Shahed UniversityDaneshvar Medicine2716-972321620200926The effect of stretching exercise on physical health composite in patients with multiple sclerosisThe effect of stretching exercise on physical health composite in patients with multiple sclerosis161601FAJournal Article20200926Background and Objective: Multiple sclerosis is the most common neurological diseases that cause disability in the nervous system which reduces quality of life. Stretching exercise is a low-cost and non-invasive method that can be used to improve physical health composite. The aim of this study was to determine the effect of stretching exercises on the physical health composite for patients with multiple sclerosis (MS).
Materials and Methods: In this quasi-experimental study, 90 patients with MS were recruited from Tehran MS association and Sina hospital research center. Subjects were divided into two groups of experimental and control. MSQOL-54 scale was used to evaluate the physical health for both groups at first. Then, the correct way of exercises is taught to patients. Experimental groups did stretching exercise for 12 weeks, three times every week. Subjects in control group did not have any intervention. Quality of life was again measured in both groups after 12 weeks. Collecting method was based on personal information and MSQOL-54. The data were analyzed by SPSS software version 18.
Results: There were no significant differences regarding physical health at baseline in the two groups (p=0.82). There was a significant result that shows physical health score in experimental group increases as compared to control group (p < 0.001).
Conclusion: According to the present results, stretching exercise raises quality of life of multiple sclerosis patients. Therefore, this method is safe, simple, non-invasive and low-cost that is recommended.Background and Objective: Multiple sclerosis is the most common neurological diseases that cause disability in the nervous system which reduces quality of life. Stretching exercise is a low-cost and non-invasive method that can be used to improve physical health composite. The aim of this study was to determine the effect of stretching exercises on the physical health composite for patients with multiple sclerosis (MS).
Materials and Methods: In this quasi-experimental study, 90 patients with MS were recruited from Tehran MS association and Sina hospital research center. Subjects were divided into two groups of experimental and control. MSQOL-54 scale was used to evaluate the physical health for both groups at first. Then, the correct way of exercises is taught to patients. Experimental groups did stretching exercise for 12 weeks, three times every week. Subjects in control group did not have any intervention. Quality of life was again measured in both groups after 12 weeks. Collecting method was based on personal information and MSQOL-54. The data were analyzed by SPSS software version 18.
Results: There were no significant differences regarding physical health at baseline in the two groups (p=0.82). There was a significant result that shows physical health score in experimental group increases as compared to control group (p < 0.001).
Conclusion: According to the present results, stretching exercise raises quality of life of multiple sclerosis patients. Therefore, this method is safe, simple, non-invasive and low-cost that is recommended.https://daneshvarmed.shahed.ac.ir/article_1601_c559da2ba967eb820766939a658022c8.pdfShahed UniversityDaneshvar Medicine2716-972321620200926Protective effect of biochanin A on the hepatic and renal function of diabetic ratsProtective effect of biochanin A on the hepatic and renal function of diabetic rats7161602FAJournal Article20200926Background and Objective: Biochanin A, a bioflavonoid in red clover and soybeans, is well-known as an anti-diabetic and anti-lipidemic flavonoid. The aim of this investigation was to study the renal and hepatic effects of biochanin A in streptozocin-induced diabetic rats.
Materials and Methods: Diabetes was induced in Wistar rats by administration of streptozocin (35 mg/kg of body weight) intraperitoneally. Diabetic rats were treated with 10 and 15 mg/kg (body weight) of biochanin A in 5% DMSO for 30 days. Body weight and biochemical parameters including fasting blood glucose level (FBG), glycosylated hemoglobin (HbA1c), lipid profile, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea and creatinine were assessed.
Results: The data showed normalization and restoration of biochemical parameters such as body weight (BW), FBG, HbA1c and lipid profile in STZ-diabetic rats after oral administration of biochanin A. The results showed significant increases in hepatic enzymes, urea and creatinine in STZ-diabetic rats and oral administration of biochanin A significantly decreased AST, ALT, ALP, urea and creatinine. The data of this investigation also indicate that protective effect of biochanin A on hepatic and renal tissues is greater at a dose of 10 mg/kg as compared to a dose of 15 mg/kg.
