Shahed UniversityDaneshvar Medicine2716-972320420121022The effect of acupressure on pain severity of chest tube removal in patients with open heart surgery in intensive care unitThe effect of acupressure on pain severity of chest tube removal in patients with open heart surgery in intensive care unit1121533FAFaridehBastaniHemmatallahMomenabadiMohammad-TaghiSafdariHamidHaghaniJournal Article20200926 Background and Objective: Pain due to chest tube removal (CTR) is a major
complaint among patients who undergo open heart surgery. This study was carried
out to investigate the effect of acupressure on pain intensity after chest tube
removal in patients with open heart surgery in intensive care unit (ICU). Materials and Methods: This research study was a randomized controlled
clinical trial. The subjects consisted of 100 patients with open heart surgery
and two or more chest tubes, hospitalized in the intensive care unit of
Shariati Hospital in Tehran. The sampling method was consecutive and the
patients were randomly allocated to two groups, i.e. the control and
experimental groups. Experimental group received acupressure and control group
received touch on the same point. The tool for data collection was composed of
demographic data and pain intensity of the participants. Pain intensity was
measured 10 minutes before (baseline), immediately and 15 minutes following
chest tube removal by using the 0-10 numeric Visual Analogue rating scale. Data
were analyzed with descriptive and inferential statistics using SPSS software
(Version 15). Results: One
hundred patients participated in the study and no differences were found
regarding the participants' personal characteristics and intensity of
pre-intervention pain. There was also a significant difference between the two
groups regarding pain intensity (p = 0.01) immediately after the chest tube
removal. Conclusion: The obtained
results indicated that acupressure is an effective non-pharmacologic method for control of the immediate pain due to
chest tube removal in post-cardiac surgery patients. Background and Objective: Pain due to chest tube removal (CTR) is a major
complaint among patients who undergo open heart surgery. This study was carried
out to investigate the effect of acupressure on pain intensity after chest tube
removal in patients with open heart surgery in intensive care unit (ICU). Materials and Methods: This research study was a randomized controlled
clinical trial. The subjects consisted of 100 patients with open heart surgery
and two or more chest tubes, hospitalized in the intensive care unit of
Shariati Hospital in Tehran. The sampling method was consecutive and the
patients were randomly allocated to two groups, i.e. the control and
experimental groups. Experimental group received acupressure and control group
received touch on the same point. The tool for data collection was composed of
demographic data and pain intensity of the participants. Pain intensity was
measured 10 minutes before (baseline), immediately and 15 minutes following
chest tube removal by using the 0-10 numeric Visual Analogue rating scale. Data
were analyzed with descriptive and inferential statistics using SPSS software
(Version 15). Results: One
hundred patients participated in the study and no differences were found
regarding the participants' personal characteristics and intensity of
pre-intervention pain. There was also a significant difference between the two
groups regarding pain intensity (p = 0.01) immediately after the chest tube
removal. Conclusion: The obtained
results indicated that acupressure is an effective non-pharmacologic method for control of the immediate pain due to
chest tube removal in post-cardiac surgery patients. https://daneshvarmed.shahed.ac.ir/article_1533_58e1e28cc9d499b1bc4ac4676077f0b4.pdfShahed UniversityDaneshvar Medicine2716-972320420121022Delivery of gene therapy construct by polyplexes nanoparticle (targeted polyethyleneimine) to colon cancer cellsDelivery of gene therapy construct by polyplexes nanoparticle (targeted polyethyleneimine) to colon cancer cells13261534FAFatemehRahbarizadehNegarAsle RasouliFarnoushJafari Iri SoflaDavoudAhmadvandJournal Article20200926 Background and Objectives: The aim of this
study was preparation of polyethyleneimine (PEI) nanoparticles targeted with
anti-TAG72 nanobody for delivery of t-Bid gene construct into the human colonic adenocarcinoma cells. Materials and Methods: First of all, purified recombinant nanobody was verified by
SDS-PAGE, western blotting and ELISA. Targeted polyplexes were constructed by
reacting polyethylene glycol (PEG) with PEI and covalent bonding of nanobody to
nanoparticles. Surface charge and size of the resulting nanoparticles were
evaluated by Malvern zeta sizer and nanosight instruments. Efficiency of
constructed gene vector for killer gene delivery into the colonic
adenocarcinoma cells was assessed using real time PCR assay. Results:
Production of nanoparticles with
the average size of 168 nm and +7.18 surface charge was confirmed by nanosight
and Malvern zeta sizer. Gel retardation assay verified the efficiency of
carrier for pDNA complexation. Real time PCR results confirmed the targeted
gene expression in the cancerous cell lines. Conclusion: Results of this study confirmed the
efficiency of targeted polyplexes in gene delivery and their potency for
targeted gene delivery into the cells. Background and Objectives: The aim of this
study was preparation of polyethyleneimine (PEI) nanoparticles targeted with
anti-TAG72 nanobody for delivery of t-Bid gene construct into the human colonic adenocarcinoma cells. Materials and Methods: First of all, purified recombinant nanobody was verified by
SDS-PAGE, western blotting and ELISA. Targeted polyplexes were constructed by
reacting polyethylene glycol (PEG) with PEI and covalent bonding of nanobody to
nanoparticles. Surface charge and size of the resulting nanoparticles were
evaluated by Malvern zeta sizer and nanosight instruments. Efficiency of
constructed gene vector for killer gene delivery into the colonic
adenocarcinoma cells was assessed using real time PCR assay. Results:
Production of nanoparticles with
the average size of 168 nm and +7.18 surface charge was confirmed by nanosight
and Malvern zeta sizer. Gel retardation assay verified the efficiency of
carrier for pDNA complexation. Real time PCR results confirmed the targeted
gene expression in the cancerous cell lines. Conclusion: Results of this study confirmed the
efficiency of targeted polyplexes in gene delivery and their potency for
targeted gene delivery into the cells. https://daneshvarmed.shahed.ac.ir/article_1534_88673f1f4e9d9db18c6a29b21f7a8c89.pdfShahed UniversityDaneshvar Medicine2716-972320420121022The effect of aerobic training with or without calorie restriction on lipid profile in adult obese femalesThe effect of aerobic training with or without calorie restriction on lipid profile in adult obese females27341535FAMandanaGholami0000-0001-8960-4123LeilaSabaghian-RadElhamEftekhariArdeshirZafariJournal Article20200926 Background and Objective: Cardiovascular diseases are one of the causes of death in
obese women. This study was conducted to examine the effects
of diet, exercise, and both on serum lipids and lipoproteins in
obese females. Materials and Methods: In this study, 45 sedentary and healthy obese females (29.01±2.55 y, body mass index 33.11±1.66 kg.m-2) were randomly divided into four
groups: diet alone (500 kcal less than daily energy expenditure, n=10),
exercise alone (six 60 minute per week 60% - 80% maximum
heart rate, n=11), exercise and diet (250 kcal less than daily energy expenditure,
four 60 minute per week 60% - 80% maximum heart rate, n=12), and control
(n=12). Body composition, serum lipids, and lipoproteins were measured in all
subjects at baseline and after an 8-week intervention period. The data were
analyzed by descriptive and inferential statistics, which was accomplished by
one-way ANOVA followed by the LSD post-hoc test (p < 0.05). Results: Subjects in the diet and exercise group lost 5.47±0.6 kg and those in the diet group lost 5.54±0.7 kg of their body mass. No significant changes were observed in the exercise group
relative to the control group.
