Effects of electroconvulsive therapy on manifestation of depression in alzheimer’s male rats

Document Type : Original Article

Authors

1 Department of Physiology, Faculty of Medicine, Shahed University, Tehran, Iran

2 Nurophysiology Research Center, Shahed University, Shahed University, Tehran, Iran

Abstract

Background and Objective: Depression is a common sign in Alzheimer's patients and there are many mutual mechanisms for both illnesses progression. Electroshock therapy is an effective procedure for alleviation of depression, so we used it for treatment of depression in alzheimer’s male rats.
Materials and Methods: For this purpose, 48 male Wistar rats divided in 6 groups : 1- control, 2- Depressed, 3- Alzheimer, 4- Alzheimer+shock, 5- Alzheimer+depression and 6-alzheimer+depression+shock. Dementia and depression were induced through I.C.V. injection of streptozotocin and i.p injection of reserpine respectively. Finally, the animals were subjected to memory and depression behavioral tests and their’ data were comparisoned by statistical tests.
Results: Obtained data from sucrose preference test elevated plus maze and open field showed that, electroshock therapy could yield a significant alleviation effect on mode condition of depression in Alzheimer’ rats.
Conclusion: The respectable alleviation activity of depression-like behavior due to electroshock in Alzheimer's rats which concomitant with depression, shows that this method can be used potentially in these male rats.

Keywords

References

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Daneshvar Medicine
Volume 29, Issue 2 - Serial Number 153
July and August 2021
Pages 12-20

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