Volume 15, Issue 72 (1-2008)                   Daneshvar Medicine 2008, 15(72): 43-52 | Back to browse issues page

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gharakhanloo R. Distribution of Calcitonin Gene Related Peptide in Neuromuscular Junctions of Rat Skeletal Muscles after Increased Activity. Daneshvar Medicine. 2008; 15 (72) :43-52
URL: http://daneshvarmed.shahed.ac.ir/article-1-413-en.html
Assistant Professor Department of Physical Education, Faculty of Human Sciences, Tarbiat Modarres University
Abstract:   (9019 Views)

 Objective: Concerning the possible role of CGRP in NMJ, the aim of this research was to study the effect of an endurance training program on relative content of this neuropeptide in NMJ, of fast plantaris and slow Soleus muscles of female rats.

 Methods: The end plates were identified by FITCc-labled - α -bungarotoxin and relative content of CGRP of never endings were determined by Immunohistochemical and Image analysis methods. The size of NMJs was also measured.

 Results: In both muscles less than %14 of NMJs were moderately and strongly stained (sign of CGRP presence), while more than %50 of them did not have CGRP. In trained rats less than %16 NinJs showed CGRP in Soleus . There was similar trend in plantaris muscles, which was not significant. In both trained muscles, the size of NMJs was larger than control muscles.

 Conclusion: The results indicated that in contrast to cell body and axon, after endurance training, the amount of CGRP in NMJs decreased. With respect to the structural and functional roles of CGRP, these findings indicate the importance of physical activity in preventions/treatment of neuromuscular disorders.

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