Conclusion: Oral administration of biochanin A due to its anti-diabetic, anti-lipidemic effect has a protective effect on hepatic and renal function. The data of this investigation indicate that biochanin A is not toxic.Background and Objective: Biochanin A, a bioflavonoid in red clover and soybeans, is well-known as an anti-diabetic and anti-lipidemic flavonoid. The aim of this investigation was to study the renal and hepatic effects of biochanin A in streptozocin-induced diabetic rats.
Materials and Methods: Diabetes was induced in Wistar rats by administration of streptozocin (35 mg/kg of body weight) intraperitoneally. Diabetic rats were treated with 10 and 15 mg/kg (body weight) of biochanin A in 5% DMSO for 30 days. Body weight and biochemical parameters including fasting blood glucose level (FBG), glycosylated hemoglobin (HbA1c), lipid profile, aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), urea and creatinine were assessed.
Results: The data showed normalization and restoration of biochemical parameters such as body weight (BW), FBG, HbA1c and lipid profile in STZ-diabetic rats after oral administration of biochanin A. The results showed significant increases in hepatic enzymes, urea and creatinine in STZ-diabetic rats and oral administration of biochanin A significantly decreased AST, ALT, ALP, urea and creatinine. The data of this investigation also indicate that protective effect of biochanin A on hepatic and renal tissues is greater at a dose of 10 mg/kg as compared to a dose of 15 mg/kg.
Conclusion: Oral administration of biochanin A due to its anti-diabetic, anti-lipidemic effect has a protective effect on hepatic and renal function. The data of this investigation indicate that biochanin A is not toxic.https://daneshvarmed.shahed.ac.ir/article_1602_1bc0249a6412ef49b07fe6f62e6dc8de.pdfShahed UniversityDaneshvar Medicine2716-972321620200926Analysis of hospitalization length for cerebrovascular accident patients in Sabzevar Vaseyee hospital using count regression modelsAnalysis of hospitalization length for cerebrovascular accident patients in Sabzevar Vaseyee hospital using count regression models17241603FAJournal Article20200926Background and Objective: The hospitalization length of admitted patients is very important for the management of hospitals. Due to the significance of this subject and few similar researches in this area, the current study has been done to model the number of days of stay for cerebrovascular accident (CVA) patients in Sabzevar Vaseyee hospital and to determine its relation with independent variables.
Materials and Methods: The current study was designed on modeling the number of stay days for CVA patients in Sabzevar Vaseyee hospital in 2012. By using random sampling, 179 persons were selected and the value of the length of stay as the response variable and the value of gender, age and residence location of these patients as the independent variables were considered and count regression models and SAS9.2 software were used to analyze the gathered data.
Results: The obtained results of this study showed that the average of stay length for CVA patients is 5.13±2.67 (mean±standard deviation) in Vaseyee hospital. Also, the finding of the regression models used in this study presented that the length of stay of patients increases one day on the average for a one-year increase in patient’s age. Moreover, the relations between gender and residence location variables with length of stay variable were obtained.
Conclusion: Due to the significance of the stay length of patients and because of its different values in different units and hospitals, the application of these advanced statistical models is also proposed in other hospitals and cities.Background and Objective: The hospitalization length of admitted patients is very important for the management of hospitals. Due to the significance of this subject and few similar researches in this area, the current study has been done to model the number of days of stay for cerebrovascular accident (CVA) patients in Sabzevar Vaseyee hospital and to determine its relation with independent variables.
Materials and Methods: The current study was designed on modeling the number of stay days for CVA patients in Sabzevar Vaseyee hospital in 2012. By using random sampling, 179 persons were selected and the value of the length of stay as the response variable and the value of gender, age and residence location of these patients as the independent variables were considered and count regression models and SAS9.2 software were used to analyze the gathered data.
Results: The obtained results of this study showed that the average of stay length for CVA patients is 5.13±2.67 (mean±standard deviation) in Vaseyee hospital. Also, the finding of the regression models used in this study presented that the length of stay of patients increases one day on the average for a one-year increase in patient’s age. Moreover, the relations between gender and residence location variables with length of stay variable were obtained.
