The effect of acute endurance exercise after three different doses of garlic supplementation on coagulating factor VIII, fibrinogen and systolic and diastolic blood pressure in young athletic men

Document Type : Original Article

Authors

1 Department of Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran

2 Department of Sport physiology, Faculty of Educational Sciences and Psychology, University of Mohaghegh-e-Ardabili, Ardabil, Iran

Abstract

Background and Objective: The effect of acute endurance exercise after different garlic doses on coagulation factors and blood pressure are not clear. The aim of this study was  to assess the effect of an acute endurance exercise after three garlic doses and acute endurance exercise on factor VIII, fibrinogen and systolic and diastolic pressure in young athletic men.
Materials and Methods: Fifteen runners (age 27.0±7.9 years; weight 73.9±6.4kg, height 175.3±4.3 cm) voluntarily participated in this study. Subjects took garlic doses (500, 750 and 1000 mg) and placebo in separate sessions. In each session, 4 hour after the supplement or placebo, subjects performed 30 min running on treadmill, 65-85% target heart rate. Blood samples were taken before supplementation, before and immediately after exercise. The difference between doses of garlic after acute endurance exercise were analyzed with ANOVA-repeated measure and Bonferroni. The difference between garlic doses and placebo were analyzed with dependent t-test.
Results: An acute endurance exercise after three dosages significantly increased FVIII, fibrinogen and systolic blood pressure (P˂0.05). The increase of FVIII and Fibrinogen after 500 mg compared to 1000 mg of garlic and an acute endurance exercise was significantly more decreased (P˂0.05). However, an acute endurance training with 1000 mg compared to 500 mg of garlic significantly lower increased systolic blood pressure (P˂0.05). There were no significant difference in diastolic blood pressure after acute endurance exercise and garlic (P>0.05).
Conclusion: Dose of 500 mg compared to 1000 mg of garlic after an acute endurance exercise is the most effective dose for reducing FVIII and fibrinogen. After an acute endurance exercise, 1000 mg compared to 500 mg of garlic is the most effective dose for reducing systolic blood pressure.

