Protective effect of aerobic training with Salvia officinalis consumption on endothelial function indices in postmenopausal women

Document Type : Original Article

Authors

Department of Physical Education and Sport Science, Ayatollah Amoli Branch, Islamic Azad University, Amol, Iran.

Abstract

Background and Objective: Menopause occurs with estrogens decline and impaired endothelial function and contributes to atherosclerotic risk. Adhesion molecules play an important role in the development and progression of coronary atherosclerosis. The aim of this study was comparing the effect of aerobic exercise, Salvia officinalis and their combination on serum levels of intercellular adhesion molecule (ICAM)-1, soluble vascular cellular adhesion molecule 1 (sVCAM-1) and endothelin-1 in postmenopausal women.
Materials and Methods: In this clinical trial study, 32 menopausal women (age 51.62±4.55 years, BMI 24.07±2.89 kg/square meters) were selected and were randomly divided into four groups including placebo control (C), aerobic training (AT), Salvia officinalis (So) and training-Salvia officinalis (ATSo). Training groups participated in an aerobic exercise program for eight weeks, five sessions per week (with an intensity of 40to 80% of maximum reserve heart rate, 25-45 minutes). The groups So and ATSo were provided three 100 mg So tablets daily in the morning, noon and evening. Data were tested using dependent t-test and analysis of covariance at a significance level of p<0.05.
Results: AT and So significantly decreased ICAM-1 (P=0.022 and P=0.041), sVCAM-1 (P=0.015 and P=0.018) and ET-1 (P=0.016 and P=0.023). Also, simultaneous intervention of AT and SP had a positive effect on reducing ICAM-1 (P=0.0001), sVCAM-1 (P=0.0001) and ET-1 (P=0.0001).
Conclusion: AT and So improve endothelial function in postmenopausal women by affecting serum levels of ICAM-1, sVCAM-1 and ET-1. Nevertheless, the effect of combination of exercise and supplementation was greater.

