop M, Havel PJ, Utzschneider KM, Carr DB, Sinha MK, Boyko EJ, et al. Relationship of adiponectin to body fat distribution, insulin sensitivity and plasma lipoproteins: evidence for independent roles of age and sex. Diabetologia 2003;46:459-69.
  7. Liu Z, Liang S, Que S, Zhou L, Zheng S, Mardinoglu A. Meta-Analysis of Adiponectin as a Biomarker for the Detection of Metabolic Syndrome. Frontiers in Physiology 2018;9:1238.
  8. Engin A. Adiponectin-Resistance in Obesity. Advances in Experimental Medicine and Biology 2017;960:415-41.
  9. Ahmadi A, Ghanbarzadeh M, Ranjbar R, Nikbakht M. Effects of eight Weeks of Aerobic exercise on leptin to adiponectin ratio and glycemic control indices in men with type two diabetes. Sport Physiology 2021;13(51):93-116.
  10. Ghorbani GZ, Gholami M, Nikbakht H. effect of resistance training with different intensities on adiponectin and lipid profiles in overweight women. Scientific Journal of Rehabilitation Medicine 2020;8:47-55.
  11. Safari S, Raiesifar A, Raiesifar Z, Shirzadegan R. The Effect of a combined training course on the level of leptin, adiponectin, and insulin plasma in obese man's workers in the health network of Poldokhtar. Zanko Journal of Medicine Science 2020;20:50-62.
  12. Mohammad Rahimi GR, Bijeh N, Rashidlamir A. Effects of exercise training on serum preptin, undercarboxylated osteocalcin and high molecular weight adiponectin in adults with metabolic syndrome. Experimental Physiology 2020;105:449-59.
  13. Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, et al. Adipolin/ C1qdc2/ CTRP12 protein functions as an adipokine that improves glucose metabolism. The Journal of Biological Chemistry 2011;286(40):34552–8.
  14. Wei Z, Peterson JM, Lei X, Cebotaru L, Wolfgang MJ, Baldeviano GC, et al. C1q/TNF-related protein-12 (CTRP12), a novel adipokine that improves insulin sensitivity and glycemic control in mouse models of obesity and diabetes. The Journal of Biological Chemistry 2012;287(13):10301–10315.
  15. Wei Z, Lei X, Seldin MM, Wong GW. Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity. The Journal of Biological Chemistry 2012;287(43):35804-14.
  16. Espandar N, Tofighi A, Tolouei Azar J, Khadem Ansari MH. The Effect of 8 Weeks of Resistance, Endurance, and Concurrent Training on Serum CTRP-12, Furin, KLF-15, Lipid Profiles and Insulin Resistance in Sedentary Obese Men. Sport Physiology 2021;13(49):107-36.
  17. Soori R, Asad MR, Barahoiejamar Z, Rezaian N. Effect of endurance training with two different intensities on serum levels of adipolin and some of its regulating factors in sedentary men. Journal of Sport and Exercise Physiology 2020;13(2):45-56.
  18. Rezaeian N, Ravasi AA, Soori R, Akbarnezhad A, Mirshafiey SA, Towfighi F. Effect of resistance training on serum levels of adipolin and insulin resistance in obese women. Journal of Sport Bioscience 2020;12(1):1-16.
  19. Jashni HK, Mohebbi H, Delpasand A, Jahromy HK. Caloric restriction and exercise training, combined, not solely improve total plasma adiponectin and glucose homeostasis in streptozocin-induced diabetic rats. Sport Science for Health 2014; 11: 81-6.
  20. Larson-Meyer DE, Newcomer BR, Heilbronn LK, Volaufova J, et al. Effect of 6-month calorie restriction and exercise on serum and liver lipids and markers of liver function. Obesity 2008;16:1355-1362.
  21. Speakman JR, Mitchell SE. Caloric restriction. Molecular Aspects of Medicine 2011;32:159-221.
  22. Lee S, Bacha F, Hannon T, Kuk JL, Boesch C, Arslanian S. Effects of aerobic versus resistance exercise without caloric restriction on abdominal fat, intrahepatic lipid, and insulin sensitivity in obese adolescent boys a randomized, controlled trial. Diabetes 2012;61:2787-95.
  23. Daly A, Franz M, Holzmeister LA, Kulkarni K, O'connell B, Wheeler M. New diabetes nutrition resources. Journal of the American Dietetic Association 2003;103(7):832-4.
  24. Brzycki M. Strength testing predicting a one rep max from reps- to- fatigue. Journal of physical education, recreation and dance 1993;68:88-90.
  25. Moradgholi E, Jafari M, Fathei M, hejazi K. The effect of high-intensity interval training on e-selectin and p- selectin in obese women. Iranian Journal of Endocrinology and Metabolism 2016;18(4): 279-28.
  26. Conte C, Epstein S, Napoli N. Insulin resistance and bone: A biological partnership. Acta Diabetologica 2018;55(4):305–14.
