Shahed University Daneshvar Medicine 2716-9723 31 6 2024 03 04 The effect of aerobic training with royal jelly on the expression of BCL-2, Bax and Bax / BCL2 ratio in pancreatic tissue of obese rats The effect of aerobic training with royal jelly on the expression of BCL-2, Bax and Bax / BCL2 ratio in pancreatic tissue of obese rats 26 36 4379 10.22070/daneshmed.2024.18375.1414 FA Saqqa Farajtabar Behrestaq Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran. 0000-0003-1234-0187 Mahbobeh Khonakdar Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran. 0009-0000-4878-536x Amir Taghipour Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran. 0000-0003-3482-2777 Babisan Askari Department of Physical Education and Sport Sciences, Qaemshahr Branch, Islamic Azad University, Qaemshahr, Iran. 0000-0002-9411-8549 Journal Article 2023 10 26 Background and Objective: Obesity is considered as a global disease. The purpose of this study was to evaluate the effect of aerobic exercise with royal jelly on the expression of BCL-2, Bax and the ratio of BCL2/Bax in the pancreatic tissue of obese rats. Materials and Methods: In this research, 40 5-week-old male Wistar rats were randomly divided into two groups of normal diet (ND) and high-fat diet (HFD). Rats in the ND group were fed a standard diet (23% protein, 65% carbohydrates, and 12% fat) and the HFD group were fed a high-fat diet (17% protein, 43% carbohydrates, and 40% fat) for eight weeks. Then, the rats were divided into 5 groups: normal diet, high-fat diet, high-fat-exercise (HFDT), high-fat-supplemented (HFDRj) and high-fat-exercise-supplemented (HFDTRj) groups. The training group performed incremental aerobic training for 8 weeks and 5 days per week. Also, the supplement groups were daily given 100 mg of royal jelly mixed in distilled water. Results: The results showed that induction of obesity through the consumption of high-fat foods increases BCL-2 gene expression and significantly decreases BAX gene expression in the high-fat group compared to the control group. Also, endurance exercises and gel supplementation decreased BCL-2 gene expression and increased BAX gene expression in the experimental groups compared to the high-fat group and these changes were more noticeable in the combined group. Conclusion: It is possible that aerobic training along with the use of royal jelly can be an effective strategy in improving the condition of obesity through the process of apoptosis. Background and Objective: Obesity is considered as a global disease. The purpose of this study was to evaluate the effect of aerobic exercise with royal jelly on the expression of BCL-2, Bax and the ratio of BCL2/Bax in the pancreatic tissue of obese rats. Materials and Methods: In this research, 40 5-week-old male Wistar rats were randomly divided into two groups of normal diet (ND) and high-fat diet (HFD). Rats in the ND group were fed a standard diet (23% protein, 65% carbohydrates, and 12% fat) and the HFD group were fed a high-fat diet (17% protein, 43% carbohydrates, and 40% fat) for eight weeks. Then, the rats were divided into 5 groups: normal diet, high-fat diet, high-fat-exercise (HFDT), high-fat-supplemented (HFDRj) and high-fat-exercise-supplemented (HFDTRj) groups. The training group performed incremental aerobic training for 8 weeks and 5 days per week. Also, the supplement groups were daily given 100 mg of royal jelly mixed in distilled water. Results: The results showed that induction of obesity through the consumption of high-fat foods increases BCL-2 gene expression and significantly decreases BAX gene expression in the high-fat group compared to the control group. Also, endurance exercises and gel supplementation decreased BCL-2 gene expression and increased BAX gene expression in the experimental groups compared to the high-fat group and these changes were more noticeable in the combined group. Conclusion: It is possible that aerobic training along with the use of royal jelly can be an effective strategy in improving the condition of obesity through the process of apoptosis.

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