Interactive effect of stevia aqueous extract and aerobic exercise on insulin resistance index and body composition of obese girls and boys during puberty

Document Type : Original Article

Authors

1 Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan.Iran.

2 Department of Sport Sciences, Faculty of Education and Psychology, University of Sistan and Baluchestan, Zahedan, Iran

Abstract

Background and Objective: Puberty is affected by obesity. The aim was to investigate the interactive effect of stevia aqueous extract consumption and aerobic exercise on insulin resistance index and body composition of obese boys and girls during puberty.
Materials and Methods: Semi-experimental research; 60 obese boys and girls aged 12-17 years who were divided into four groups: aerobic exercise, stevia, aerobic exercise + stevia, and control. Fasting glucose and insulin levels were measured and the insulin resistance index was calculated by the HOMA-IR method. Subjects practiced three sessions a week for 12 weeks with an intensity of 60 to 85% of maximum heart rate. Supplement for 12 weeks daily 12 cc of the water-soluble extract was taken 3 times after the main meal. Data were analyzed by paired t-test, one-way analysis of variance, and Bonferroni test at the significant level of p Results: The decrease in body mass index, body fat mass, insulin, and serum glucose as well as the increase in net body mass in the aerobic + stevia exercise group were significant in girls and boys (p < 0.05). HOMA-IR reduction was significant in all groups except the control group, but there was no significant difference between the changes in the two groups of aerobic exercise and control.
Conclusion: Aerobic exercise and consumption of aqueous stevia extract made favorable changes in the subjects' HOMA-IR and body composition, but some of these changes are due to the natural growth process during puberty.

