Volume 15, Issue 72 (1-2008)                   Daneshvar Medicine 2008, 15(72): 27-36 | Back to browse issues page

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sajjadi س S E, Aslani A, peymani A. Formulation of Topical Cream of Glycyrrhiza glabra Extract for Treatment of Psoriasis. Daneshvar Medicine. 2008; 15 (72) :27-36
URL: http://daneshvarmed.shahed.ac.ir/article-1-411-en.html
Pharmaceutical Sciences Research Center, Isfahan University of Medical Sciences
Abstract:   (12255 Views)

 Introduction: Psoriasis is a dermal disease with chronic recurrent and variable clinical schematic. Its cause isn’t known and its clinical symptoms are consist of cell proliferation, dermatitis, irritation and non predicted periods of heal and recurrent. Systemic and topical steroids are old treatments of psoriasis, but recently fumaric acid derivatives and cytotoxic drugs are prescribed. Because of the anti-inflammatory effect of glycyrrhetinic acid and reports of the use of Glycyrrhiza glabra extract in the treatment of psoriasis, suitable topical formulations from the extract of this plant was investigated.

 Materials & Methods: After determination of glycyrrhetinic acid in the plant extract, six different semisolid formulation of plant was prepared and the physicochemical stability, drug release of various W/O bases, content uniformity, chemical content assay and drug release of all formulations were studied.

 Results: Although three of the topical formulations (No.1, 2 and 3) were physicochemically stable, the formulations of number 4 and 5 were more unstable and the last formulation (number 6) was the most unstable ones. The results of this study indicated that the release of drug is completely depend on the solvent and, when ethanol 70% were used as solvent, the profile of the releasing of the drug was optimum. However, using the buffer phosphate as solvent would change the releasing profile of the drug to a slow releasing profile type.

 Conclusion: By regarding to good results and high amounts of glycyrrhetinic acid in the rhizome of G. glabra and accessibility of the plant, this formulation is proposed as a suitable product for psoriasis treatment.

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