Volume 19, Issue 96 (1-2012)                   Daneshvar Medicine 2012, 19(96): 57-64 | Back to browse issues page

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Roghani M, Baluchnejadmojarad T. Dose-dependent effect of thymoquinone on markers of oxidative stress in renal tissue of diabetic rats. Daneshvar Medicine. 2012; 19 (96) :57-64
URL: http://daneshvarmed.shahed.ac.ir/article-1-447-en.html
Department of Physiology, School of Medicine, Shahed University and Medicinal Plant Research Center, Tehran, Iran
Abstract:   (8672 Views)

Background and Objective: Due to important role of enhanced oxidative stress in development of renal disorder in diabetes and with regard to antidiabetic and antioxidant effect of thymoquinone, this study was conducted to evaluate the effect of its administration on renal tissue level of some markers of oxidative stress in diabetic rats.


Materials and Methods: In this experimental study, Wistar rats were divided into 5 groups, i.e. control, high dose thymoquinone-treated control (20 mg/kg), diabetic, and thymoquinone-treated diabetic groups (10 and 20 mg/kg). After 4 weeks, tissue level of malondialdehyde and nitrite and activity of superoxide dismutase (SOD) in kidney tissue were measured.


Results: Diabetic rats showed a significant increase in tissue level of malondialdehyde (p<0.01) and nitrite (p<0.05) and a significant reduction in SOD activity (p<0.05) and thymoquinone treatment at a high dose significantly reduced only levels of MDA and nitrite (p<0.05) and SOD activity in treated-diabetic groups was non-significantly higher as compared to diabetics.


Conclusion: Chronic treatment with thymoquinone dose-dependently could attenuate some markers of oxidative stress in renal tissue from diabetic rats.

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Type of Study: Research |

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