Daneshvar Medicine

Daneshvar Medicine

Effect of three methods of training, moderate-intensity aerobic exercise training, high intensity training and high-intensity interval training, on PLGF and HGF gene expression in adipose tissue in rat

Document Type : Original Article

Authors
Rokhsareh Abedi
Saeed Naghibi
Majid Gholipour Barzegar
Department of Exercise Physiology, Payame Noor University (PNU), Tehran, Iran
10.22070/daneshmed.2021.14697.1095
Abstract
Background and Objective: Exercise has many effects on human health, one of which is to help angiogenesis and prevent cardiovascular disease. The aim of this study was to investigate the effect of three training methods Moderate-Intensity Aerobic Exercise Training (MIT), High Intensity Training (HIT) and High-intensity interval training (HIIT) on the expression of HGF and PlGF genes, which are important factors involved in angiogenesis.
Materials and Methods: In this study, 32 male Wistar rats with an average weight of 300 grams were randomly divided into four groups including control, MIT, HIT and HIIT (n=8) and underwent exercise for an eight-week period. 48 hours after the last training session, samples were taken from adipose tissue of rat and the expression of HGF and PlGF genes in them was determined using Real time PCR. Statistical analysis of data was performed using SPSS and Kruskal-Wallis and Hodges-Holmes tests software.
Results: The results showed that all three training methods MIT, HIT and HIIT increase the expression of HGF and PlGF genes (P <0.05). However, there is no significant difference between the three exercise methods (P> 0.05).
Conclusion: MIT, HIT and HIIT exercises have favorable effects in increasing the expression of HGF and PlGF genes.
Keywords
Aerobic exercise
Gene expression
Placenta growth factor
Hepatocyte growth factor
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Daneshvar Medicine
Volume 29, Issue 4 - Serial Number 155
November and December 2021
Pages 55-65