Shahed University Daneshvar Medicine 2716-9723 20 5 2012 12 21 The effect of aerobic exercise on plasma visfatin levels in men with type 2diabetes treated with metformin The effect of aerobic exercise on plasma visfatin levels in men with type 2diabetes treated with metformin 17 24 3087 FA Mohammad Azimi Faculty of Physical Education and Sport Science, University of Shahid Bahonar Kerman, Kerman, Iran. Hamid Marefati Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, Shahid Bahonar University of Kerman, Kerman, Iran. Gholamreza Yousefzadeh Physiology Research Center, Kerman University of Medical Sciences, Kerman, Iran. Majid Mohajeri Department of Endocrinology and Metabolism, University of Medical Sciences Kerman, Kerman, Iran Journal Article 2012 07 28 <strong>Background and Objective</strong>: Visfatin is a recently discovered adipokine. Previous studies have shown a direct relationship between plasma visfatin levels and type 2 diabetes mellitus. The current study was conducted to investigate the effect of aerobic exercise on plasma level of visfatin in type 2 diabetic men treated with metformin. <strong> </strong><strong>Materials and Methods</strong>: Thirty-six men with type 2 diabetes who consumed metformin (age 46.08 ± 3.08 years, BMI 30.1± 2.32 kg/m<strong>²</strong>) volunteered to participate in this study. Subjects were randomly assigned in 2 groups. In this respect, 18 subjects were in the aerobic exercise group (3 days per week, 35 to 50 min per day, 40-55% heart rate reserve) and 18 subjects in the control group. Fasting plasma visfatin, insulin, glucose and HbA_1c concentrations were measured before and after 8 weeks of exercise in these diabetic patients. For analysis of data, repeated measures ANOVA was used. <strong> </strong><strong>Results</strong>: The findings showed that plasma visfatin level, insulin, glucose, HbA_1c, BMI, WHR and body fat percentage significantly decrease in aerobic exercise group as compared to control group (p<0.05). The peak rate ​​of oxygen consumption (vo2 peak) significantly increased in aerobic exercise group as compared to control group (p<0.05). <strong> </strong><strong>Conclusion</strong>: The present study showed that decreased plasma visfatin level induced by aerobic exercise is most likely the result of improving glycemic status in type 2 diabetes patients treated with metformin. <strong>Background and Objective</strong>: Visfatin is a recently discovered adipokine. Previous studies have shown a direct relationship between plasma visfatin levels and type 2 diabetes mellitus. The current study was conducted to investigate the effect of aerobic exercise on plasma level of visfatin in type 2 diabetic men treated with metformin. <strong> </strong><strong>Materials and Methods</strong>: Thirty-six men with type 2 diabetes who consumed metformin (age 46.08 ± 3.08 years, BMI 30.1± 2.32 kg/m<strong>²</strong>) volunteered to participate in this study. Subjects were randomly assigned in 2 groups. In this respect, 18 subjects were in the aerobic exercise group (3 days per week, 35 to 50 min per day, 40-55% heart rate reserve) and 18 subjects in the control group. Fasting plasma visfatin, insulin, glucose and HbA_1c concentrations were measured before and after 8 weeks of exercise in these diabetic patients. For analysis of data, repeated measures ANOVA was used. <strong> </strong><strong>Results</strong>: The findings showed that plasma visfatin level, insulin, glucose, HbA_1c, BMI, WHR and body fat percentage significantly decrease in aerobic exercise group as compared to control group (p<0.05). The peak rate ​​of oxygen consumption (vo2 peak) significantly increased in aerobic exercise group as compared to control group (p<0.05). <strong> </strong><strong>Conclusion</strong>: The present study showed that decreased plasma visfatin level induced by aerobic exercise is most likely the result of improving glycemic status in type 2 diabetes patients treated with metformin. https://daneshvarmed.shahed.ac.ir/article_3087_72daaec946b3a47c81683b0a508ad97b.pdf