After 8 weeks of intervention, serum cholesterol and triacylglycerol decreased in both
diet and exercise and diet groups and it was most strongly related to weight loss. Conclusion: Diet and exercise are the most
effective means of reducing lipid and lipoprotein risk
factors in obese women. Background and Objective: Cardiovascular diseases are one of the causes of death in
obese women. This study was conducted to examine the effects
of diet, exercise, and both on serum lipids and lipoproteins in
obese females. Materials and Methods: In this study, 45 sedentary and healthy obese females (29.01±2.55 y, body mass index 33.11±1.66 kg.m-2) were randomly divided into four
groups: diet alone (500 kcal less than daily energy expenditure, n=10),
exercise alone (six 60 minute per week 60% - 80% maximum
heart rate, n=11), exercise and diet (250 kcal less than daily energy expenditure,
four 60 minute per week 60% - 80% maximum heart rate, n=12), and control
(n=12). Body composition, serum lipids, and lipoproteins were measured in all
subjects at baseline and after an 8-week intervention period. The data were
analyzed by descriptive and inferential statistics, which was accomplished by
one-way ANOVA followed by the LSD post-hoc test (p < 0.05). Results: Subjects in the diet and exercise group lost 5.47±0.6 kg and those in the diet group lost 5.54±0.7 kg of their body mass. No significant changes were observed in the exercise group
relative to the control group.
After 8 weeks of intervention, serum cholesterol and triacylglycerol decreased in both
diet and exercise and diet groups and it was most strongly related to weight loss. Conclusion: Diet and exercise are the most
effective means of reducing lipid and lipoprotein risk
factors in obese women. https://daneshvarmed.shahed.ac.ir/article_1535_11f0114f5c9b9e6761cd073058948470.pdfShahed UniversityDaneshvar Medicine2716-972320420121022The effect of ginger on pregnancy vomiting: A double blind randomized clinical trialThe effect of ginger on pregnancy vomiting: A double blind randomized clinical trial35421536FASeyedeh NavabehHosseinkhaniAhiaGarshsbiJournal Article20200926 Background and Objective:
Pregnancy-induced vomiting reduces women's quality of life. Ginger as herbal
medicine has been used to treat pregnancy vomiting. The aim of this study was
to determine the effect of ginger on reducing pregnancy vomiting. Materials and Methods: This survey was a double blind randomized placebo trial
with control group. For this purpose, 135 pregnant women till 20 weeks of gestation suffering from
vomiting were participated. They were randomly and equally divided into placebo
(starch), control, and ginger (365 mg capsules, 3 times/day for 4 days) groups.
The episods of vomiting were recorded before and after the study (follow up
period) and statistical analysis was done. Results: There was not a significant difference between the 3
groups about matching items. Meanwhile, in ginger group, there was a
significant difference before and after ginger administration regarding number
of vomiting episodes (p < 0.001). In placebo group, number of vomiting episodes
had also a significant difference before and after intervention at days 1-4
(p < 0.005). Comparison of the three
groups showed that there was a significant difference between number of
vomiting episodes after intervention at days 1-4 (p < 0.005). In addition,
comparison of ginnger and placebo groups showed that a significant difference
exists at second, third, and fourth days (p < 0.05). Conclusion:
Ginger is effective in reduction of pregnancy vomiting Background and Objective:
Pregnancy-induced vomiting reduces women's quality of life. Ginger as herbal
medicine has been used to treat pregnancy vomiting. The aim of this study was
to determine the effect of ginger on reducing pregnancy vomiting. Materials and Methods: This survey was a double blind randomized placebo trial
with control group. For this purpose, 135 pregnant women till 20 weeks of gestation suffering from
vomiting were participated. They were randomly and equally divided into placebo
(starch), control, and ginger (365 mg capsules, 3 times/day for 4 days) groups.
The episods of vomiting were recorded before and after the study (follow up
period) and statistical analysis was done. Results: There was not a significant difference between the 3
groups about matching items. Meanwhile, in ginger group, there was a
significant difference before and after ginger administration regarding number
of vomiting episodes (p < 0.001). In placebo group, number of vomiting episodes
had also a significant difference before and after intervention at days 1-4
(p < 0.005). Comparison of the three
groups showed that there was a significant difference between number of
vomiting episodes after intervention at days 1-4 (p < 0.005). In addition,
comparison of ginnger and placebo groups showed that a significant difference
exists at second, third, and fourth days (p < 0.05). Conclusion:
Ginger is effective in reduction of pregnancy vomitinghttps://daneshvarmed.shahed.ac.ir/article_1536_cc6e6974245660d66994cbb8d4574892.pdfShahed UniversityDaneshvar Medicine2716-972320420121022Immunocytochemical evaluation of expression of neuroepithelial, neural and GABAergic-like neuron markers in transdifferentiated BMSCs using appropriate in vitro inducersImmunocytochemical evaluation of expression of neuroepithelial, neural and GABAergic-like neuron markers in transdifferentiated BMSCs using appropriate in vitro inducers43521537FAShahramDarabiTakiTiraihiAlirezaDelshadMajidSadeghizadehJournal Article20200926 Background and Objective: Bone
marrow stromal cells (BMSCs) have been
shown to be a feasible option for cell therapy. There is increasing evidence that BMSCs have the potential of differentiation into GABAergic like
neuron cells (GLNCs) in vitro under appropriate induction protocols. GABAergic
dysfunction is implicated in several neurological disorders. The present study
provides evidence for an in vitro potential of BMSCs to transdifferentiate
into GLNCs. Materials and Methods: BMSCs were
collected from long bones of adult Sprague–Dawley rats, following three passages of cell culture, BMSCs
were preinduced using 1 mM β-mercaptoethanol (βME) and 10 µM retinoic acid
(RA), they were then induced by creatine 5 mM in different days as an inducer.
In preinduction and induction stages, the effects of these inducers on
differentiation of BMSCs were evaluated by immunohistochemistry and RT-PCR. Results: Our results indicated that
after induction stage, a high percentage of GLNCs is expressed. According to
GABAergic markers (GABA antibody), 5 mM creatine and 10 µM RA after 4 days had
a prominent role on differentiation of BMSCs to GLNCs. Conclusion: βME, RA and creatine induce
differentiation of BMSCs into GLNCs. Background and Objective: Bone
marrow stromal cells (BMSCs) have been
shown to be a feasible option for cell therapy. There is increasing evidence that BMSCs have the potential of differentiation into GABAergic like
neuron cells (GLNCs) in vitro under appropriate induction protocols. GABAergic
dysfunction is implicated in several neurological disorders. The present study
provides evidence for an in vitro potential of BMSCs to transdifferentiate
into GLNCs. Materials and Methods: BMSCs were
collected from long bones of adult Sprague–Dawley rats, following three passages of cell culture, BMSCs
were preinduced using 1 mM β-mercaptoethanol (βME) and 10 µM retinoic acid
(RA), they were then induced by creatine 5 mM in different days as an inducer.