Conclusion: Due to the significance of the stay length of patients and because of its different values in different units and hospitals, the application of these advanced statistical models is also proposed in other hospitals and cities.https://daneshvarmed.shahed.ac.ir/article_1603_f3173935ed8ac4bf073c1bcd63171f8a.pdfShahed UniversityDaneshvar Medicine2716-972321620200926Evaluation of care dependency among elderly residents of nursing homes in Ahvaz city in 2012Evaluation of care dependency among elderly residents of nursing homes in Ahvaz city in 201225341604FAJournal Article20200926Background and Objective: Maintaining independence and attention to needs of elder people have always been one of the main goals of care-givers and policy-makers in the field of elderly care. This study was performed to investigate the determination of care dependency among elderly residents of nursing homes in Ahvaz city in 2012.
Materials and Methods: This research was a cross-sectional study of descriptive-analytical type which was carried out on 154 elders with an age over 60 years residing in nursing homes in Ahvaz city. Sampling was performed using stratified sampling method. Data collecting instruments were “Care Dependency Scale”, “Demographic Questionnaire” and “Mini-Mental State Examination”. For data analysis, Chi square test, one-way ANOVA, t-test independent and Pearson correlation coefficient tests were used.
Results: The results indicated that 72.7% of elderly were dependent. There was a high correlation between care dependency and aspects of care dependency scale (p < 0.01). The mean score of care dependency was 47.38 and the mean items score of the care dependency scale for the total sample was 47.25. The variables age (p=0.03), education (p=0.001), having disease (p=0.001) and disability (p=0.032) had significant relationship with care dependency.
Conclusion: In this study, elderly who were better in performing daily living activities certainly needed less care. The knowledge of elderly needs and their capability in performing daily activities may enable care-givers and families to provide more proper services with their need.Background and Objective: Maintaining independence and attention to needs of elder people have always been one of the main goals of care-givers and policy-makers in the field of elderly care. This study was performed to investigate the determination of care dependency among elderly residents of nursing homes in Ahvaz city in 2012.
Materials and Methods: This research was a cross-sectional study of descriptive-analytical type which was carried out on 154 elders with an age over 60 years residing in nursing homes in Ahvaz city. Sampling was performed using stratified sampling method. Data collecting instruments were “Care Dependency Scale”, “Demographic Questionnaire” and “Mini-Mental State Examination”. For data analysis, Chi square test, one-way ANOVA, t-test independent and Pearson correlation coefficient tests were used.
Results: The results indicated that 72.7% of elderly were dependent. There was a high correlation between care dependency and aspects of care dependency scale (p < 0.01). The mean score of care dependency was 47.38 and the mean items score of the care dependency scale for the total sample was 47.25. The variables age (p=0.03), education (p=0.001), having disease (p=0.001) and disability (p=0.032) had significant relationship with care dependency.
Conclusion: In this study, elderly who were better in performing daily living activities certainly needed less care. The knowledge of elderly needs and their capability in performing daily activities may enable care-givers and families to provide more proper services with their need.https://daneshvarmed.shahed.ac.ir/article_1604_a368b0de8b91cfb3f91892fbf1ebd4b2.pdfShahed UniversityDaneshvar Medicine2716-972321620200926The effect of nettle extract and mefenamic acid on reducing the symptoms of menorrhagia patients by joint modelingThe effect of nettle extract and mefenamic acid on reducing the symptoms of menorrhagia patients by joint modeling35421605FAJournal Article20200926Background and Objective: Menorrhagia is considered as one of the most common gynecological problem at child-bearing age of women. Regarding the prevalence of this disease, this study examined the effect of Nettle extract in menorrhagia improvement by statistical modeling.
Materials and Methods: The statistical modeling was performed by data collection from 100 patients with menorrhagia. One-hundred patients were randomly assigned to two groups, i.e. intervention group (nettle and mefenamic acid) and control group (placebo and mefenamic acid) with an equal size of 50. In this study, joint longitudinal and generalized linear model were used for predicting the probability of recovery of women who participated in the study. Joint modeling with common random effects was performed by controlling variables such as age and body mass index to assess the impact of nettle extract on improving menorrhagic patients.
Results: Based on the results, the average number of menstrual days in the third month (second cycles after intervention) were 5.52 ± 1.44 and 6.19 ± 1.82 in nettle extract and control groups, respectively. The difference between the two groups was statistically significant (p =0.023). The chance of improvement who were in nettle group was 1.5 times of control group, but there was no significant difference regarding improvement between the two groups (p=0.347).
