Effects of 8-week combined training (aerobic and resistance) on serum levels of irisin and leptin in overweight men

Document Type : Original Article

Authors

1 Faculty of Humanities, Islamic Azad University Rasht Branch, Rasht, Iran

2 Faculty of Physical Education and Sports Sciences, University of Guilan, Rasht, Iran

Abstract

Background and Objective: Irisin is released from the Fndc5 membrane protein through physical activity and affects on thermogenics metabolism through browning of white fat. The purpose of this study was to investigate the effects of eight weeks of combination aerobic and resistance training on irisin and leptin levels in overweight men.
Materials and Methods: The present quasi-experimental study was performed with pre- and post-test design. 22 overweight men were selected and randomly divided into training groups (11 people: Age = 31.54 ± 2.62, BMI = 28.33 ± 1.04)  and control groups control (11 people: Age = 30.54 ± 1.63, BMI = 28.76 ± 1.05) They participated in a combined training program (Aerobic with an intensity of 65-85% maximum heart rate and resistance with 50% 1RM) for 8 weeks and 4 sessions per week. Blood samples were taken 24 hours before and 48 hours after the end of the research project to measure serum iris and leptin levels. Data were analyzed using the t-test and Pearson correlation coefficient.
Results: The results of the present study showed that the levels of irisin did not decrease significantly after 8 weeks of training (P=0.14). Leptin also did not decrease significantly after 8 weeks of training (P>0.05). Pearson correlation coefficient did not show a significant relationship between irisin and leptin (P>0،05).
Conclusion: Based on research results, irisin levels did not decrease significantly after 8 weeks of training (P=0.14). The lack of a significant increase in irisin and a decrease in leptin showed that combined exercise can be useful for weight loss and fitness in overweight people. 

