Volume 25, Issue 136 (9-2018)                   Daneshvar Medicine 2018, 25(136): 33-42 | Back to browse issues page

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Khaksar L, Tabatabaei Panah P S, Akbarzadeh R. بررسی پلی مورفیسم ژن TNF-α(rs1800629) در بیماران مبتلا به آلوپسیا آره آتا. Daneshvar Medicine. 2018; 25 (136) :33-42
URL: http://daneshvarmed.shahed.ac.ir/article-1-1970-en.html
Department of Biology, Islamic Azad University, East Tehran Branch, Tehran, Iran
Abstract:   (202 Views)

Background and Objective: Alopecia Areata (AA) is characterized by an autoimmune hair loss usually, but not limited to, the scalp, affecting approximately 1-2% of the general population. Although the etiology and pathogenesis of this disease is still unknown, it is known that TNFα-308G/A polymorphism can influence the development of AA. The aim of this study was to investigate TNF-α(rs1800629) in patients with Alopecia Areata.

 
Materials and Methods: This study included 30 AA patients and 15 healthy subjects. Genomic DNA was isolated using DNG plus method and DNA was amplified by PCR-RFLP to detect TNFα-308G/A polymorphism. Furthermore, association of this TNFα-308G/A with demographic factors was assessed.
 
Results: PCR-RFLP results showed that GG was the most frequent genotype in both patient and control groups (P= 0.816). GA genotype was detected in 30% and 20% of patients and controls, respectively (P= 0.477). Genotype AA was detected in 6.7% of controls.
 
Conclusion: The results of TNFα-308G/A polymorphism showed no significant difference with respect to AA disease and demographic factors (p>0.05).
 
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Type of Study: Research | Subject: ایمنولوژی

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