The effect of eight weeks of high-intensity interval resistance training on serotonin 1 and 25-hydroxyvitamin D levels in overweight women with vitamin D deficiency

Document Type : Original Article


1 Department of Physical Education and Sports Sciences, Sari Branch, Islamic Azad University, Sari, Iran

2 Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran


Background and Objective: The prevalence of overweight and sedentary lifestyle is one of the major health problems in the world that are associated with oxidative stress and vitamin D deficiency. In the present study, the effect of eight weeks of high intensity interval resistance training (HIIRT) on Sirtuin 1 and 25-hydroxyvitamin D levels in overweight women with vitamin D deficiency was investigated.
Materials and Methods: This is a quasi-experimental study that was carried out on 26 overweight young inactive women with vitamin D deficiency. Subjects were selected accessibly and purposefully and then randomly assigned to the intervention and control groups (13 in each group). The main exercise consisted of three sets with 2.5 minutes rest between sets. Each set started with 6 repetitions at an intensity of 80% one repetition maximum and continued with another 20 seconds rest until exhaustion (2 or 3 subsequent repetitions). Data were analyzed by independent t-test and one-way analysis of covariance (ANCOVA) at the significant level of p<0.05.
Results: HIIRT intervention led to a significant increase in Sirtuin 1, 25-hydroxyvitamin D levels as well as superoxide dismutase activity in overweight women with vitamin D deficiency.
Conclusion: According to the results of the study, HIIRT as a non-pharmacological intervention can exert some of its supportive effects in overweight conditions with vitamin D deficiency, by improving the status of vitamin D and enhancing antioxidant defense from the Sirtuin 1/ superoxide dismutase pathway.


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