In preinduction and induction stages, the effects of these inducers on
differentiation of BMSCs were evaluated by immunohistochemistry and RT-PCR. Results: Our results indicated that
after induction stage, a high percentage of GLNCs is expressed. According to
GABAergic markers (GABA antibody), 5 mM creatine and 10 µM RA after 4 days had
a prominent role on differentiation of BMSCs to GLNCs. Conclusion: βME, RA and creatine induce
differentiation of BMSCs into GLNCs. https://daneshvarmed.shahed.ac.ir/article_1537_4ae72cef539a8e707edabd687d1bf940.pdfShahed UniversityDaneshvar Medicine2716-972320420121022The effect of 6-month aerobic exercise on levels of serum immunoglobulins in untrained middle-aged womenThe effect of 6-month aerobic exercise on levels of serum immunoglobulins in untrained middle-aged women53601538FANahidBijeh0000-0001-7039-3549KeyvanHejaziJournal Article20200926 Background and Objective: The results of researches have shown that heavy
and prolonged exercise increases the risk of upper respiratory tract infection
in athletics. The aim of this study was to determine the effect of a 6 month
aerobic exercise on the levels of serum immunoglobulin in untrained middle-aged
women. Materials and Methods: For this study, nineteen healthy female
middle-aged personnel of Ferdowsi university of Mashhad were selected by convenience sampling method
and were randomly divided into two experimental (11 people) and control (8
people) groups. The exercise protocol included aerobic exercise training
lasting for 6 months and 3 sessions per week and every session lasted for 60
minutes and with an intensity of 55-65 percent of heart rate reserve. Blood
samples were taken and serum immunoglobulin (IgA, IgM, and IgG) were measured
before and after 6 month aerobic training period. For comparison of means within
and between groups, paired-samples t test and independent t-test were used,
respectively at a significance level of p < 0.05. Results: The findings showed that the level of serum immunoglobulin G in
middle-aged women reduced significantly. However, the levels of immunoglobulin
M and A during this period did not significantly change. Conclusion: It is concluded that intensity and duration of exercise affect the
performance of the immune system and increase the risk of infection.
Researchers believed that long and intensive exercises weaken the immune system
while moderate and short exercises make this system strengthened. Background and Objective: The results of researches have shown that heavy
and prolonged exercise increases the risk of upper respiratory tract infection
in athletics. The aim of this study was to determine the effect of a 6 month
aerobic exercise on the levels of serum immunoglobulin in untrained middle-aged
women. Materials and Methods: For this study, nineteen healthy female
middle-aged personnel of Ferdowsi university of Mashhad were selected by convenience sampling method
and were randomly divided into two experimental (11 people) and control (8
people) groups. The exercise protocol included aerobic exercise training
lasting for 6 months and 3 sessions per week and every session lasted for 60
minutes and with an intensity of 55-65 percent of heart rate reserve. Blood
samples were taken and serum immunoglobulin (IgA, IgM, and IgG) were measured
before and after 6 month aerobic training period. For comparison of means within
and between groups, paired-samples t test and independent t-test were used,
respectively at a significance level of p < 0.05. Results: The findings showed that the level of serum immunoglobulin G in
middle-aged women reduced significantly. However, the levels of immunoglobulin
M and A during this period did not significantly change. Conclusion: It is concluded that intensity and duration of exercise affect the
performance of the immune system and increase the risk of infection.
Researchers believed that long and intensive exercises weaken the immune system
while moderate and short exercises make this system strengthened. https://daneshvarmed.shahed.ac.ir/article_1538_6338620564634bd731bafb460967c854.pdfShahed UniversityDaneshvar Medicine2716-972320420121022Methadone and valproate combination effect on acquisition and expression of morphine dependence and tolerance in male miceMethadone and valproate combination effect on acquisition and expression of morphine dependence and tolerance in male mice61681539FASamiraVahidi0009-0000-9269-2945MohsenKhalili1111-2222-3333-444XZahraKiasalariEsmatYaghoutpoorJournal Article20200926 Background and
Objective:
According to the problem of dependence and tolerance in addicted
patients, the inefficiency of existing treatments and the new sciences
recommendation of drug combination therapy for diseases in modern pharmacology, the
present study examined the effects of methadone and valproate combination on morphine
tolerance and dependence. Materials and Methods: Ninety-eight
male mice were divided into following groups: saline, morphine, methadone, valproate,
three groups of valproate+methadone, i.e 1 to 1, 2 to 1 and 1 to 2 ratio.
Except saline group, other groups received escalating dose of morphine for 8 consecutive days. In acquisition group, drugs were injected for 30 minutes before morphine administration. But in expression group, the drugs were used only at 8th day (test
day) as mentioned method. Morphine tolerance was
measured by tail immersion test and for the dependence, naloxone-induced
withdrawal signs assessment was applied. Results: Jumping
behavior as a main dependence signs in both acquisition
and expression
significantly reduced in methadone1+ valproate2 treatment groups. Also,
acquisition and expression in tolerance evaluation significantly decreased
in valproate and methadone1+valproate2 more than other groups. Conclusion: Our results showed that probably methadone and
valproate combination treatment could reduce tolerance and dependence more than single valproate or methadone
treatments. Background and
Objective:
According to the problem of dependence and tolerance in addicted
patients, the inefficiency of existing treatments and the new sciences
recommendation of drug combination therapy for diseases in modern pharmacology, the
present study examined the effects of methadone and valproate combination on morphine
tolerance and dependence. Materials and Methods: Ninety-eight
male mice were divided into following groups: saline, morphine, methadone, valproate,
three groups of valproate+methadone, i.e 1 to 1, 2 to 1 and 1 to 2 ratio.
