Background and Objective: Considering the higher incidence of atherosclerosis and cardiovascular disorders in diabetes mellitus, this study was conducted to evaluate the beneficial effect of oral 6-week administration of Cynara scolymus L. (CS) on contractile reactivity of isolated thoracic aorta. Materials and Methods: Wistar rats were divided into control, CS-treated control, diabetic, and CS-treated diabetic groups. For induction of diabetes, streptozotcin (STZ) was intraperitoneally administered (60 mg/Kg). Meanwhile, CS-treated groups received CS mixed with standard pelleted food at a weight ratio of 6.25% for 6 weeks. After 6 weeks, contractile reactivity of thoracic aortic rings to KCl and noradrenaline was determined using isolated tissue setup. Results: Although CS-treated diabetic group did not show a significant reduction in KCl-induced contractile respone as compared to diabetic groupa, but NA-induced response was significantly lower in treated-diabetic group (P < 0.05) as compared to diabetic group. Meanwhile, there was no significant difference between control and CS-treated control groups regarding contractile reactivity. Conclusion: Oral administration of CS for 6 weeks could improve hyperglycemia and also attenuate the contractile responsiveness of the vascular system and this may prevent the development of hypertension in diabetic rats.
narenjkar, J., roghani, M., sedaghat, R., & tahami, M. (2010). The effect of oral feeding of Cynara scolymus L. on thoracic aorta contractile response in diabetic rats. Daneshvar Medicine, 18(2), 43-52.
MLA
jamshid narenjkar; mehrdad roghani; reza sedaghat; mohamad tahami. "The effect of oral feeding of Cynara scolymus L. on thoracic aorta contractile response in diabetic rats". Daneshvar Medicine, 18, 2, 2010, 43-52.
HARVARD
narenjkar, J., roghani, M., sedaghat, R., tahami, M. (2010). 'The effect of oral feeding of Cynara scolymus L. on thoracic aorta contractile response in diabetic rats', Daneshvar Medicine, 18(2), pp. 43-52.
VANCOUVER
narenjkar, J., roghani, M., sedaghat, R., tahami, M. The effect of oral feeding of Cynara scolymus L. on thoracic aorta contractile response in diabetic rats. Daneshvar Medicine, 2010; 18(2): 43-52.
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