Daneshvar Medicine

Daneshvar Medicine

The effect of sprint interval training on plasma liver enzymes, liver tissue total-antioxidant-capacity and malondialdehyde in male rats

Document Type : Original Article

Authors
Mohammadhasan Ahmadi 1
Mohammad Rahmani 1
Mohsen Khalili Najafabadi 2
1 Department of exercise Sciences, Faculty of Humanities, Shahed University, Tehran, Iran
2 Neurophysiology Research Center, Shahed University, Tehran, Iran
10.22070/daneshmed.2022.15639.1164
Abstract
Objective: The aim of this study was to evaluate the effect of Sprint Interval Training (SIT) on the plasma liver enzymes, liver tissue total-antioxidant-capacity (TAC) and Malondialdehyde (MDA) levels in male rats.
Materials and Methods: In an experimental trial, 16 male rats were randomly divided into two groups: control (CO,n=8) and exercise (EX,n=8). The rats after the period of adaptation to the environment and familiarization with exercise were trained 3 sessions per week for 8 weeks. Finally, after anesthesia and direct blood sampling from the heart, serum was extracted for liver enzymes and liver tissue was removed to assess tissue TAC and MDA. Independent t-test was used to analyze the data at the alpha level of 0.05 in SPSS version 22.
Results: Statistical analysis of the data showed a significantly higher liver tissue TAC in the EX group compared to the CO group (P=0.01); but no significant intergroup difference was observed related to liver tissue MDA (P=0.24). There was no significant difference between the groups in the ALT (P=0.26) and GGT (P=0.44) level; but the AST (P=0.01) and ALP (P=0.001) level in EX group was significantly lower than CO group.
Conclusion: The results showed that SIT increases the antioxidant capacity and induces desirable changes in the liver enzymes levels and this training protocol can have a beneficial effect on the health status of the liver.
Keywords
Malondialdehyde (MDA)
Total Antioxidant Capacity (TAC)
Sprint Interval Training (SIT)
Liver enzymes
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Daneshvar Medicine
Volume 30, Issue 2 - Serial Number 159
July and August 2022
Pages 50-60