Volume 25, Issue 133 (3-2018)                   Daneshvar Medicine 2018, 25(133): 11-18 | Back to browse issues page

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Habibian M, Amanian A. The effect of swimming exercise on the Matrix mettaloproteinase 2 activity and tumor necrosis factor-α levels of liver tissue in Alloxan-induced diabetic rats. Daneshvar Medicine. 2018; 25 (133) :11-18
URL: http://daneshvarmed.shahed.ac.ir/article-1-1876-en.html
Department of Physical Education and Sports Sciences, Qaemshahar Branch, Islamic Azad University, Qaemshahar, Iran
Abstract:   (1045 Views)
Background and Objective: liver disease is highly prevalent in type 2 diabetes mellitus (T2DM) and exercise training is effective in preventing and treating diabetes-induced hepatic injury. Therefore, the aim of this study was to assess the effect of chronic swimming exercise on the hepatic matrix metalloproteinase 2 (MMP-2) activity and tumor necrosis factor-α (TNF-α) level of liver tissue in alloxan-induced diabetic rats.
Materials and Methods: In this study, 28 male Wistar rats were randomly divided into 4 groups (7 rats per group) of control, diabetes, exercise, and diabetes-exercise. Diabetes was induced by alloxan (90 mg/kg, i.p.). The animals exercised by swimming training at 5 min to 30 min per day, five days a week over 8 weeks. The rats were killed 48 h after the last treatments and liver MMP-2 and TNF-α level were evaluated by zymography and  ELISA methods. One-way analysis of variance was used for data analysis.
Results: Findings showed that the diabetes significantly increases MMP-2 activity and TNF-α level in animals (p˂0.05). In addition, 8 weeks swimming training were associated with a significant decrease of TNF-α level and MMP-2 activity in the liver tissue of diabetic rats (p˂0.05).
Conclusion: It seems that regular swimming training can partially prevent diabetes-induced liver injury via decreasing MMP-2 activity and TNF-α level in diabetic rats.
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Type of Study: Research | Subject: فیزیولوژی ورزش

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