Volume 20, Issue 102 (1-2013)                   Daneshvar Medicine 2013, 20(102): 35-42 | Back to browse issues page

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rabiei M, akbari H, naseri M, bekhradi R, nikzad M, torkestani F. Comparison of clinical response to Zataria multiflora vaginal cream and boric acid in patients with recurrent vulvovaginal candidiasis. Daneshvar Medicine. 2013; 20 (102) :35-42
URL: http://daneshvarmed.shahed.ac.ir/article-1-627-en.html
shahed university
Abstract:   (8065 Views)

Background and Objective: Since long-term therapy of recurrent vulvovaginal candidiasis patients with azol is accompanied with drug resistance and systemic toxicity, thus, researches have returned to non-azole drugs. This research compared clinical response of these patients to boric acid and leukorex (Zataria multiflora).


Materials and Methods: This study was performed as a blind clinical trial in control with positive cases (parallel). Patients with recurrent vulvovaginal candidiasis that had a positive culture without any predisposing factors were enrolled in this survey. Vaginal cream of Zataria multiflora 1% and boric acid 3% were given blindly. Signs and symptoms on first visit, and 1 and 6 months after starting treatment was analyzed using chi square, Mann-Whitney and t tests.


Results: In boric acid group, the score of severity signs initially was 9±3.3 that got to 3.48±3.8 and 3.33±5.1 in first and second periods of therapy, respectively. In Zataria multiflora group, the score of severity signs initially was 8.21±3.6 that got to 2.52±2.46 and 3.36±3.7 in first and second periods of therapy, respectively. The reduced scores of two groups were significant (pZataria multiflora groups, respectively that there was not a significant difference between the two groups.


Conclusion: Zataria multiflora is considers as an alternative drug in treatment of patients with recurrent vulvovaginal candidiasis.

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Type of Study: Research |

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