Volume 20, Issue 102 (1-2013)                   Daneshvar Medicine 2013, 20(102): 17-24 | Back to browse issues page

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azimi S M, marefati H, yousefzadeh G, mohajeri M. The effect of aerobic exercise on plasma visfatin levels in men with type 2diabetes treated with metformin. Daneshvar Medicine. 2013; 20 (102) :17-24
URL: http://daneshvarmed.shahed.ac.ir/article-1-625-en.html
Abstract:   (9796 Views)

Background and Objective: Visfatin is a recently discovered adipokine. Previous studies have shown a direct relationship between plasma visfatin levels and type 2 diabetes mellitus. The current study was conducted to investigate the effect of aerobic exercise on plasma level of visfatin in type 2 diabetic men treated with metformin.


Materials and Methods: Thirty-six men with type 2 diabetes who consumed metformin (age 46.08 ± 3.08 years, BMI 30.1± 2.32 kg/m2) volunteered to participate in this study. Subjects were randomly assigned in 2 groups. In this respect, 18 subjects were in the aerobic exercise group (3 days per week, 35 to 50 min per day, 40-55% heart rate reserve) and 18 subjects in the control group. Fasting plasma visfatin, insulin, glucose and HbA1c concentrations were measured before and after 8 weeks of exercise in these diabetic patients. For analysis of data, repeated measures ANOVA was used.


Results: The findings showed that plasma visfatin level, insulin, glucose, HbA1c, BMI, WHR and body fat percentage significantly decrease in aerobic exercise group as compared to control group (p<0.05). The peak rate ​​of oxygen consumption (vo2 peak) significantly increased in aerobic exercise group as compared to control group (p<0.05).


Conclusion: The present study showed that decreased plasma visfatin level induced by aerobic exercise is most likely the result of improving glycemic status in type 2 diabetes patients treated with metformin.

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