Except saline group, other groups received escalating dose of morphine for 8 consecutive days. In acquisition group, drugs were injected for 30 minutes before morphine administration. But in expression group, the drugs were used only at 8th day (test
day) as mentioned method. Morphine tolerance was
measured by tail immersion test and for the dependence, naloxone-induced
withdrawal signs assessment was applied. Results: Jumping
behavior as a main dependence signs in both acquisition
and expression
significantly reduced in methadone1+ valproate2 treatment groups. Also,
acquisition and expression in tolerance evaluation significantly decreased
in valproate and methadone1+valproate2 more than other groups. Conclusion: Our results showed that probably methadone and
valproate combination treatment could reduce tolerance and dependence more than single valproate or methadone
treatments. https://daneshvarmed.shahed.ac.ir/article_1539_2fa25a4a14d4c4184153ff28404f197b.pdfShahed UniversityDaneshvar Medicine2716-972320420121022The effect of apigenin on some oxidative stress-associated factors in renal tissue of streptozotocin-diabetic ratsThe effect of apigenin on some oxidative stress-associated factors in renal tissue of streptozotocin-diabetic rats69761540FARezaAfsharMehrdadRoghani0000-0002-9209-8484FatemehPoorasad MehrabaniJournal Article20200926 Background and Objective: Diabetes mellitus accompanies enhanced
oxidative stress and decreased activity of antioxidant defense system. Due to
the significant role of enhanced oxidative stress in development of renal
damage and nephropathy in diabetes and with regard to antidiabetic and antioxidant
effect of apigenin, this study was conducted to evaluate the effect of this
flavonoid on the level of some oxidative stress-associated factors in kidney
tissue of diabetic rats. Materials and Methods: Male rats were divided into 4 groups,
i.e. control, apigenin-treated control, diabetic, and apigenin-treated diabetic
groups. Apigenin was administered at a dose of 10 mg/kg for three weeks
starting seven days after diabetes induction using streptozotocin. Tissue level
of malondialdehyde (MDA) and nitrite and nitrate and activity of superoxide
dismutase (SOD) in kidney tissue were measured at the end of the study. Results: Diabetic rats had a significant increase in tissue level
of malondialdehyde (p < 0.01) and nitrite (p < 0.05) and a lower level of SOD
activity (p < 0.01) as compared to control group and treatment of diabetic
rats with apigenin did not significantly reduce MDA and nitrite level and also
did not significantly enhance SOD activity in diabetic group. Conclusion: Chronic apigenin treatment could not
significantly change some measured markers of oxidative stress in renal tissue
in this study from diabetic rats and its antioxidant effect is not potent
enough to prevent renal damage in streptozotocin-induced model of diabetes. Background and Objective: Diabetes mellitus accompanies enhanced
oxidative stress and decreased activity of antioxidant defense system. Due to
the significant role of enhanced oxidative stress in development of renal
damage and nephropathy in diabetes and with regard to antidiabetic and antioxidant
effect of apigenin, this study was conducted to evaluate the effect of this
flavonoid on the level of some oxidative stress-associated factors in kidney
tissue of diabetic rats. Materials and Methods: Male rats were divided into 4 groups,
i.e. control, apigenin-treated control, diabetic, and apigenin-treated diabetic
groups. Apigenin was administered at a dose of 10 mg/kg for three weeks
starting seven days after diabetes induction using streptozotocin. Tissue level
of malondialdehyde (MDA) and nitrite and nitrate and activity of superoxide
dismutase (SOD) in kidney tissue were measured at the end of the study. Results: Diabetic rats had a significant increase in tissue level
of malondialdehyde (p < 0.01) and nitrite (p < 0.05) and a lower level of SOD
activity (p < 0.01) as compared to control group and treatment of diabetic
rats with apigenin did not significantly reduce MDA and nitrite level and also
did not significantly enhance SOD activity in diabetic group. Conclusion: Chronic apigenin treatment could not
significantly change some measured markers of oxidative stress in renal tissue
in this study from diabetic rats and its antioxidant effect is not potent
enough to prevent renal damage in streptozotocin-induced model of diabetes. https://daneshvarmed.shahed.ac.ir/article_1540_f2beebf33b77d61b302a71aaae5a53d0.pdfShahed UniversityDaneshvar Medicine2716-972320420121022The relationship between use of communication skills and job satisfaction of nursesThe relationship between use of communication skills and job satisfaction of nurses77821541FAHosseinMahmoudiAbouzarSoori LakiMasoumehBoulhasaniMohammad-JafarSepahvandJournal Article20200926 Background and Objective: Effective communication is a vital
component of nursing care. Given the importance of communication skills and its
impact on job satisfaction of nurses, this study was conducted to investigate
the relationships between communication skills and job satisfaction in nurses. Materials and Methods: This research was a
descriptive–correlative study that was conducted in 2012 and randomly utilized
242 nurses in Tehran. Data were collected by communication skills and job
satisfaction questionnaire. Data were analyzed using Chi square test and SPSS
17 software. Results: The findings indicated that a significant positive
correlation exists between communication skills with job satisfaction. Two
characteristics of the components of job satisfaction (job and relationship
with colleagues) was significantly associated with nurses' communication skills
(p < 0.001). Conclusion: According to obtained results, a positive
correlation exists between communication skills and job satisfaction. Thus,
communication skill training programs are recommended for nurses to improve the
quality of nursing care. Background and Objective: Effective communication is a vital
component of nursing care. Given the importance of communication skills and its
impact on job satisfaction of nurses, this study was conducted to investigate
the relationships between communication skills and job satisfaction in nurses. Materials and Methods: This research was a
descriptive–correlative study that was conducted in 2012 and randomly utilized
242 nurses in Tehran. Data were collected by communication skills and job
satisfaction questionnaire. Data were analyzed using Chi square test and SPSS
17 software. Results: The findings indicated that a significant positive
correlation exists between communication skills with job satisfaction. Two
characteristics of the components of job satisfaction (job and relationship
with colleagues) was significantly associated with nurses' communication skills
(p < 0.001). Conclusion: According to obtained results, a positive
correlation exists between communication skills and job satisfaction. Thus,
communication skill training programs are recommended for nurses to improve the
quality of nursing care. https://daneshvarmed.shahed.ac.ir/article_1541_b663a9fca9e0f765bc500cc2d09510de.pdfShahed UniversityDaneshvar Medicine2716-972320420121022Study of biocompatibility of electrospun chitosan-based nanofiber co-cultured with bone marrow stromal cellsStudy of biocompatibility of electrospun chitosan-based nanofiber co-cultured with bone marrow stromal cells181542FAAsgarEmamgholiGholam RezaKakaMinooSadriSeyed HomayoonSadraieDavoodZolfaghariZahraBorborJournal Article20200926 Background and Objective: Several studies have been performed to achieve a scaffold for growing stem cells.
The purpose of the study was to provide a biodegradable scaffold of chitosan -
poly ethylene oxide (PEO) with the ability for growing, proliferation, un-differentiation
and apoptosis of bone marrow stromal cells (BMSCs).
Materials
and Methods: First,
formation of chitosan-PEO nanofibers
composed of 90 to 10 and 80 to 20 per electro technique were studied by scanning
electron microscope (SEM). These scaffolds were located on 1% gelatin in
24-well plates and were then steriled. Femoral BMSCs of rats were
cultured on scaffolds after two passages from the house empty plate as
controls. BMSCs proliferation, differentiation and apoptosis were
studied in days II, IV and VI. Results: The results showed that the morphology of cells was maintained on scaffolds similar
to controls. The rate of cell proliferation on the scaffold on consecutive days increased in cultured cells of control group < /span> but the differences were not significant. The results also showed that at the end of the six days, BMSCs differentiation and the percentage of cell death on the scaffold were similar with cultured cells in control group.