Conclusion: In general, joint model is more accurate than the conventional models. Probability of improvement was higher in the intervention group than the control group. Using nettle extract in reducing the number of days of menstrual cycle in patients with menorrhagia has a positive impact.Background and Objective: Menorrhagia is considered as one of the most common gynecological problem at child-bearing age of women. Regarding the prevalence of this disease, this study examined the effect of Nettle extract in menorrhagia improvement by statistical modeling.
Materials and Methods: The statistical modeling was performed by data collection from 100 patients with menorrhagia. One-hundred patients were randomly assigned to two groups, i.e. intervention group (nettle and mefenamic acid) and control group (placebo and mefenamic acid) with an equal size of 50. In this study, joint longitudinal and generalized linear model were used for predicting the probability of recovery of women who participated in the study. Joint modeling with common random effects was performed by controlling variables such as age and body mass index to assess the impact of nettle extract on improving menorrhagic patients.
Results: Based on the results, the average number of menstrual days in the third month (second cycles after intervention) were 5.52 ± 1.44 and 6.19 ± 1.82 in nettle extract and control groups, respectively. The difference between the two groups was statistically significant (p =0.023). The chance of improvement who were in nettle group was 1.5 times of control group, but there was no significant difference regarding improvement between the two groups (p=0.347).
Conclusion: In general, joint model is more accurate than the conventional models. Probability of improvement was higher in the intervention group than the control group. Using nettle extract in reducing the number of days of menstrual cycle in patients with menorrhagia has a positive impact.https://daneshvarmed.shahed.ac.ir/article_1605_f18a6d1cde4b205199de8729a6637b42.pdfShahed UniversityDaneshvar Medicine2716-972321620200926Survey of nutritional and anthropometric status and taste and smell sensitivity of children with Down syndrome in AhvazSurvey of nutritional and anthropometric status and taste and smell sensitivity of children with Down syndrome in Ahvaz43521606FAJournal Article20200926Background and Objective: Down’s syndrome, as the most common chromosomal disorder, is associated with several psychomotor and sensory disorders that can affect the nutritional status of patients. The aim of this study was to determine the nutritional and anthropometric status and taste and smell sensitivity of children with Down syndrome in Ahvaz.
Materials and Methods: This cross-sectional study was done on 58 children with Down syndrome in exceptional and welfare centers of Ahvaz in 2011. Demographic, anthropometric and dietary data were collected by questionnaires, with interviewing with parents. Taste and smell sensitivity was assessed using the Short Sensory Profile questionnaire. Data analysis was carried out using SPSS17.0 software and p < 0.05 was considered significant.
Results: Based on the growth charts for children with Down syndrome, 37.9% and 34.4% of children were above the 75th percentile, respectively in terms of weight to age ratio and BMI. Extracellular water to total body water was significantly higher in girls than boys. Dietary intake of fat was higher than its recommended values and the mean of taste and smell sensitivity score was 13.5±2.0.
Conclusion: More than a third of children were obese according to weight/age and BMI. Eating more high- fat and high-calorie foods and higher sensitivity of them to taste and smell stimuli can be effective in their obesity. In this regard, the need to provide nutritional education to parents and correct dietary pattern is recommended.Background and Objective: Down’s syndrome, as the most common chromosomal disorder, is associated with several psychomotor and sensory disorders that can affect the nutritional status of patients. The aim of this study was to determine the nutritional and anthropometric status and taste and smell sensitivity of children with Down syndrome in Ahvaz.
Materials and Methods: This cross-sectional study was done on 58 children with Down syndrome in exceptional and welfare centers of Ahvaz in 2011. Demographic, anthropometric and dietary data were collected by questionnaires, with interviewing with parents. Taste and smell sensitivity was assessed using the Short Sensory Profile questionnaire. Data analysis was carried out using SPSS17.0 software and p < 0.05 was considered significant.
Results: Based on the growth charts for children with Down syndrome, 37.9% and 34.4% of children were above the 75th percentile, respectively in terms of weight to age ratio and BMI. Extracellular water to total body water was significantly higher in girls than boys. Dietary intake of fat was higher than its recommended values and the mean of taste and smell sensitivity score was 13.5±2.0.
