Daneshvar Medicine

Daneshvar Medicine

The effect of continuous aerobic training on myelination-related parameters in the frontal cortex of rats

Document Type : Original Article

Authors
Elham Pouria Mehr 1
Amir Hossein Haghighi 1
Roya Askari 1
Majid Asadi Shekaari 2
1 Faculty of Sport Sciences, Department of Exercise Physiology, Hakim Sabzevari University, Sabzevar, Iran
2 Neuroscience Research Center, Neuropharmacology Institute, Kerman University of Medical Sciences, Kerman, Iran
10.22070/daneshmed.2022.16342.1225
Abstract
Background and Objective: Myelin-producing oligodendrocytes play an important role in supporting neuronal function in the mammalian nervous system. The formation of myelogenous oligodendrocytes from the ancestral oligodendrocyte cells requires the activity of a group of transcriptional regulators that are essential for the synthesis of myelin components. The aim of the present study was to investigate the effect of moderate intensity continuous training (MCT) on myelin-based protein (MBP) and myelin proteolipid (PLP) indices associated with myelination in the frontal cortex of rats.
Materials and Methods: 16 male Wistar rats were randomly divided into two equal groups of control and continuous training. The exercise program consisted of 24 minutes of continuous running on a treadmill for 8 weeks (5 sessions per week). At the end of the training period, the forehead cortex of rats was extracted to evaluate changes in gene expression. Data were analyzed using statistical methods of analysis of covariance and Mann-Whitney at a significant level (α≤0.05).
Results: The results showed that continuous training significantly increased the expression of MBP and PLP genes in comparison with the control group.
Conclusion: It can be said that continuous moderate intensity training can be useful in accelerating the myelination process in the cerebral cortex and can be considered as a non-invasive method in this field.
 