Keywords

References

  1. Lu Y, Li H, Shen S-W, Shen ZH, Xu M, Yang C-J. Swimming exercise increases serum irisin level and reduces body fat mass in high-fat-diet fed Wistar rats. Lipids in Health and Disease Journal 2016; 15(1):93-106.
  2. Hecksteden A, Wegmann M, Steffen A, Kraushaar J, Morsch A, Ruppenthal S, et al. Irisin and exercise training in humans–results from a randomized controlled training trial. BioMed Medicine Journal 2013; 11(1): 235-249.
  3. Pilch W, Szyguła Z, Klimek AT, Pałka T, Cisoń T. Changes in the lipid profile of blood serumin women taking sauna baths of various duration. International Journal of Occupational Medicine and Environmental Health 2010; 23(2): 167-74.
  4. Cui H, López M, Rahmouni K. The cellular and molecular bases of leptin and ghrelin resistance in obesity. Nature Reviews Endocrinology 2017; 13(6): 338-351.
  5. Boström P, Wu J, Jedrychowski MP, Korde A, Ye L, Lo JC, et al. A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis. A Nature Research Journal 2012; 481 (7382): 463 - 68.
  6. Bluher S, Panagiotou G, Petroff D, Markert J, Wagner A, Klemm T. Effects of a 1-year exercise and lifestyle intervention on irisin، adipokines، and inflammatory markers in obese children. Obesity 2014; 22(7):1701–708.
  7. Yu N, Ruan Y, Sun J. Systematic Review and Meta-Analysis of Randomized, Controlled Trials on the Effect of Exercise on Serum Leptin and Adiponectin in Overweight and Obese Individuals. Hormone and Metabolic Research 2017; 49(03): 164-73.
  8. Pekkala S, Wiklund PK, Hulmi J, Ahtiainen JP, Horttanainen M, Pöllänen E, et al. Are skeletal muscle FNDC5 gene expression and irisin release regulated by exercise and related to health? The Journal of Physiology 2014; 591(21):5393-400.
  9. Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath T L, et al. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature Macmillan Magazines Ltd 2011; 411(20):480–484.
  10. Dhilon H, Kalra SP, Prima V, Zolotukhin PJ, Scarpese PJ, Moldawer LL, et al. Central leptin gene therapy suppresses body weight gain، adiposity and serum insulin without affecting food consumption in normal rat: a long -term study. Regulatory Peptides Journal 2001; 99 (3): 69-77.
  11. EL-Haschimi K, Pierroz DD, Hileman SM, Bjorbaek C, Flier JS. Two defect contribute to hypothalamic leptin resistance in mice with diet induced obesity. Journal of Clinical Investigation 2010; 105(12):1827-32.
  12. Kurdiova T, Balaz M, Vician D, Maderova M, Vlcek L, Valkovic et al. Are skeletal muscle & adipose tissue Fndc5 gene expression and irisin release affected by obesity diabetes and exercise? In vivo & in vitro studies. The Journal of Physiology 2014; 592(5):1091-107.
  13. Huh JY, Panagiotou G, Mougios V, Brinkoetter M, Vamvini MT, Schneider B, et al. FNDC5 and irisin in humans: I, Predictors of circulating concentrations in serum and plasma and II, mRNA expression and circulating concentrations in response to weight loss and exercise Metabolism. Metabolism Clinical and Experimental Journal 2016; 61(12):1725-738.
  14. Fatouros I, G. Is Irisin the new player in exercise-induced adaptations or not? A 2017 update. Clinical Chemistry and Laboratory Medicine 2018; 56(4):525-548.
  15. Gholaman M. Effect of Eight Weeks, Endurance Training along with Fenugreek Ingestion on Lipid Profile, Body Composition, Insulin Resistance and VO2max in Obese Women’s with Type2 Diabetes. Journal of Medicinal Plants 2018; 1(65):83-92.
  16. Guilford BL, Ryals JM, Lezi E, Swerdlow RH, Wright DE. Dorsal Root Ganglia Mitochondrial Biochemical Changes in Non-diabetic and Streptozotocin-Induced Diabetic Mice Fed with a Standard or High-Fat Diet. Journal of Neurology and Neuroscience 2017;8(2):180.
  17. Nygaard H, Slettaløkken G, Vegge G, Hollan I, Whist J E, Strand T, et al. Irisin in blood increases transiently after single sessions of intense endurance exercise and heavy strength training. Public Library of Science Journal 2015;10(3):1367-71.
  18. Hoshino D, Yoshida Y, Kitaoka Y, Hatta H, Bonen A. Highintensity interval training increases intrinsic rates of mitochondrial fatty acid oxidation in rat red and white skeletal muscle. Applied Physiology Nutrition and Metabolism 2013; 38(3):326-33.
  19. Bartlett JD, Hwa Joo C, Jeong TS, Louhelainen J, Cochran AJ, Gibala MJ, et al. Matched work high-intensity interval and continuous running induce similar increases in PGC-1α Mrna, AMPK, p38 and p53 phosphorylation in human skeletal muscle. Journal of Applied Physiology 2012;112(7):1135-43.
  20. Tsuchiya Y, Mizuno S, Morii I, Goto K. Irisin Response To Down-hill Running Exercise In Humans. Medicine and Science in Sports and Exercise 2018; 48(5):1029-35.
  21. Souri R, Asad M, Khosravi M, Abbassian S. Comparison of Regular Aerobic Exercise Intensity on Changes in Serum Levels of Irisin in Sedentary Obese Men. Iranian Journal of Endocrinology and Metabolism 2016; 18(4):270-78.
  22. Dun SL, Lyu RM, Chen YH, Chang JK, Luo JJ, Dun NJ. Irisin- immunoreactivity in neural and non-neural cells of the rodent. Neuroscience 2013; 240(14):155–62.
  23. Pardeus. Leptin the next big thing big mother. Rucher Magazine 2000; 91 (7):10-12.
  24. Motamedy P, Nikroo H, Hejazi K. The effects of eight - weeks aerobic training on serum leptin levels, anthropometric indices and VO2max in sedentary Obese men. Iranian Journal of Ergonomics 2017; 5(1):36–42.
  25. Sanchis-Gomar F, Alis R, Pareja-Galeano H, Romagnoli M, Perez-Quilis C. Inconsistency in circulating irisin levels: what is really happening? Hormone and Metabolic Research 2014; 46(8):591-6.
  26. Noland R. Effects of intense training on plasma Leptin in male and femal swimmers. Medicine and Science in Sport and Exercise 2001; 33(2):227-31.
Daneshvar Medicine
Volume 28, Issue 4 - Serial Number 149
September and October 2020
Pages 10-22

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