Keywords

References

  1. Cardelle-Cobas A, Soria AC, Corzo-Martinez M, Villamiel M. A Comprehensive on Garlic Functionality. Garlic Consumption and Health 2010; 1(1):1-60.
  2. Reddy RNA, Srividya L, Swamy TP, Prasad VB. Effect of Allium sativum (Garlic) Extract on Blood Coagulation and Fibrinolysis. Advances in Pharmacology and Clinical Trials 2017; 2(1): 1-3.
  3. Soori R, Choopani C, Falahian N, Ramezankhani. Comparison of Endurance Training and Endurance Training Combined with Taking Garlic Supplement on Serum Homocysteine Levels, Tissue Plasminogen Activator in Sedentary Women. Iranian Journal of Endocrinology and Metabolism 2016; 17(6): 440-7.
  4. Saki B, Paydar SM, Amraei Z, Abarghuei AS. The Effect of Garlic Supplementation on Aerobic Performance in Non-athlete Men. Journal Iranian Journal of Nutrition Sciences and Food Technology 2015; 10(1): 115-20.
  5. Womack CJ, Lawton DJ, Redmond L, Todd MK, Hargens TA. The Effects of Acute Garlic Supplementation on the Fibrinolytic and Vasoreactive Response to Exercise. Journal of the International Society of Sports Nutrition 2015; 12(23): 1-8.
  6. Ugwu CE, Suru SM. The Functional Role of Garlic and Bioactive Components in Cardiovascular and Cerebrovascular Health: What We Do Know. Journal of Biosciences and Medicines 2016; 4(1): 28-42.
  7. Amini AM, Kordi MR, Gaini AA, Ahmadi AB, Veysi KO. Effect of Resistance Exercise on Coagulation and Fibrinolytic Factors in Inactive Aged Men. Quarterly of Ofoghe Danesh 2012; 18(1): 103-8.
  8. Kimoto R, Kambayashi I, Ishimura N, Nakamura T, and et al. Effect of Aged Garlic Extract Supplementation on the Change of Urinary 8-OHdG Content during Daily Regular and Temporary Intense Exercise. Hokkaido Journal of Medical Science 2005 10(1): 17–26
  9.  Hilberg T, Prasa D, Stürzebecher J, Gläser D, Schneider K, Gabriel HH. Blood Coagulation and Fibrinolysis after Extreme Short-term Exercise. Thrombosis Research 2003; 109(5): 271-7.
  10. Aka LO, Pilau NN, Obidike RI. The Effects of Dietary Supplementation of Allium Sativum (Garlic) on some Vital Biochemical Parameters in Male Albino Rats. Sokoto Journal of Veterinary Sciences 2010; 8(1): 26-30.
  11. Gorinstein S, Leontowicz M, Leontowicz H, Jastrzebski Z, Drzewiecki J, Namiesnik J, et al. Dose-dependent Influence of Commercial Garlic (Allium Sativum) on Rats Fed Cholesterol-Containing Diet. Journal of Agricultural and Food Chemistry 2006; 54(11): 4022-7.
  12. Morris DM, Beloni RK, Wheeler HE. Effects of Garlic Consumption on Physiological Variables and Performance during Exercise in Hypoxia. Applied Physiology, Nutrition, and Metabolism 2013; 38(4): 363–67.
  13. Bashiri J. The Effect of Regular Aerobic Exercise and Garlic Supplementation on Lipid Profile and Blood Pressure in Inactive Subjects. Zahedan Journal of Research in Medical Science 2015; 17(4): e961.1-6.
  14. Ghaediyan S, Marefati H, Nabipur F, Naghizadeh MM. The Effect of a Moderate Aerobic Exercise on the Blood Coagulation Markers in Young Non-athlete Females. Journal of Jahrom University of Medical Sciences 2012; 10(2):65-71.
  15. Bhardwaj K, Verma MK, Verma N, Bhardwaj S, and Mishra S. Effect of Long Term Supplementation of Active Garlic Allicin in Reducing Blood Pressure in Hypertensive Subjects. International Journal of Advances in Medicine 2015; 2(3): 231-234.
  16. Shahdadi H, Mansouri A, Dashtban R. A Comparative Study on the Effect of Garlic and Cumin on Blood Pressure in Ptients with Type 2 Diabetes: A Clinical Double-blind Trial. Journal of Urmia Nursing and Midwifery Faculty 2017;15(8): 605-611.
  17. Parastouei K, Ravanshad SH, Mostafavi H, and Sotoudeh Maram A. The Effect of Consumption of Garlic Pills on Blood Glucose, Plasma Lipids and Blood Pressure in Type II Diabetic Patients with Hyperlipidemia. Journal of Medicinal Plants 2005; 5 (1): 48-54.
  18. Zagheri M, Rasouli M, Tabatabaei A, Golmakani A, Mortazavi H. The Application of Complementary Medicine in Nursing with Emphasis on Therapeutic Touch. Journal of North Khorasan University of Medical Sciences 2014; 6 (1): 207-13.
  19. Khodadadi D, Siahkouhiyan M, Bolboli L. Comparison of Acute Blood Coagulation Responses to Active Exercise in Active and Passive Men. Sport physiology 2012; 4(16): 53-68.
  20. Ried K, Frank OR, Stocks NP, Fakler P, and Sullivan T. Effect of Garlic on Blood pressure: A Systematic Review and Meta-analysis. BMC Cardiovascular Disorders 2008; 8(13): 8-13.
  21.  Chan K-c, Yin M-c, Chao W-j. Effect of Diallyl Trisulfide-rich Garlic Oil on Blood Coagulation and Plasma Activity of Anticoagulation Factors in Rats. Food and Chemical Toxicology 2007; 45(3): 502-7.
  22. Ohaeri O, Adoga G. Anticoagulant Modulation of Blood Cells and Platelet Reactivity by Garlic Oil in Experimental Diabetes Mellitus. Bioscience Reports 2006; 26(1): 1-6.
  23. Ried K, Travica N, Sali A. The Effect of Aged Garlic Extract on Blood Pressure and other Cardiovascular Risk Factors in Uncontrolled Hypertensives: the AGE at Heart Trial. Integrated Blood Pressure Control 2016; 9(1): 9-21.
  24. Kyle J D, Brian LS, Jared J, Liz C, Christopher AD. Regular Aerobic Exercise Enhances Endothelium tPA Release in Adults with HIV-1. Arteriosclerosis, Thrombosis, and Vascular Biology 2014; 34(1): A388.
  25. Morihara N, Ushijima M, Kashimoto N, Sumioka I, Nishihama T, Hayama M, et al. Aged Garlic Extract Ameliorates Physical Fatigue. Biological and Pharmaceutical Bulletin 2006; 29(5): 962-6.
  26. Gebreyohannes G, Gebreyohannes M. Medicinal Values of Garlic: A Review. International Journal of Medicine and Medical Sciences 2013; 5(9): 401-408.
  27. Williams MJ, Sutherland WH, McCormick MP, Yeoman DJ, and de Jong SA. Aged Garlic Extract Improves Endothelial Function in Men with Coronary Artery Disease. Phytotherapy Research 2005; 19(4): 314-9.
  28. Naderi M, Foroutan L, and Kouh Khil A. The Application of Traditional Medl Methods in the Treatment of Diabetes. Journal of Diabetes Nursing 2013; 1 (1): 53-9.
  29. Kumar R, Chhatwal S, Arora S, Sharma S, Singh J, and Singh N. Anti Hyperglycemic, Anti-hyperlipidemic and Anti-inflammatory and Adenosine Deaminase-lowering Effects of Garlic in Patients with Type 2 Diabetes Mellitus with Obesity. Diabetes, Metabolic Syndrome and Obesity 2013; 6(1): 49-56.
  30. Ried k, and Fakler P. Potential of Garlic (Allium Sativum) in Lowering High Blood Pressure: Mechanisms of Action and Clinical Relevance. Integrated Blood Pressure Control 2014; 7: 71-82.
Daneshvar Medicine
Volume 28, Issue 5 - Serial Number 150
November and December 2020
Pages 63-74

Files

Share

How to cite

Statistics