Volume 16, Issue 1 (7-2009)                   DMed 2009, 16(1): 23-28 | Back to browse issues page

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yazdizadeh V, kazemnejad A, modares gilani M. The Effect of Fluoxetin on Hot Flashes in Menopaused Women. DMed. 2009; 16 (1) :23-28
URL: http://daneshvarmed.shahed.ac.ir/article-1-56-en.html
, yazdizadeh2008@yahoo.com
Abstract:   (24120 Views)

  Background: Hot flash is a common problem in climactric (time course around menopause)and menopausal period. The most effective treatment of it is HRT but There is a serious need for alternative therapies for hot flashes, as hormone replacement therapy (HRT) is associated with increased rates of breast cancer and heart disease.

  Materials and Methods: This trial used a randomized, two-stage(4 weeks per stage), cross over methodology to study the efficacy of fluoxetin (20 mg/d) for treating hot flashes in menopausal women (who atleast had 14 hot flash attacks per week.) in first period, First group received 4 weeks of therapy with fluoxetine versus second group receiving placebo.during the next stage of treatment, patients were crossed over between two groups . The patients received no drug in the one week period interval between the two periods of study.(wash out).T-test, chi square, mann whitney, pair t-test, wilcocxon and fisher, tests were used for analysing data in spss software.

  Results: Eighty randomized women began protocol therapy. By the end of the first treatment period, hot flash frequency decreased 55% in the fluoxetin arm versus 28% in the placebo arm. Cross over analyzing demonstrated a significantly greater marked improvement in hot flash severity with fluoxetin than with placebo (p=0/00).

  Conclusion: Both Fluoxetin and placebo are effective in improving of hot flashs but fluoxetin is significantly more effective. So fluoxetine is a realistic althernative theray for women who do not wish to receive hormones for fear of cancer or other reasons.


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