Conclusion: More than a third of children were obese according to weight/age and BMI. Eating more high- fat and high-calorie foods and higher sensitivity of them to taste and smell stimuli can be effective in their obesity. In this regard, the need to provide nutritional education to parents and correct dietary pattern is recommended.https://daneshvarmed.shahed.ac.ir/article_1606_495dabfd0ca768a3c3abd672079f48b6.pdfShahed UniversityDaneshvar Medicine2716-972321620200926Comparison of quality of life in normal and abused childrenComparison of quality of life in normal and abused children53621607FAJournal Article20200926Background and Objective: Social environment affects quality of life and causes physical and psychological disorders in children. Aim of this study was to compare the quality of life in abused and normal children by controlling roles of social anxiety, mood and feeling.
Materials and Methods: The research design was a non-experimental protocol. Participants were 60 children. Using available sampling method, 30 abused children were selected from Center for Treatment of Social and Individual Crisis and a Center of Street Children in Semnan in 2012. They were matched with 30 normal children by age and gender. They completed Pediatric Quality of Life Inventory, Social Phobia and Anxiety Inventory and Short Mood and Feeling Questionnaire for Children.
Results: The results for social phobia and quality of life in physical dimension was different between the two groups. By controlling simultaneous changes of children's mood/feeling on emotional and social dimensions, and also, by controlling social anxiety on emotional and school dimensions, difference of quality of life in these dimensions between the two groups were not statistically significant.
Conclusion: Interventions should focus on social anxiety and mood/feeling for improving the quality of life in emotional dimension, while these interventions should focus on mood/feeling for improving social quality of life and should focus on social anxiety to improve school dimension.Background and Objective: Social environment affects quality of life and causes physical and psychological disorders in children. Aim of this study was to compare the quality of life in abused and normal children by controlling roles of social anxiety, mood and feeling.
Materials and Methods: The research design was a non-experimental protocol. Participants were 60 children. Using available sampling method, 30 abused children were selected from Center for Treatment of Social and Individual Crisis and a Center of Street Children in Semnan in 2012. They were matched with 30 normal children by age and gender. They completed Pediatric Quality of Life Inventory, Social Phobia and Anxiety Inventory and Short Mood and Feeling Questionnaire for Children.
Results: The results for social phobia and quality of life in physical dimension was different between the two groups. By controlling simultaneous changes of children's mood/feeling on emotional and social dimensions, and also, by controlling social anxiety on emotional and school dimensions, difference of quality of life in these dimensions between the two groups were not statistically significant.
Conclusion: Interventions should focus on social anxiety and mood/feeling for improving the quality of life in emotional dimension, while these interventions should focus on mood/feeling for improving social quality of life and should focus on social anxiety to improve school dimension.https://daneshvarmed.shahed.ac.ir/article_1607_9597353e41e6957b5e7aa79214fcb256.pdfShahed UniversityDaneshvar Medicine2716-972321620200926Comparison of the anesthetic effect of epidural lidocaine and tramadol and their combination in rabbitComparison of the anesthetic effect of epidural lidocaine and tramadol and their combination in rabbit63701608FAJournal Article20200926Background and Objective: The aim of this research was to compare the anesthetic effect of epidural lidocaine and tramadol and their combination in rabbit as a model for further research on methods of epidural anesthesia in humans.
Materials and Methods: This experimental study was conducted on 12 New Zealand white rabbits that were divided into 3 groups of 4. In the first experimental group (L), 4 mg/kg of lidocaine 2% was used. For the second group (T), 4.4 mg/kg of tramadol was used. Third group (TL) received a combination of lidocaine (2 mg/kg) and tramadol (2.2 mg/kg). Sensory block, motor block, heart rate, respiratory rate and rectal temperature, 10 min before injection and at intervals of 10 minutes up to 90 minutes after injection was measured. SPSS statistical analysis software and paired sample t-test were used and significance level was p < 0.05).
Results: Based on obtained results, lidocaine group showed delayed onset of numbness and immobility (3±0.3 min) versus tramadol (1.25 ± 0.5 min) and tramadol+lidocaine (1 min) (p < 0.05). Also, the duration of numbness and immobility in tramadol group (7.13 ±5.2 min) significantly reduced as compared to the lidocaine+tramadol (20±1.14 min) and lidocaine groups (30±10 min) (p < 0.05).
