Background and Objective: Some of medicinal plants have been used for pain
reliving in Iarnian ancient medicine. Astragalus
gummifer (AG) is one of them and its gum (tragacanth gum) were used
for several health purposes. The present study was conducted to evaluate the
analgesic effects of this gum in mice. Materials and Methods: In this study, the analgesic
effect of tragacanth gum was determined using
hot-plate and writhing tests. Mice were injected with tragacanth gum
at doses of 125, 250 or 500 µg/kg i.p. as treatment
groups. Morphine at doses of 2, 4 or 8 µg/kg i.p., and diclofenac at doses of 10,
20 or 30 µg/kg i.p. were used as control groups. Results: In writhing
test, gum tragacanth at different doses (125, 250, and 500 µg/kg ) significantly reduced the
number of writhings in mice as compared to control group (p < 0.05). In hot-plate
test, maximum possible effect of tragacanth gum significantly increased only
after 15 minutes but not in other time periods. In two models of pain assesment,
both morphine sulfate and diclofenac sodium had also pain relieving potential. Coclusion: The present study indicated that tragacanth gum elicits prominent
analgesic effects in an experimental model of acute and chronic pain.
Additionally, data obtained in this study indicated the presence of some
constituents with pain releiving properties that confirms the traditional use
of the gum for pain relieving purposes.
Keihani, L., Rezvani, M. E., & Dashti- Rahmatabadi, M. H. (2012). A comparison between the analgesic effect of tragacanth gum, diclofenac and morphine in mice using writhing and hot-plate analgesic tests. Daneshvar Medicine, 20(4), 25-34.
MLA
Leila Keihani; Mohammad Ebrahim Rezvani; Mohammad Hossain Dashti- Rahmatabadi. "A comparison between the analgesic effect of tragacanth gum, diclofenac and morphine in mice using writhing and hot-plate analgesic tests". Daneshvar Medicine, 20, 4, 2012, 25-34.
HARVARD
Keihani, L., Rezvani, M. E., Dashti- Rahmatabadi, M. H. (2012). 'A comparison between the analgesic effect of tragacanth gum, diclofenac and morphine in mice using writhing and hot-plate analgesic tests', Daneshvar Medicine, 20(4), pp. 25-34.
VANCOUVER
Keihani, L., Rezvani, M. E., Dashti- Rahmatabadi, M. H. A comparison between the analgesic effect of tragacanth gum, diclofenac and morphine in mice using writhing and hot-plate analgesic tests. Daneshvar Medicine, 2012; 20(4): 25-34.
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