  27. Hemmatinafar M, Kordi MR, Choopani S, Choobineh S, Gharari Arefi R. the effect of high intensity interval training (HIIT) on plasma adiponectin levels, insulin sensitivity and resistance in sedentary young men. Journal of Advances in Medical and Biomedical Research 2013;21(84):1-12.
  28. Mohamadzadeh Larijan H, Nikravan A, Aeenparast A. The role of hospital intervention in prevention of diabetes in pre-diabetes patients. Payesh 2019;18:465-73.
  29. Ratliff JC, Mutungi G, Puglisi MJ, Volek JS, Fernandez ML. Eggs modulate the inflammatory response to carbohydrate restricted diets in overweight men. Nutrition and Metabolism (Lond) 2008;5:6.
  30. Puglisi MJ, Fernandez ML. Modulation of C-reactive protein, tumor necrosis factor-alpha, and adiponectin by diet, exercise, and weight loss. The Journal of Nutrition 2008;138(12):2293-6.
  31. Bougoulia M, Triantos A, Koliakos G. Effect of weight loss with or without orlistat treatment on adipocytokines, inflammation, and oxidative markers in obese women. Hormones Athens 2006;5(4):259.
  32. Kang JG, Park CY. Anti-Obesity Drugs: A review about their effects and safety. Diabetes and Metabolism Journal 2012;36(1):13-25.
  33. Madsen EL, Rissanen A, Bruun JM, Skogstrand K, Tonstad S, Hougaard DM, Richelsen B. Weight loss larger than 10% is needed for general improvement of levels of circulating adiponectin and markers of inflammation in obese subjects: a 3-year weight loss study. European Journal of Endocrinology 2008;158:179–87.
  34. Simpson KA, Singh MA. Effects of exercise on adiponectin: a systematic review. Obesity (Silver Spring) 2008;16:241–56.
  35. Galdavi R, Mogharnasi M, Nayebifar S. The effect of continuous training on plasma levels of adipolin, insulin sensitivity and body fat percent in overweight and obese women. Journal of Practical Studies of Biosciences in Sport 2022;10(21):42-52.
  36. Nardo LG, Rai R. Metformin therapy in the management of polycystic ovary syndrome: endocrine, metabolic and reproductive effects. Gynecological Endocrinology 2001;15(5):373–380.
  37. Mehrdadi P, Mohammadi RK, Alipoor E, Eshraghian M, Esteghamati A, Hosseinzadeh-Attar M. The effect of coenzyme Q10 supplementation on circulating levels of novel adipokine adipolin/CTRP12 in overweight and obese patients with type 2 diabetes. Experimental and Clinical Endocrinology and Diabetes 2017;125(03):156-62.
  38. Langleite TM, Jensen J, Norheim F, Gulseth HL, Tangen DS, Kolnes KJ, et al. Insulin sensitivity, body composition and adipose depots following 12 w combined endurance and strength training in dysglycemic and normoglycemic sedentary men. Archives of Physiology and Biochemistry 2016;122:167-79.
  39. AbouAssi H, Slentz CA, Mikus CR, Tanner CJ, Bateman LA, Willis LH, et al. The effects of aerobic, resistance, and combination training on insulin sensitivity and secretion in overweight adults from strride AT/RT: A randomized trial. Journal of Applied Physiology 2015;118:1474 82.
  40. Glynn EL, Piner LW, Huffman KM, Slentz CA, Elliot-Penry L, AbouAssi H, et al. Impact of combined resistance and aerobic training on branched-chain amino acid turnover, glycine metabolism and insulin sensitivity in overweight humans. Diabetologia 2015;58:2324-35.
  41. Malin SK, Kirwan JP, Sia CL, González F. Pancreatic β-cell dysfunction in polycystic ovary syndrome: role of hyperglycemia-induced nuclear factor-κB activation and systemic inflammation. American Journal of Physiology-Endocrinology and Metabolism 2015;308(9):E770-7.
  42. Lee-Ødegård S, Olsen T, Norheim F, Drevon CA, Birkeland KI. Potential mechanisms for how long-term physical activity may reduce insulin resistance. Metabolites 2022;12(3):208.
  43. Lee SH, Park SY, Choi CS. Insulin resistance: From mechanisms to therapeutic strategies. Diabetes and Metabolism Journal 2022;46(1):15-37.
  44. Rostamizadeh M, Elmieh A, Rahmani nia F. The effect of aerobic and resistance exercises on serum osteocalcin levels, insulin resistance and pancreas beta cell function in overweight men: A clinical trial. Journal of Rafsanjan University Medicine Science 2019;18(1):55-70.
  45. Retnakaran R, Hanley AJ, Raif N, Hirning CR, Connelly PW, Sermer M, et al. Adiponectin and beta cell dysfunction in gestational diabetes: pathophysiological implications. Diabetologia 2005;48(5):993-1001.
Daneshvar Medicine
Volume 31, Issue 2 - Serial Number 165
July and August 2023
Pages 56-67

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