Evaluation of serum and sputum level of IL-21 in Sardasht chemical victims and its relationship with long-term pulmonary complications (27 years after sulfur mustard exposure)

Authors

Abstract

Background and Objectives: Pulmonary complications are one of the most important long-term sulfur mustard (SM) exposure that chemical victims are suffering for years. IL-21 is one of the important cytokines contributing in chronic pulmonary inflammatory diseases. In this study, the serum and sputum levels of IL-21 and their correlations with pulmonary complications was evaluated 27 years after sulfur mustard exposure.
 
Materials and Methods: Final sample size was 475 (350 men and 125 women) SM exposed and 150 (100 men and 50 women from Rabat) unexposed controls. The age span of volunteers was 27-67 years.
 
Results: There was no significant different between exposed and control groups in serum and sputum levels of IL-21, but the serum level of IL-21 showed a significant correlation with spirometry parameter (FEV1/FVC) in SM exposed group was observed.
 
Conclusion: The affected serum and sputum levels of IL-21 by sulfur mustard exposure were not variable, but there was a significant negative correlation between serum level of IL-21and FEV1/FVC in SM exposed group.

Keywords

References

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Daneshvar Medicine
Volume 25, Issue 2 - Serial Number 129
July and August 2017
Pages 1-8

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