Conclusion: P < /span>roliferation, un-differentiation and no
apoptosis of BMSCs on biodegradable chitosan-PEO nanofiber are obtained as a model that can be used in tissue engineering and cell therapy Background and Objective: Several studies have been performed to achieve a scaffold for growing stem cells.
The purpose of the study was to provide a biodegradable scaffold of chitosan -
poly ethylene oxide (PEO) with the ability for growing, proliferation, un-differentiation
and apoptosis of bone marrow stromal cells (BMSCs).
Materials
and Methods: First,
formation of chitosan-PEO nanofibers
composed of 90 to 10 and 80 to 20 per electro technique were studied by scanning
electron microscope (SEM). These scaffolds were located on 1% gelatin in
24-well plates and were then steriled. Femoral BMSCs of rats were
cultured on scaffolds after two passages from the house empty plate as
controls. BMSCs proliferation, differentiation and apoptosis were
studied in days II, IV and VI. Results: The results showed that the morphology of cells was maintained on scaffolds similar
to controls. The rate of cell proliferation on the scaffold on consecutive days increased in cultured cells of control group < /span> but the differences were not significant. The results also showed that at the end of the six days, BMSCs differentiation and the percentage of cell death on the scaffold were similar with cultured cells in control group.
Conclusion: P < /span>roliferation, un-differentiation and no
apoptosis of BMSCs on biodegradable chitosan-PEO nanofiber are obtained as a model that can be used in tissue engineering and cell therapyhttps://daneshvarmed.shahed.ac.ir/article_1542_59d724a0f2254b9a92b4db0c1fc4d014.pdfShahed UniversityDaneshvar Medicine2716-972320420121022The effect of chronic carnosine treatment on serum levels of glucose and lipids and blood pressure in an experimental model of hyperlipidemia in miceThe effect of chronic carnosine treatment on serum levels of glucose and lipids and blood pressure in an experimental model of hyperlipidemia in mice9161543FAFaramarzFallahiMehrdadRoghani0000-0002-9209-8484ZahraAhmadiJournal Article20200926 Background and Objective: Chronic hyperlipidemia accompanies
various complications in the body. With regard to protective and beneficial
effect of carnosine in metabolic disorders, this study was conducted to
evaluate its effect on serum lipids and blood pressure in an experimental model
of hyperlipidemia in mice. Materials and Methods: Mice were divided into five groups,
i.e. control, high-dose carnosine-treated control, hyperlipidemic, and two
carnosine-treated (125 and 250 mg/kg) hyperlipidemic groups. Carnosine was
administered i.p. from 8th week after hyperlipidemia induction for 4 weeks. Results: Carnosine did not cause any
significant reduction of serum glucose, there was a significant increase in
serum total cholesterol and triglyceride in hyperlipidemic group as compared to
control (p < 0.05-0.01) and carnosine at a high dose significantly decreased
it (p < 0.05). Regarding serum HDL cholesterol, carnosine treatment did not significantly
change it. In contrast, hyperlipidemia significantly increased LDL-cholesterol
(p < 0.05) and carnosine at a dose of 250 mg/kg significantly lowered it
(p < 0.05). In addition, hyperlipidemic mice has a significantly higher
systolic blood pressure (p < 0.05) and carnosine treatment did not
significantly change it. Conclusion: Administration of carnosine to
hyperlipidemic mice does not affect serum glucose level and systolic blood
pressure and significantly lowers serum total cholesterol, LDL-cholesterol, and
triglyceride level. Background and Objective: Chronic hyperlipidemia accompanies
various complications in the body. With regard to protective and beneficial
effect of carnosine in metabolic disorders, this study was conducted to
evaluate its effect on serum lipids and blood pressure in an experimental model
of hyperlipidemia in mice. Materials and Methods: Mice were divided into five groups,
i.e. control, high-dose carnosine-treated control, hyperlipidemic, and two
carnosine-treated (125 and 250 mg/kg) hyperlipidemic groups. Carnosine was
administered i.p. from 8th week after hyperlipidemia induction for 4 weeks. Results: Carnosine did not cause any
significant reduction of serum glucose, there was a significant increase in
serum total cholesterol and triglyceride in hyperlipidemic group as compared to
control (p < 0.05-0.01) and carnosine at a high dose significantly decreased
it (p < 0.05). Regarding serum HDL cholesterol, carnosine treatment did not significantly
change it. In contrast, hyperlipidemia significantly increased LDL-cholesterol
(p < 0.05) and carnosine at a dose of 250 mg/kg significantly lowered it
(p < 0.05). In addition, hyperlipidemic mice has a significantly higher
systolic blood pressure (p < 0.05) and carnosine treatment did not
significantly change it. Conclusion: Administration of carnosine to
hyperlipidemic mice does not affect serum glucose level and systolic blood
pressure and significantly lowers serum total cholesterol, LDL-cholesterol, and
triglyceride level. https://daneshvarmed.shahed.ac.ir/article_1543_00a41ad55bb791ca69700570f16a5708.pdfShahed UniversityDaneshvar Medicine2716-972320420121022The effect of aerobic exercise on plasma visfatin levels in men with type 2diabetes treated with metforminThe effect of aerobic exercise on plasma visfatin levels in men with type 2diabetes treated with metformin17241544FASeyed MohammadAzimiHamidMarefatiGholamrezaYousefzadehMajidMohajeriJournal Article20200926 Background
and Objective: Visfatin is a
recently discovered adipokine. Previous studies have shown a direct
relationship between plasma visfatin levels and type 2 diabetes mellitus. The current study was conducted to
investigate the effect of aerobic exercise on
plasma level of visfatin in type 2 diabetic men treated with metformin. Materials
and Methods: Thirty-six men with type 2
diabetes who consumed metformin (age 46.08 ± 3.08 years, BMI 30.1± 2.32 kg/m2)
volunteered to participate in this study. Subjects were randomly assigned in 2
groups. In this respect, 18 subjects were in the aerobic exercise group (3 days
per week, 35 to 50 min per day, 40-55% heart rate reserve) and 18 subjects in
the control group. Fasting plasma visfatin, insulin, glucose and HbA1c
concentrations were measured
before and after 8 weeks of exercise in these diabetic patients. For analysis
of data, repeated measures ANOVA was used. Results: The findings showed that plasma visfatin level, insulin, glucose,
HbA1c, BMI, WHR and body fat percentage significantly decrease in
aerobic exercise group as compared to control group (p < 0.05). The peak rate
of oxygen consumption (vo2 peak) significantly increased in aerobic exercise
group as compared to control group (p < 0.05). Conclusion: The present study showed that decreased plasma visfatin level induced
by aerobic exercise is most likely the result of improving glycemic status in
type 2 diabetes patients treated with metformin. Background
and Objective: Visfatin is a
recently discovered adipokine. Previous studies have shown a direct
relationship between plasma visfatin levels and type 2 diabetes mellitus. The current study was conducted to
investigate the effect of aerobic exercise on
plasma level of visfatin in type 2 diabetic men treated with metformin. Materials
and Methods: Thirty-six men with type 2
diabetes who consumed metformin (age 46.08 ± 3.08 years, BMI 30.1± 2.32 kg/m2)