Conclusion: In this study, lidocaine showed better results than tramadol and combination of lidocaine and tramadol as an epidural agent in rabbits.Background and Objective: The aim of this research was to compare the anesthetic effect of epidural lidocaine and tramadol and their combination in rabbit as a model for further research on methods of epidural anesthesia in humans.
Materials and Methods: This experimental study was conducted on 12 New Zealand white rabbits that were divided into 3 groups of 4. In the first experimental group (L), 4 mg/kg of lidocaine 2% was used. For the second group (T), 4.4 mg/kg of tramadol was used. Third group (TL) received a combination of lidocaine (2 mg/kg) and tramadol (2.2 mg/kg). Sensory block, motor block, heart rate, respiratory rate and rectal temperature, 10 min before injection and at intervals of 10 minutes up to 90 minutes after injection was measured. SPSS statistical analysis software and paired sample t-test were used and significance level was p < 0.05).
Results: Based on obtained results, lidocaine group showed delayed onset of numbness and immobility (3±0.3 min) versus tramadol (1.25 ± 0.5 min) and tramadol+lidocaine (1 min) (p < 0.05). Also, the duration of numbness and immobility in tramadol group (7.13 ±5.2 min) significantly reduced as compared to the lidocaine+tramadol (20±1.14 min) and lidocaine groups (30±10 min) (p < 0.05).
Conclusion: In this study, lidocaine showed better results than tramadol and combination of lidocaine and tramadol as an epidural agent in rabbits.https://daneshvarmed.shahed.ac.ir/article_1608_faafda66202d234463057972460c04f5.pdfShahed UniversityDaneshvar Medicine2716-972321620200926The effect of somatosensory intervention training on balance in healthy elderlyThe effect of somatosensory intervention training on balance in healthy elderly71761609FAJournal Article20200926Background and Objective: The somatosensory system plays an important role in balance control and age-related decline in somatosensory function has been implicated in falls incidence. Textured surfaces may provide an inexpensive and accessible means to enhance somatosensory input. The aim of this study was to examine the effect of somatosensory exercise on balance of elderly.
Materials and Methods: A total of 16 healthy elderly men volunteered for this study and were divided into two groups of somatosensory and control. In the pre and post subjects tests (limit of stability) of Biodex system was the difficulty level of 8. Exercises for both groups were performed 3 weeks, 5 sessions per week. Training session time was 1 hour of exercise which was described by Suzuki with the exception that somatosensory group exercises on the textured surface and control group exercises performed on a flat surface.
Results: Results of repeated measures ANOVA showed that exercise walking on textured surfaces affects the balance (F =22.567, p=0.0001). There was also a significant difference between the control and somatosensory groups (F=3.329, p=0.048).
Conclusion: According to these research findings, walking practice on textured surfaces may stimulate pressure receptors in the feet and increase sensory input from the plantar that leads to improved balance in the elderly.Background and Objective: The somatosensory system plays an important role in balance control and age-related decline in somatosensory function has been implicated in falls incidence. Textured surfaces may provide an inexpensive and accessible means to enhance somatosensory input. The aim of this study was to examine the effect of somatosensory exercise on balance of elderly.
Materials and Methods: A total of 16 healthy elderly men volunteered for this study and were divided into two groups of somatosensory and control. In the pre and post subjects tests (limit of stability) of Biodex system was the difficulty level of 8. Exercises for both groups were performed 3 weeks, 5 sessions per week. Training session time was 1 hour of exercise which was described by Suzuki with the exception that somatosensory group exercises on the textured surface and control group exercises performed on a flat surface.
Results: Results of repeated measures ANOVA showed that exercise walking on textured surfaces affects the balance (F =22.567, p=0.0001). There was also a significant difference between the control and somatosensory groups (F=3.329, p=0.048).
Conclusion: According to these research findings, walking practice on textured surfaces may stimulate pressure receptors in the feet and increase sensory input from the plantar that leads to improved balance in the elderly.https://daneshvarmed.shahed.ac.ir/article_1609_a2cc63e065705fe938a4dda49092966f.pdf