Volume 16, Issue 1 (7-2009)                   DMed 2009, 16(1): 55-62 | Back to browse issues page

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beiglarian A, hajizadeh E, kazemnejad A, zali M. Postoperative Survival Prediction in Patients with Gastric Cancer. DMed. 2009; 16 (1) :55-62
URL: http://daneshvarmed.shahed.ac.ir/article-1-60-en.html
, hajizadeh@modares.ac.ir
Abstract:   (42525 Views)

  Background and Objective: Stomach cancer is the second most common cancer and is known as the second cause of death due to cancers, worldwide and in Iran, adenocarcinoma is the most fatal cancer and Those who have this kind of cancer, have a lower lifetime In comparison with others.: In this research, survival of patients with gastric adenocarcinomas who Have been operated on in Taleghani hospital was studied.

  Materials and Methods: 455 cancer patients with documented gastric adenocarcinomas pathology who had operation at the Taleghani Hospital in Tehran between 2002 and 2007were analyzed as a historical prospective study. The patients' survival after surgery and its relationship with age , gender, and body mass index, exposure to Chemical Weapons, familial history, tumor grade, high-risk habits(overuse of salt or smoking), disease histology (Lauren Classification), histology type, tumor stage, and symptoms at diagnosis and tumor size variables were assessed. Kaplan Meier method, Cox Proportional hazards model, Breslow and Tarone-Ware estimator were used for analysis of dataset.

  Results: 71.6 percent of patients were man and others (28.4%) were women. The mean age Of men was 59.39 years and that of women Was 56.22 years. The mean and median of survival time Were 32.56 and 28.3 month, respectively and 1- through 5 years survival rate was 0.78, 0.53, 0.40, 0.32 and 0.15 respectively. The Cox proportional hazards model showed that age at diagnosis, familial history and tumor size had a significant relationship with survival of the patients (p=0.023, p=0.045 and p=0.032 respectively).

  Conclusion: Survival rate of gastric cancer patients is low and one of the serious reasons for this seems to be delayed diagnosis. Therefore, utilization of public education about diagnosis and early warning signs of the disease and performing periodic examinations is inevitable.


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