volunteered to participate in this study. Subjects were randomly assigned in 2
groups. In this respect, 18 subjects were in the aerobic exercise group (3 days
per week, 35 to 50 min per day, 40-55% heart rate reserve) and 18 subjects in
the control group. Fasting plasma visfatin, insulin, glucose and HbA1c
concentrations were measured
before and after 8 weeks of exercise in these diabetic patients. For analysis
of data, repeated measures ANOVA was used. Results: The findings showed that plasma visfatin level, insulin, glucose,
HbA1c, BMI, WHR and body fat percentage significantly decrease in
aerobic exercise group as compared to control group (p < 0.05). The peak rate
of oxygen consumption (vo2 peak) significantly increased in aerobic exercise
group as compared to control group (p < 0.05). Conclusion: The present study showed that decreased plasma visfatin level induced
by aerobic exercise is most likely the result of improving glycemic status in
type 2 diabetes patients treated with metformin. https://daneshvarmed.shahed.ac.ir/article_1544_3a16a38f939c394cdfab3be8f9a43825.pdfShahed UniversityDaneshvar Medicine2716-972320420121022A comparison between the analgesic effect of tragacanth gum, diclofenac and morphine in mice using writhing and hot-plate analgesic testsA comparison between the analgesic effect of tragacanth gum, diclofenac and morphine in mice using writhing and hot-plate analgesic tests25341545FALeilaKeihaniMohammad EbrahimRezvaniMohammad HossainDashti- RahmatabadiJournal Article20200926 Background and Objective: Some of medicinal plants have been used for pain
reliving in Iarnian ancient medicine. Astragalus
gummifer (AG) is one of them and its gum (tragacanth gum) were used
for several health purposes. The present study was conducted to evaluate the
analgesic effects of this gum in mice. Materials and Methods: In this study, the analgesic
effect of tragacanth gum was determined using
hot-plate and writhing tests. Mice were injected with tragacanth gum
at doses of 125, 250 or 500 µg/kg i.p. as treatment
groups. Morphine at doses of 2, 4 or 8 µg/kg i.p., and diclofenac at doses of 10,
20 or 30 µg/kg i.p. were used as control groups. Results: In writhing
test, gum tragacanth at different doses (125, 250, and 500 µg/kg ) significantly reduced the
number of writhings in mice as compared to control group (p < 0.05). In hot-plate
test, maximum possible effect of tragacanth gum significantly increased only
after 15 minutes but not in other time periods. In two models of pain assesment,
both morphine sulfate and diclofenac sodium had also pain relieving potential. Coclusion: The present study indicated that tragacanth gum elicits prominent
analgesic effects in an experimental model of acute and chronic pain.
Additionally, data obtained in this study indicated the presence of some
constituents with pain releiving properties that confirms the traditional use
of the gum for pain relieving purposes. Background and Objective: Some of medicinal plants have been used for pain
reliving in Iarnian ancient medicine. Astragalus
gummifer (AG) is one of them and its gum (tragacanth gum) were used
for several health purposes. The present study was conducted to evaluate the
analgesic effects of this gum in mice. Materials and Methods: In this study, the analgesic
effect of tragacanth gum was determined using
hot-plate and writhing tests. Mice were injected with tragacanth gum
at doses of 125, 250 or 500 µg/kg i.p. as treatment
groups. Morphine at doses of 2, 4 or 8 µg/kg i.p., and diclofenac at doses of 10,
20 or 30 µg/kg i.p. were used as control groups. Results: In writhing
test, gum tragacanth at different doses (125, 250, and 500 µg/kg ) significantly reduced the
number of writhings in mice as compared to control group (p < 0.05). In hot-plate
test, maximum possible effect of tragacanth gum significantly increased only
after 15 minutes but not in other time periods. In two models of pain assesment,
both morphine sulfate and diclofenac sodium had also pain relieving potential. Coclusion: The present study indicated that tragacanth gum elicits prominent
analgesic effects in an experimental model of acute and chronic pain.
Additionally, data obtained in this study indicated the presence of some
constituents with pain releiving properties that confirms the traditional use
of the gum for pain relieving purposes. https://daneshvarmed.shahed.ac.ir/article_1545_7ed0548fd30dc7817d0cca57d0bb889a.pdfShahed UniversityDaneshvar Medicine2716-972320420121022Comparison of clinical response to Zataria multiflora vaginal cream and boric acid in patients with recurrent vulvovaginal candidiasisComparison of clinical response to Zataria multiflora vaginal cream and boric acid in patients with recurrent vulvovaginal candidiasis35421546FAMaryamRabiei0000-0002-7487-7863HosseinAkbariMohsenNaseriRezaBekhradiMaryamNikzadFarahnazTorkestaniJournal Article20200926 Background and Objective: Since long-term therapy of recurrent
vulvovaginal candidiasis patients with azol is accompanied with drug resistance
and systemic toxicity, thus, researches have returned to non-azole drugs. This
research compared clinical response of these patients to boric acid and
leukorex (Zataria multiflora). Materials and Methods: This study was performed as a blind clinical
trial in control with positive cases (parallel). Patients with recurrent
vulvovaginal candidiasis that had a positive culture without any predisposing
factors were enrolled in this survey. Vaginal cream of Zataria multiflora
1% and boric acid 3% were given blindly. Signs and symptoms on first visit, and
1 and 6 months after starting treatment was analyzed using chi square, Mann-Whitney
and t tests. Results: In boric acid group, the score of severity signs initially was 9±3.3
that got to 3.48±3.8 and 3.33±5.1 in first and second periods of therapy,
respectively. In Zataria multiflora group, the score of severity signs initially
was 8.21±3.6 that got to 2.52±2.46 and 3.36±3.7 in first and second periods of
therapy, respectively. The reduced scores of two groups were significant (p < /001).
The final cure rate was 74/2% and 64/5% in boric acid and Zataria multiflora
groups, respectively that there was not a significant difference between the two
groups. Conclusion: Zataria multiflora is considers as an
alternative drug in treatment of patients with recurrent vulvovaginal
candidiasis. Background and Objective: Since long-term therapy of recurrent
vulvovaginal candidiasis patients with azol is accompanied with drug resistance
and systemic toxicity, thus, researches have returned to non-azole drugs. This
research compared clinical response of these patients to boric acid and
leukorex (Zataria multiflora). Materials and Methods: This study was performed as a blind clinical
trial in control with positive cases (parallel). Patients with recurrent
vulvovaginal candidiasis that had a positive culture without any predisposing
factors were enrolled in this survey. Vaginal cream of Zataria multiflora
1% and boric acid 3% were given blindly. Signs and symptoms on first visit, and
1 and 6 months after starting treatment was analyzed using chi square, Mann-Whitney
and t tests. Results: In boric acid group, the score of severity signs initially was 9±3.3
that got to 3.48±3.8 and 3.33±5.1 in first and second periods of therapy,
respectively. In Zataria multiflora group, the score of severity signs initially
was 8.21±3.6 that got to 2.52±2.46 and 3.36±3.7 in first and second periods of
therapy, respectively. The reduced scores of two groups were significant (p < /001).
