Daneshvar Medicine

Daneshvar Medicine

Comparison of the effect of aerobic and resistance training on glucagon-like peptide-1 and insulin resistance in obese women with type 2 diabetes

Document Type : Original Article

Authors
Saeideh Tabibirad
Hosein Aabednatanzi
Hojatallah Nik bakht
Farshad Ghazalian
Mandana Gholami
Department of Physical Education and Sport Sciences, Faculty of Literature, Humanities and Social Sciences, Science and Research Branch, Islamic Azad University, Tehran, Iran
10.22070/daneshmed.2020.2977
Abstract
Objective: The purpose of this study was to compare the effects of aerobic and endurance training on GLP-1 and insulin resistance in obese women with type 2 diabetes.
Materials and Methods: Thirty diabetic women aged 35-50 years, members of Saveh Diabetes Association, voluntarily participated in the present study and randomly divided into three groups of control (n=10), aerobic exercise (n=10) and resistance training (n=10). 24 hours before the start of the exercise protocol, individual characteristics and blood sampling were measured in the pre-test. Then the aerobic and resistance training groups performed their own training program for eight weeks (3 sessions per week and each session lasted 45-60 minutes). After eight weeks and 24 hours after the last training session individual data and blood samples were measured and analyzed using one-way ANOVA at p<0.05.
Results: The present study showed no significant difference between the effects of the two training methods on insulin resistance (P=0.922), but there was a significant difference between the effects of the two training methods on GLP-1 values (P=0.001).
Conclusion: Aerobic and resistance training can decrease appetite and weight control in obese women with type 2 diabetes by increasing     GLP-1. Aerobic training also seems to be more effective than resistance training.
Keywords
Aerobic training
Resistance training
Obese women
Type 2 diabetes
GLP-1
  1. Dostdar Y, Mohajeri D, Rezaii A. The effect of grape seed extract on cardiac cell apoptosis in diabetic rats Posted by streptozotocin. Medical Sciences Journal of Islamic Azad University,Tehran Medical Branch 2011;21(3)168-174.
  2. Sori R, Ranjbar hasani SH, Vahabi K, SHabkhiz F.The effect of periodic aerobic exercise on serum RBP4 and insulin resistance index in type 2 diabetic patients. Iranian Journal of Diabetes and Metabolism 2011;10(4):388-397.
  3. Brrera JG, Sandoval DA, D’Alessio DA, Seeley RJ. GLP-1 and energy balance: an integrated model of short-term and long-term control. Nature Reviews Endocrinology 2011; 7: 507-516.
  4. Creutzfeldt W. The incretin concept today. Diabetologia 1979;16:75–85.
  5. Abbasi deloii A, Eshaghi R, Ahmadi M, Kohan por M. The effect of a resistance training course on serum levels of glucagon-like peptide, dipeptidyl peptidase-4 and insulin resistance in obese men. Physiology of Exercise and Physical Activity 2017;10(1):21-29.
  6. Lamers D, Famulla S, Wronkowitz N, Hartwig S, Lehr S, Ouwens DM. Dipeptidyl peptidase 4 is a novel adipokine potentially linking obesity to themetabolic syndrome. Diabetes 2011; 60(7):1917-25
  7. Howe SM, Hand TM, Manore MM. Exercise-trained men and women: role of exercise and diet on appetite and energy intake. Nutrients 2014; 6(11):4935-4960.
  8. Martins C, Kulseng B, King NA, Holst JJ and Blundell JE. The effects of exercise-induced weight loss on appetite- related peptides and motivation to eat. Journal of Clinical Endocrinology & Metabolism 2010;95(4):1609-1616.
  9. Yosefipoor P, Tadibi V, Behpoor N, Parno A, Delbari M, Rashidi S. ffects of aerobic exercise on glucose control and cardiovascular risk factor in type 2 diabetes patients. Medical Journal of Mashhad University of Medical Sciences 2014; 57(9):976-984.
  10. Singh B, Arora S, Goswami B, Mallika V. Metabolic syndrome: A review of emerging markers and management. Diabetes & Metabolic Syndrome: Clinical Research & Reviews 2009;3(4):240-254.
  11. Ranganath LR. Incretins: pathophysiological and thera peutic implications of glucose-dependent insulinotropic polypeptide and glucagon-like peptide-1. Journal of Clinical Pathology 2008; 61(4):401-9.
  12. Ellingsgaard H, Hauselmann I, Schuler B, Habib AM, Baggio LL, Meier DT, et al. Interleukin-6 enhances insulin secretion by increasing glucagon-like peptide-1 secretion from L cells and alpha cells. Nature Medicine 2011;17(11):1481-9.
  13. Abolfathi F, Shabani M, Alizadeh A. The effect of acute aerobic exercise on changes in serum GLP-1 levels in type 2 diabetic women. Iranian Journal of Endocrinology & Metabolism 2016;18(6):432-436.
  14. Ueda SY, Yoshikawa T, Katsura Y, Usui T, Nakao H, Fujimoto S. Changes in gut hormone levels and negative energy balance during aerobic exercise in obese young males. Journal of Endocrinology 2009; 201(1):151-9.
  15. Farzanegi P. The effect of aerobic training and Arbutin on GLP1 and GLP1R in diabeties Rats. Indian Journal of Fundamental and Applied Life Sciences 2014;4(4): 356-362.
  16. Lee SS, Yoo JH, So YS. Effect of the low- versus high-intensity exercise training on endoplasmic reticulum stress and GLP-1 in adolescents with type 2 diabetes mellitus. Joural of Physical Therapy Science 2015; 27(10):3063-8.
  17. Chanoine JP, Mackelvie KJ, Barr SI, Wong AC, Meneilly GS and Elahi DH. GLP-1 and appetite responses to a meal in lean and overweight adolescents following exercise. Obesity 2008; 16(1):202-4.
  18. Saghi F, Hakkak dokht E, Moazzami M. The compersion of aerobic training and resistance training on plasma omentin and insulin resistance and lipid profile in obese postmenopausal women Metabolism and Exercise a Biannual Journal 2017;7(2):169-182.
  19. Esmaeili M, Bijhaf N, Ghahramani moghadam M, The effect of combined (aerobic-resistance) training on aerobic fitness, muscle strength, blood glucose, insulin resistance and serum beta-endorphin levels in type 2 diabetic women. Iranian Journal of Obstetrics, Gynecology and Infertility 2018;21(6):34-46.
  20. Sunghwan S, In-Kyong J, Kim M, Yeon S, Sue S, Jae HK. Effects of Resistance Training and Aerobic Exercise on Insulin Sensitivity in Overweight Korean Adolescents: A Controlled Randomized Trial. Diabetes & Metabolism Journal 2011; 35(4):418–426.
  21. Aminot-gilchrist DV, Anderson HD. Insulin resistance associated cardiovascular disease: potential benefits of CLA. American Journal Clinic Nutration 2004; 79(6):1159-1163.
Daneshvar Medicine
Volume 28, Issue 4 - Serial Number 149
September and October 2020
Pages 46-56