Keywords

References

  1. Guercio G, Rivarola MA, Chaler E, Maceiras M, Belgorosky A. Relationship between the growth hormone/insulin-like growthfactor-I axis, insulin sensitivity, and adrenal androgens in normal prepubertal and pubertal girls. The Journal of Clinical Endocrinology and Metabolism 2003; 88(3):1389-93. doi: 10.1210/jc.2002-020979.
  2. Azeri N, Rahmati M, Fathi M. The effect of endurance exercise on blood glucose, insulin and insulin resistance in patients with type 2 diabetes: a systematic review and meta-analysis of studies conducted in Iran. Journal of Diabetes and Metabolism 2017; 17)2(:65-78.
  3. Akbarzadeh S, Barghahi A, Rahbar A, Daneshi A, Najafpour Bushehri S, Pourkhalili Kh, et al. The effects of aqueous extract of stevia plant (Stevia rebaudiana) on serum concentration of vaspin and Angiopoietin-like Protein-3 in streptozotocin induced diabetic rats. Iranian South Medical Journal 2015; 18(2): 239-249.
  4. Teymouri A, Rahmani Nia F, Mirzaee B, Tajbakhsh R. Comparison of the effects of aerobic exercise and orlistat consumption on insulin resistance and lipid profile of obese men. Quarterly Journal of Metabolism and Exercise 2017; 6(2):137-51.
  5. Davoodi Z, Ghanbarzadeh M, Shakerian S, Habibi AH. The effect of different intensities of acute aerobic activity on plasma resistin concentration and insulin resistance in men with type 2 diabetes. Journal of Fasa University of Medical Sciences 2016; 6(1):79-86.
  6. Souri R, Assad MR, Brahui Z, Rezaian, N. The effect of aerobic exercise on serum adipoline levels and insulin resistance in overweight men. Feyz Journal 2015; 19(6):495-503.
  7. Attarzadeh Hosseini SR, Mir A, Hejazi K, Mirsaidi M. The effect of eight weeks of combined training on some markers of insulin resistance in middle-aged men. Journal of Mashhad University of Medical Sciences 2015; 58(3):129-37. doi:10.22038/MJMS.2015.4521
  8. Nizam Doost Z, Saqib Joo M, Barzegar A. The effect of twelve weeks of aerobic exercise on serum levels of vaspin, fasting glucose and insulin resistance in women with type 2 diabetes. Iranian Journal of Diabetes and Metabolism 2013; 14(2):99-104.
  9. Najafi F, Goodarzi N, Zanganeh MM, Zanganeh A, Haghnazare L. Antidiabtic and hepatoprotective effects of bitter fraction of stevia rebaudiana alcoholic extract on streptozotocin-induced diabetic male mice. Journal of Rafsanjan University of Medical Sciences 2017; 16:493-504.
  10. Zanganeh MM, Goudarzi N, Zanganeh A. Evaluation of anti-diabetic and hepatic protection effects of aqueous extract of stevia leaves in streptozotocin-induced diabetic mice. Journal of Shahid Sadoughi University of Medical Sciences 2018; 26(4):319-329
  11. Mashmoli b, Abdullah Puri FS, Fazeli Fard R, Shokohi M. The role of stevia consumption in lowering blood sugar levels and complications of diabetes. Second National Conference on Medicinal Plants and Sustainable Agriculture 2015.
  12. Burt Solorzano CM, McCartney CR. Obesity and the puberta transition in girls and boys. Reproduction 2010; 140(3):399-410. doi: 10.1530/REP-10-0119.
  13. Rubin DA, McMurray RG, Harrell JS, Hackney AC, Thorpe DE, Haqq AM. The association between insulin resistance and cytokines in adolescents: the role of weight status and exercise. Metabolism: clinical and experimental 2008; 57(5):683-90. doi: 10.1016/j.metabol.2008.01.005.
  14. Goran MI, Gower BA. Longitudinal study on pubertal insulin resistance. Diabetes 2001; 50(11):2444-50. doi: 10.2337/diabetes.50.11.2444.
  15. Brandou F, Brun J-Fdr, Mercier J. Limited accuracy of surrogates of insulin resistance during puberty in obese and lean children at risk for altered glucoregulation. The Journal of Clinical Endocrinology & Metabolism 2005; 90(2):761-7. doi: 10.1210/jc.2004-0329.
  16. Shalitin S, Abrahami M, Lilos P, Phillip M. Insulin resistance and impaired glucose tolerance in obese children and adolescents referred to a tertiary-care center in Israel. International Journal of Obesity 2005; 29(6):571-8. doi: 10.1038/sj.ijo.0802919.
  17. Poretsky L, Cataldo NA, Rosenwaks Z, Giudice LC. The insulin-related ovarian regulatory system in health and disease. Endocrine Reviews 20(4):535-82. doi: 10.1210/edrv.20.4.0374.
  18. Nassis GP, Papantakou K, Skenderi K, Triandafillopoulou M, Kavouras SA, Yannakoulia M, et al. Aerobic exercise training improves insulin sensitivity without changes in body weight, body fat, adiponectin, and inflammatory markers in overweight and obese girls. Metabolism: Clinical and Experimental 2005; 54(11):1472-9. doi: 10.1016/j.metabol.2005.05.013.
  19. Brufani C, Tozzi A, Fintini D, Ciampalini P, Grossi A, Fiori R, et al. Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects. European Journal of Endocrinology 2009; 160(5):769-75. doi: 10.1530/EJE-08-0878.
  20. Ahmed ML, Ong KK, Dunger DB. Childhood obesity and the timing of puberty. Trends in endocrinology and metabolism: TEM 2009; 20(5):237-42. doi: 10.1016/j.tem.2009.02.004.
  21. Hassani A, Ebrahimi M, Ramadanpour M. Investigating three consumers on consumer survival at the level of women enabling diabetes type two. Journal of Knowledge and Education 2015;10, 4.
  22. Oyama LM, Nascimento CMOd, Carnier J, Piano Ad, Tock L, Sanches PdL, et al. The role of anorexigenic and orexigenic neuropeptides and peripheral signals on quartiles of weight loss in obese adolescents. Neuropeptides.2010; 44(6):467-74. doi: 10.1016/j.npep.2010.07.002.
  23. Abrams P, Levitt Katz LE, Moore RH, Xanthopoulos MS, Bishop-Gilyard CT, Wadden TA, et al. Threshold for improvement in insulin sensitivity with adolescent weight loss. The Journal of pediatrics 2013; 163(3):785-90. doi: 10.1016/j.jpeds.2013.04.003.
  24. Wong PC, Chia M, Tsou IY, Wansaicheong GK, Tan B, Wang JC, et al. Effects of a 12-week exercise training programme on aerobic fitness, body composition, blood lipids and C-reactive protein in adolescents with obesity. Ann Academy of Medicine, Singapore 2008; 37:286-93. PMID: 18461212.
  25. Miller CT, Fraser SF, Straznicky NE, Dixon JB, Selig SE, Levinger I. Effect of diet versus diet and exercise on weight loss and body composition in class II and III obesity: a systematic review. Journal of Diabetes and Metabolism 2013; 4(6):1-6. DOI: 10.4172/2155-6156.1000281.
  26. Hosick PA, McMurray RG, Hackney AC, Battaglini CL, Combs TP, Harrell JS. Differences in the GH-IGF-I axis in children of different weight and fitness status. Growth hormone & IGF research: Official Journal of the Growth Hormone Research Society and the International IGF Research Society 2012; 22(2):87-91. doi: 10.1016/j.ghir.2012.02.007.
  27. Leite N, Carvalho HM, Padez C, Lopes WA, Milano GE, Radominski RB. Age and menarcheal status do not influence metabolic response to aerobic training in overweight girls. Diabetology & Metabolic Syndrome 2013; 25;5(1):7. doi: 10.1186/1758-5996-5-7.
  28. Pinhas-Hamiel O, Lerner-Geva L, Copperman N, Jacobson MS. Insulin resistance and parental obesity as predictors to response to therapeutic life style change in obese children and adolescents 10-18 years old. The Journal of adolescent health: official publication of the Society for Adolescent Medicine 2008; 43(5):437-43. doi: 10.1016/j.jadohealth.2008.03.002.
  29. McLaughlin T, Abbasi F, Carantoni M, Schaaf P, Reaven G. Differences in Insulin Resistance Do Not Predict Weight Loss in Response to Hypocaloric Diets in Healthy Obese Women 1. The Journal of Clinical Endocrinology & Metabolism 1999; 84(2):578-81. doi: 10.1210/jcem.84.2.5441.
  30. Garcia JM, Iyer D, Poston WS, Marcelli M, Reeves R, Foreyt J, et al. Rise of plasma ghrelin with weight loss is not sustained during weight maintenance. Obesity 2006; 14(10):1716-23. doi: 10.1038/oby.2006.197.
Daneshvar Medicine
Volume 29, Issue 2 - Serial Number 153
July and August 2021
Pages 55-67

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