The final cure rate was 74/2% and 64/5% in boric acid and Zataria multiflora
groups, respectively that there was not a significant difference between the two
groups. Conclusion: Zataria multiflora is considers as an
alternative drug in treatment of patients with recurrent vulvovaginal
candidiasis. https://daneshvarmed.shahed.ac.ir/article_1546_1af15ae5429f7c15724f12b1139038b7.pdfShahed UniversityDaneshvar Medicine2716-972320420121022Evaluation of nutritional behavior of elderly people about prevention of gastric ulcers in ShirazEvaluation of nutritional behavior of elderly people about prevention of gastric ulcers in Shiraz43501547FAAmirAlmasi Hashyani0000-0003-4434-561XMosaSalehiBaharTorke-JokarMohsenShamsiJournal Article20200926 Background and Objective: The aged population is
growing in Iran. Mal-nutrition is a very
common disorder in elderly people, which is not diagnosed in most cases and,
therefore, remains untreated. Aim of this study was to evaluate the nutritional
behavior of elderly about prevention of gastric ulcers in Shiraz. Materials
and Methods: This is a cross-sectional and
analytical study that carried out on 270 elders (184
women and 86 men) in Shiraz. Inclusion criteria were ages
between 60-70 years and without mental or physical illness. Data collection
included questionnaire consisting of demographic information, survey knowledge
questions and checklist for assessment and nutritional practice. Finally, for data analysis, the
relationship between nutritional status and demographic
factors was determined using logistic
regression. Results: The results indicated that in terms of physical health, about 48%
of the women and 41% of the elder men have disease and treated. Prevalence of
various diseases such as hypertension, arthritis, osteoporosis and diabetes were
more in women than men. Logistic regression analysis showed that the proper
relationship between demographic factors and level of education (OR = 0.31, CI=0.68-1.8), high income (OR =2.7 CI=
1.6-4.3) and higher age (OR= 1.9 CI= 1.3-3.8) was statistically significant. Conclusion: Considering the
possibility of appropriate intervention regarding these factors affecting health
of elderly, nutritional behavior modification programs are important for elderly
and provision of educational program is proposed. Background and Objective: The aged population is
growing in Iran. Mal-nutrition is a very
common disorder in elderly people, which is not diagnosed in most cases and,
therefore, remains untreated. Aim of this study was to evaluate the nutritional
behavior of elderly about prevention of gastric ulcers in Shiraz. Materials
and Methods: This is a cross-sectional and
analytical study that carried out on 270 elders (184
women and 86 men) in Shiraz. Inclusion criteria were ages
between 60-70 years and without mental or physical illness. Data collection
included questionnaire consisting of demographic information, survey knowledge
questions and checklist for assessment and nutritional practice. Finally, for data analysis, the
relationship between nutritional status and demographic
factors was determined using logistic
regression. Results: The results indicated that in terms of physical health, about 48%
of the women and 41% of the elder men have disease and treated. Prevalence of
various diseases such as hypertension, arthritis, osteoporosis and diabetes were
more in women than men. Logistic regression analysis showed that the proper
relationship between demographic factors and level of education (OR = 0.31, CI=0.68-1.8), high income (OR =2.7 CI=
1.6-4.3) and higher age (OR= 1.9 CI= 1.3-3.8) was statistically significant. Conclusion: Considering the
possibility of appropriate intervention regarding these factors affecting health
of elderly, nutritional behavior modification programs are important for elderly
and provision of educational program is proposed. https://daneshvarmed.shahed.ac.ir/article_1547_6ff49ed0156d402b3fdb59c559db7c62.pdfShahed UniversityDaneshvar Medicine2716-972320420121022The effect of fatigue and clinical course on depression, anxiety, stress, quality of life and employment status in patients with multiple sclerosisThe effect of fatigue and clinical course on depression, anxiety, stress, quality of life and employment status in patients with multiple sclerosis51621548FAGhasemSalehpoorSajjadRezaeiIrajSalehiJournal Article20200926 Background and Objective: Fatigue is a common
symptom in multiple sclerosis (MS) and
most MS patients are of two types relapsing-remitting (RRMS) and secondary progressive (SPMS). Fatigue with regard to feeling of weakness,
lack of energy and clinical
course due to the establishment of a
variable prognosis can influence psychological symptoms, functional ability and
employment status of patients. Thus, the aim of the present study was to evaluate the effect of fatigue and
clinical course on psychological
symptoms, physical and psychological dimensions,
and employment status.
Materials
and Methods: In this retrospective cross-sectional study, 152 patients were sampled by consecutive method. All patients were
evaluated using fatigue severity scale (FSS), depression, anxiety, and stress scale (DASS-21)
and short form
health survey questionnaire
(SF-36). Data were analyzed using multivariate variance analysis (MANOVA)
and Fisher exact test. Results:
Mean
of psychological symptoms and physical and psychological
dimensions scores in fatigued and SPMS patients
was worse than non-fatigued and RRMS groups. Also, un-employment
was reported with
higher frequency in fatigued patients. In this regard, no significant finding
was observed between RRMS and SPMS. In
addition, the difference between both groups of fatigued
and non-fatigued, RRMS and SPMS patients
was significant regarding the variables
depression, anxiety, stress, and physical
and psychological dimensions (p < 0.05). Conclusion:
This
study explained the impact of fatigue and clinical course on psychological symptoms, physical and psychological
aspects of life and employment status of MS
patients. However, it seems that the influence of some variables on each other in a bidirectional
relationship is also explainable. Clinical implications have been discussed
in this report. Background and Objective: Fatigue is a common
symptom in multiple sclerosis (MS) and
most MS patients are of two types relapsing-remitting (RRMS) and secondary progressive (SPMS). Fatigue with regard to feeling of weakness,
lack of energy and clinical
course due to the establishment of a
variable prognosis can influence psychological symptoms, functional ability and
employment status of patients. Thus, the aim of the present study was to evaluate the effect of fatigue and
clinical course on psychological
symptoms, physical and psychological dimensions,
and employment status.