Keywords

References

  1. Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, et al. Heart disease and stroke statistics—2014 update: a report from the American Heart Association. circulation. 2014;129(3):e28-e292.
  2. Moreau KL, Hildreth KL, Meditz AL, Deane KD, Kohrt WM. Endothelial function is impaired across the stages of the menopause transition in healthy women. The Journal of Clinical Endocrinology & Metabolism. 2012;97(12):4692-700.
  3. Godo S, Shimokawa H. Endothelial functions. Arteriosclerosis, thrombosis, and vascular biology. 2017;37(9):e108-e14.
  4. Kolettis TM, Barton M, Langleben D, Matsumura Y. Endothelin in coronary artery disease and myocardial infarction. Cardiology in review. 2013;21(5):249-56.
  5. Ghosh A, Gao L, Thakur A, Siu PM, Lai CW. Role of free fatty acids in endothelial dysfunction. Journal of biomedical science. 2017;24(1):1-15.
  6. Best PJ, Lerman A. Endothelin in cardiovascular disease: from atherosclerosis to heart failure. Journal of cardiovascular pharmacology. 2000;35:S61-S3.
  7. Simbalista RL, Sauerbronn AV, Aldrighi JM, Arêas JA. Consumption of a flaxseed-rich food is not more effective than a placebo in alleviating the climacteric symptoms of postmenopausal women. The Journal of nutrition. 2010;140(2):293-7.
  8. Abdallah I, Khattab H, Sawiress F, El-Banna R. Effect of Salvia Officinalis L.(sage) herbs on osteoporotic changes in aged non-cycling female rats. Med J Cairo Univ. 2010;78(Suppl 2):1-9.
  9. Russo C, Edwards KD, Margetts G, Kleidonas S, Zaibi NS, Clapham JC, et al. Effects of Salvia officinalis L. and Chamaemelum nobile (L.) extracts on inflammatory responses in two models of human cells: Primary subcutaneous adipocytes and neuroblastoma cell line (SK-N-SH). Journal of Ethnopharmacology. 2021;268:113614.
  10. Margetts G, Kleidonas S, Zaibi NS, Zaibi MS, Edwards KD. Evidence for anti-inflammatory effects and modulation of neurotransmitter metabolism by Salvia officinalis L. BMC Complementary Medicine and Therapies. 2022;22(1):1-16.
  11. He H, Wang C, Chen X, Sun X, Wang Y, Yang J, et al. The effects of HIIT compared to MICT on endothelial function and hemodynamics in postmenopausal females. Journal of Science and Medicine in Sport. 2022;25(5):364-71.
  12. Nyberg M, Egelund J, Mandrup CM, Nielsen MB, Mogensen AS, Stallknecht B, et al. Early postmenopausal phase is associated with reduced prostacyclin-induced vasodilation that is reversed by exercise training: The Copenhagen Women Study. Hypertension. 2016;68(4):1011-20.
  13. Mayr B, Reich B, Greil R, Niebauer J. The effect of exercise training on endothelial function in postmenopausal women with breast cancer under aromatase inhibitor therapy. Cancer Medicine. 2022;11(24):4946-4953.
  14. Seals DR, Nagy EE, Moreau KL. Aerobic exercise training and vascular function with ageing in healthy men and women. The Journal of physiology. 2019;597(19):4901-14.
  15. You T, Berman DM, Ryan AS, Nicklas BJ. Effects of hypocaloric diet and exercise training on inflammation and adipocyte lipolysis in obese postmenopausal women. The Journal of Clinical Endocrinology & Metabolism. 2004;89(4):1739-46.
  16. Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, Sasani MR, Emamghoreishi M, Akbarzadeh M. The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women. Journal of family medicine and primary care. 2020;9(2):1086.
  17. Nyberg M, Seidelin K, Andersen TR, Overby NN, Hellsten Y, Bangsbo J. Biomarkers of vascular function in premenopausal and recent postmenopausal women of similar age: effect of exercise training. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2014;306(7):R510-R7.
  18. Figueroa-Vega N, Moreno-Frías C, Malacara JM. Alterations in adhesion molecules, pro-inflammatory cytokines and cell-derived microparticles contribute to intima-media thickness and symptoms in postmenopausal women. PLoS One. 2015;10(5):e0120990.
  19. Begić I, Čavka A, Mihalj M, Baćun T, Drenjančević I. Influence of short-term changes in sex hormones on serum concentrations of cellular adhesion molecules in young healthy women. Med Glas. 2012;9(1):32-6.
  20. Carneiro MA, Oliveira Júnior GNd, de Sousa JF, Orsatti CL, Murta EF, Michelin MA, et al. Effect of whole-body resistance training at different load intensities on circulating inflammatory biomarkers, body fat, muscular strength, and physical performance in postmenopausal women. Applied Physiology, Nutrition, and Metabolism. 2021;46(8):925-33.
  21. Gross MD, Bielinski SJ, Suarez-Lopez JR, Reiner AP, Bailey K, Thyagarajan B, et al. Circulating soluble intercellular adhesion molecule 1 and subclinical atherosclerosis: the Coronary Artery Risk Development in Young Adults Study. Clinical chemistry. 2012;58(2):411-20.
  22. Karim R, Stanczyk FZ, Hodis HN, Cushman M, Lobo RA, Hwang J, et al. Associations between markers of inflammation and physiological and pharmacological levels of circulating sex hormones in postmenopausal women. Menopause (New York, NY). 2010;17(4):785.
  23. Kim YH, Jeong MK, Park H, Park SK. Effects of regular taekwondo intervention on health-related physical fitness, cardiovascular disease risk factors and epicardial adipose tissue in elderly women with hypertension. International Journal of Environmental Research and Public Health. 2021;18(6):2935.
  24. Ehrlich JR, Kaluzny M, Baumann S, Lehmann R, Hohnloser SH. Biomarkers of structural remodelling and endothelial dysfunction for prediction of cardiovascular events or death in patients with atrial fibrillation. Clinical Research in Cardiology. 2011;100(11):1029-36.
  25. Wenner MM, Dow C, Greiner J, Stauffer B, Desouza C. Abstract P095: Aerobic Exercise Training Reduces Endothelin-1-mediated Vasoconstriction In Postmenopausal Women. Hypertension. 2020;76(Suppl_1):AP095-AP.
  26. Lekontseva O, Chakrabarti S, Davidge ST. Endothelin in the female vasculature: a role in aging? American Journal of Physiology-Regulatory, Integrative and Comparative Physiology. 2010;298(3):R509-R16.
  27. Novella S, Dantas AP, Segarra G, Medina P, Hermenegildo C. Vascular aging in women: is estrogen the fountain of youth? Frontiers in physiology. 2012;3:165.
  28. Ding Y-H, Young CN, Luan X, Li J, Rafols JA, Clark JC, et al. Exercise preconditioning ameliorates inflammatory injury in ischemic rats during reperfusion. Acta neuropathologica. 2005;109(3):237-46.
  29. Zhang W, Jun-Ke S, Zhang X, Qi-Meng Z, Guo-Rong H, Xiao-Na X, et al. Salvianolic acid A attenuates ischemia reperfusion induced rat brain damage by protecting the blood brain barrier through MMP-9 inhibition and anti-inflammation. Chinese journal of natural medicines. 2018;16(3):184-93.
  30. Pilsakova L, Riecanský I, Jagla F. The physiological actions of isoflavone phytoestrogens. Physiological Research. 2010;59(5):651.
  31. Sathyapalan T, Aye M, Rigby A, Thatcher N, Dargham S, Kilpatrick E, et al. Soy isoflavones improve cardiovascular disease risk markers in women during the early menopause. Nutrition, Metabolism and Cardiovascular Diseases. 2018;28(7):691-7.
  32. Squadrito F, Altavilla D, Crisafulli A, Saitta A, Cucinotta D, Morabito N, et al. Effect of genistein on endothelial function in postmenopausal women: a randomized, double-blind, controlled study. The American journal of medicine. 2003;114(6):470-6.
  33. Lebon J, Riesco E, Tessier D, Dionne IJ. Additive effects of isoflavones and exercise training on inflammatory cytokines and body composition in overweight and obese postmenopausal women: a randomized controlled trial. Menopause. 2014;21(8):869-75.
  34. Pouranfar S, azarbayjani ma, Abedi B. Interactive Effects of Resistance Training and Genistein Consumption on the levels of VCAM, ICAM and CRP in Diabetic Rats with Streptozotocin. Jorjani Biomedicine Journal. 2020;8(4):54-66.
  35. Nobuhiko A, Youngju C, Asako M, Yoko T, Jun S, Ryuichi A, et al. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012;32(10):795-9.
Daneshvar Medicine
Volume 31, Issue 2 - Serial Number 165
July and August 2023
Pages 46-55

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