Volume 16, Number 82 (9-2009)                   daneshvarmed 2009, 16(82): 27-36 | Back to browse issues page


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amini H, heshmati M, jalali M. The Study of the Effect of Deprenyl on Gliosis after Spinal Cord Compression in Adult Rat. daneshvarmed. 2009; 16 (82) :27-36
URL: http://daneshvarmed.shahed.ac.ir/article-1-47-en.html

Medical Student
Abstract:   (6150 Views)

  Background and Objective: To study the effect of deprenyl on neuroprotective or survival on motoneuron and on gliosis reaction.

  Materials and Methods: Sprague Dawley rats (250-300 gr) of Razi institution were used to determine the effect of deprenyl (2.50 mg/kg ) on neuroprotective or survival on motoneuron and on gliosis reaction through morphometry and immunohistochemistry methods.

  Results: The results are divided into two parts:1- the result of morphometry for motoneuron.2- Astrocyte and oligodendrocyte count and their percentage. After spinal cord compression, motoneuron in ventral horn decreased with cavitation. While,the changes in study group (deprenyl ) is less than control group( normal saline) one of the groups that had taken Deprenyl for 4 weeks revealed less changes so, after 4 weeks, the neuroprotective effects of Deprenyl increased (P≤ 0.05). In addition, Deprenyl had also decreased the gliosis reaction .It was even more effective after 4 weeks (P≤ 0.05).

  Conclusion: For the first time, Deprenyl effect was studied in gliosis reaction. It seems that it decreased the number and percentage of astrocyte and became more effective after 4 weeks.By the way it needs more research to find the effect and mechanism of deprenyl in different dosage.

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Type of Study: Research |

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