Materials
and Methods: In this retrospective cross-sectional study, 152 patients were sampled by consecutive method. All patients were
evaluated using fatigue severity scale (FSS), depression, anxiety, and stress scale (DASS-21)
and short form
health survey questionnaire
(SF-36). Data were analyzed using multivariate variance analysis (MANOVA)
and Fisher exact test. Results:
Mean
of psychological symptoms and physical and psychological
dimensions scores in fatigued and SPMS patients
was worse than non-fatigued and RRMS groups. Also, un-employment
was reported with
higher frequency in fatigued patients. In this regard, no significant finding
was observed between RRMS and SPMS. In
addition, the difference between both groups of fatigued
and non-fatigued, RRMS and SPMS patients
was significant regarding the variables
depression, anxiety, stress, and physical
and psychological dimensions (p < 0.05). Conclusion:
This
study explained the impact of fatigue and clinical course on psychological symptoms, physical and psychological
aspects of life and employment status of MS
patients. However, it seems that the influence of some variables on each other in a bidirectional
relationship is also explainable. Clinical implications have been discussed
in this report. https://daneshvarmed.shahed.ac.ir/article_1548_d69e11f85837c09490284955a5bb02e6.pdfShahed UniversityDaneshvar Medicine2716-972320420121022Interactive effect of endurance training and curcumin supplementation on some indices of liver damage in rats exposed to heavy metal leadInteractive effect of endurance training and curcumin supplementation on some indices of liver damage in rats exposed to heavy metal lead63701549FAParvinFarzanegi0000-0003-2128-3068MasoumehHabibian0000-0003-1028-1726MohammadrezaSalehiJournal Article20200926 Background and Objective: Lead can cause liver damage in which
oxidative stress is involved. Exercise and use of anti-oxidative substances such as anti-oxidative curcumin may stop < /span>
the production of free radicals. The purpose of the present study was
to investigate the protective effect of endurance
training and curcumin against lead toxic effect on hepatic tissue in male rats. Materials and
Methods: In this experimental study, 60
male Wistar rats were randomly
divided into 6 groups, control , sham, lead, exercise + lead, curcumin+lead and exercise+lead+curcumin (n=10 in each group). The exercise training
consisted of 25-64 min of running on an ungraded
treadmill at a speed of
15-22 m/min for 8 weeks. Curcumin (30 mg/kg) and lead (20 mg/kg of lead acetate) were administered for 8 weeks, 3 days/week, intraperitoneally. Serum ALT, AST and ALP were measured by colorimetric method. Results: The results showed that 8 weeks of lead
exposure causes a significant increase of AST and ALT
in the lead group < /font>
as compared to control group < /font> (p =0.002,
p = 0.007, respectively). Endurance training and curcumin consumption significantly decreased AST and
ALT(p =0.041 and p =0.009, respectively). After endurance training and curcumin consumption, ALP non-significantly decreased
(p =0.692). Conclusion: Regular exercise and curcumin supplement may
inhibit liver damage induced
by lead. Background and Objective: Lead can cause liver damage in which
oxidative stress is involved. Exercise and use of anti-oxidative substances such as anti-oxidative curcumin may stop < /span>
the production of free radicals. The purpose of the present study was
to investigate the protective effect of endurance
training and curcumin against lead toxic effect on hepatic tissue in male rats. Materials and
Methods: In this experimental study, 60
male Wistar rats were randomly
divided into 6 groups, control , sham, lead, exercise + lead, curcumin+lead and exercise+lead+curcumin (n=10 in each group). The exercise training
consisted of 25-64 min of running on an ungraded
treadmill at a speed of
15-22 m/min for 8 weeks. Curcumin (30 mg/kg) and lead (20 mg/kg of lead acetate) were administered for 8 weeks, 3 days/week, intraperitoneally. Serum ALT, AST and ALP were measured by colorimetric method. Results: The results showed that 8 weeks of lead
exposure causes a significant increase of AST and ALT
in the lead group < /font>
as compared to control group < /font> (p =0.002,
p = 0.007, respectively). Endurance training and curcumin consumption significantly decreased AST and
ALT(p =0.041 and p =0.009, respectively). After endurance training and curcumin consumption, ALP non-significantly decreased
(p =0.692). Conclusion: Regular exercise and curcumin supplement may
inhibit liver damage induced
by lead. https://daneshvarmed.shahed.ac.ir/article_1549_2ff567edce0bbca7fc7251eb8f98633a.pdfShahed UniversityDaneshvar Medicine2716-972320420121022Effects of sleep deprivation on endurance performance and hormonal responses to endurance exerciseEffects of sleep deprivation on endurance performance and hormonal responses to endurance exercise71781550FAHamidAraziAhmadGhiasiKakoHosseiniKhaledPirikordJournal Article20200926 Background and
Objective: Sleep deprivation affects
physiological and psychological functioning and probably increases the body's energy
demand. It seems that sleep deprivation can
have a negative effect
on athletes' performance and affect
the body's hormones secretion. This study investigated the effect of 24-hour
sleep deprivation on endurance
performance and hormonal responses to endurance
exercise. Materials
and Methods: Twenty young men with
a history of
resistance training were divided into experimental and control groups (double blind and randomly). In two separate days, once
after a normal
circadian sleep and again after 24 hours of
sleep deprivation, endurance performance
of subjects was assessed using the Bruce
test. Immediately after the Bruce
test, blood samples were collected
and level of cortisol and testosterone with chemiluminescence method and level of
epinephrine and norepinephrine
with ELISA method were measured. In order to analyze data, the
dependent and independent t-tests were used respectively to examine within groups and
between groups changes
of variables. Results: The
maximal oxygen consumption significantly decreased and cortisol level increased
in the experimental group. Post-test cortisol level in experimental group was
significantly higher than control group, but regarding other variables, there
were not a significant difference between the two groups. Conclusion: Our study indicated that 24-hour sleep deprivation can have
negative effects on endurance performance and increases cortisol response to
endurance exercise, but it does not change testosterone, epinephrine and
norepinephrine response to endurance exercise. Background and
Objective: Sleep deprivation affects
physiological and psychological functioning and probably increases the body's energy
demand. It seems that sleep deprivation can
have a negative effect
on athletes' performance and affect
the body's hormones secretion. This study investigated the effect of 24-hour
sleep deprivation on endurance
performance and hormonal responses to endurance
exercise. Materials
and Methods: Twenty young men with
a history of
resistance training were divided into experimental and control groups (double blind and randomly). In two separate days, once
after a normal
circadian sleep and again after 24 hours of
sleep deprivation, endurance performance
of subjects was assessed using the Bruce
test. Immediately after the Bruce
test, blood samples were collected
and level of cortisol and testosterone with chemiluminescence method and level of
epinephrine and norepinephrine
with ELISA method were measured. In order to analyze data, the
dependent and independent t-tests were used respectively to examine within groups and
between groups changes
of variables. Results: The
maximal oxygen consumption significantly decreased and cortisol level increased
in the experimental group. Post-test cortisol level in experimental group was
significantly higher than control group, but regarding other variables, there
were not a significant difference between the two groups. Conclusion: Our study indicated that 24-hour sleep deprivation can have
negative effects on endurance performance and increases cortisol response to
endurance exercise, but it does not change testosterone, epinephrine and
norepinephrine response to endurance exercise. https://daneshvarmed.shahed.ac.ir/article_1550_fec3f065220db26293a240d1f00a762a.pdf