Background and Objective: Lead can cause liver damage in which
oxidative stress is involved. Exercise and use of anti-oxidative substances such as anti-oxidative curcumin may stop < /span>
the production of free radicals. The purpose of the present study was
to investigate the protective effect of endurance
training and curcumin against lead toxic effect on hepatic tissue in male rats. Materials and
Methods: In this experimental study, 60
male Wistar rats were randomly
divided into 6 groups, control , sham, lead, exercise + lead, curcumin+lead and exercise+lead+curcumin (n=10 in each group). The exercise training
consisted of 25-64 min of running on an ungraded
treadmill at a speed of
15-22 m/min for 8 weeks. Curcumin (30 mg/kg) and lead (20 mg/kg of lead acetate) were administered for 8 weeks, 3 days/week, intraperitoneally. Serum ALT, AST and ALP were measured by colorimetric method. Results: The results showed that 8 weeks of lead
exposure causes a significant increase of AST and ALT
in the lead group < /font>
as compared to control group < /font> (p =0.002,
p = 0.007, respectively). Endurance training and curcumin consumption significantly decreased AST and
ALT(p =0.041 and p =0.009, respectively). After endurance training and curcumin consumption, ALP non-significantly decreased
(p =0.692). Conclusion: Regular exercise and curcumin supplement may
inhibit liver damage induced
by lead.
farzanegi, P., habibian, M., & salehi, M. (2012). Interactive effect of endurance training and curcumin supplementation on some indices of liver damage in rats exposed to heavy metal lead. Daneshvar Medicine, 20(4), 63-70.
MLA
parvin farzanegi; masoumeh habibian; mohammadreza salehi. "Interactive effect of endurance training and curcumin supplementation on some indices of liver damage in rats exposed to heavy metal lead". Daneshvar Medicine, 20, 4, 2012, 63-70.
HARVARD
farzanegi, P., habibian, M., salehi, M. (2012). 'Interactive effect of endurance training and curcumin supplementation on some indices of liver damage in rats exposed to heavy metal lead', Daneshvar Medicine, 20(4), pp. 63-70.
VANCOUVER
farzanegi, P., habibian, M., salehi, M. Interactive effect of endurance training and curcumin supplementation on some indices of liver damage in rats exposed to heavy metal lead. Daneshvar Medicine, 2012; 20(4): 63-70.
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