Keywords
Continuous training
Myelination
Myelin-based protein
Proteolipid protein
Frontal cortex
  1. Kenney WL, Wilmore J, Costill D. Physiology of sport and exercise: Human Kinetics. Champaign, IL[Google Scholar] 2015.
  2. Stadelmann C, Timmler S, Barrantes-Freer A, Simons M. Myelin in the central nervous system: structure, function, and pathology. Physiological Reviews 2019;99(3):1381-431.
  3. Quarles RH, Macklin WB, Morell P. Myelin formation, structure and biochemistry. Basic Neurochemistry: Molecular, Cellular and Medical Aspects 2006;7:51-71.
  4. Williams A. Central nervous system regeneration—where are we? QJM: An International Journal of Medicine 2014;107(5):335-9.
  5. Lau LW, Cua R, Keough MB, Haylock-Jacobs S, Yong VW. Pathophysiology of the brain extracellular matrix: a new target for remyelination. Nature Reviews Neuroscience 2013;14(10):722-9.
  6. Ahrendsen JT, Macklin W. Signaling mechanisms regulating myelination in the central nervous system. Neuroscience Bulletin 2013;29(2):199-215.
  7. Mattson MP. Energy intake and exercise as determinants of brain health and vulnerability to injury and disease. Cell Metabolism 2012;16(6):706-22.
  8. Cotman CW, Berchtold NC, Christie L-A. Exercise builds brain health: key roles of growth factor cascades and inflammation. Trends in Neurosciences 2007;30(9):464-72.
  9. Gobeske KT, Das S, Bonaguidi MA, Weiss C, Radulovic J, Disterhoft JF, et al. BMP signaling mediates effects of exercise on hippocampal neurogenesis and cognition in mice. PloS One 2009;4(10):e7506.
  10. Liu PZ, Nusslock R. Exercise-mediated neurogenesis in the hippocampus via BDNF. Frontiers in Neuroscience 2018;12:52.
  11. Trejo JL, Llorens-Martin M, Torres-Alemán I. The effects of exercise on spatial learning and anxiety-like behavior are mediated by an IGF-I-dependent mechanism related to hippocampal neurogenesis. Molecular and Cellular Neuroscience 2008;37(2):402-11.
  12. Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, et al. The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 2011;477(7362):90-4.
  13. Fuss J, Ben Abdallah NMB, Vogt MA, Touma C, Pacifici PG, Palme R, et al. Voluntary exercise induces anxiety‐like behavior in adult C57BL/6J mice correlating with hippocampal neurogenesis. Hippocampus 2010;20(3):364-76.
  14. Jensen SK, Yong VW. Activity-dependent and experience-driven myelination provide new directions for the management of multiple sclerosis. Trends in Neurosciences 2016;39(6):356-65.
  15. Tomlinson L, Leiton CV, Colognato H. Behavioral experiences as drivers of oligodendrocyte lineage dynamics and myelin plasticity. Neuropharmacology 2016;110:548-62.
  16. McKenzie IA, Ohayon D, Li H, Paes de Faria J, Emery B, Tohyama K, et al. Motor skill learning requires active central myelination. Science 2014;346(6207):318-22.
  17. Scholz J, Klein MC, Behrens TE, Johansen-Berg H. Training induces changes in white-matter architecture. Nature Neuroscience 2009;12(11):1370-1.
  18. Kiebish MA, Young DM, Lehman JJ, Han X. Chronic caloric restriction attenuates a loss of sulfatide content in PGC-1α mouse cortex: a potential lipidomic role of PGC-1α in neurodegeneration. Journal of Lipid Research 2012;53(2):273-81.
  19. Leone TC, Lehman JJ, Finck BN, Schaeffer PJ, Wende AR, Boudina S, et al. PGC-1α deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis. PLoS Biology 2005;3(4):e101.
  20. Bernardes D, Brambilla R, Bracchi‐Ricard V, Karmally S, Dellarole A, Carvalho‐Tavares J, et al. Prior regular exercise improves clinical outcome and reduces demyelination and axonal injury in experimental autoimmune encephalomyelitis. Journal of Neurochemistry 2016;136:63-73.
  21. Naghibzadeh M, Ranjbar R, TABANDEH M, Habibi A. Effect of High Intensity Exercise Preconditioning on the Prevention of Myelin damage in Hippocampus of Male C57BL/6 Mice 2019.
  22. Khalafi M, Shabkhiz F, Azali Alamdari K, Bakhtiyari A. irisin response to two types of exercise training in type 2 diabetic male rats. Journal of Arak University of Medical Sciences 2016;19(6):37-45.
  23. Kang C, Chung E, Diffee G, Ji LL. Exercise training attenuates aging-associated mitochondrial dysfunction in rat skeletal muscle: role of PGC-1α. Experimental Gerontology 2013;48(11):1343-50.
  24. Kim T-W, Sung Y-H. Regular exercise promotes memory function and enhances hippocampal neuroplasticity in experimental autoimmune encephalomyelitis mice. Neuroscience 2017;346:173-81.
  25. Alvarez-Saavedra M, De Repentigny Y, Yang D, O’Meara RW, Yan K, Hashem LE, et al. Voluntary running triggers VGF-mediated oligodendrogenesis to prolong the lifespan of Snf2h-null ataxic mice. Cell Reports 2016;17(3):862-75.
  26. Ahn JH, Choi JH, Park JH, Kim IH, Cho J-H, Lee J-C, et al. Long-term exercise improves memory deficits via restoration of myelin and microvessel damage, and enhancement of neurogenesis in the aged gerbil hippocampus after ischemic stroke. Neurorehabilitation and Neural Repair 2016;30(9):894-905.
  27. Graham LC, Grabowska WA, Chun Y, Risacher SL, Philip VM, Saykin AJ, et al. Exercise prevents obesity-induced cognitive decline and white matter damage in mice. Neurobiology of Aging 2019;80:154-72.
  28. Wang L, Psilander N, Tonkonogi M, Ding S, Sahlin K. Similar expression of oxidative genes after interval and continuous exercise. Medicine & Science in Sports & Exercise 2009;41(12):2136-44.
  29. Ng F, Wijaya L, Tang BL. SIRT1 in the brain—connections with aging-associated disorders and lifespan. Frontiers in Cellular Neuroscience 2015;9:64.
  30. Yoon H, Kleven A, Paulsen A, Kleppe L, Wu J, Ying Z, et al. Interplay between exercise and dietary fat modulates myelinogenesis in the central nervous system. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 2016;1862(4):545-55.
Daneshvar Medicine
Volume 30, Issue 5 - Serial Number 162
November and December 2022
Pages 27-36