Volume 25, Issue 132 (1-2018)                   Daneshvar Medicine 2018, 25(132): 21-30 | Back to browse issues page

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Goodarzi N, Zangeneh M M, Zangeneh A. The effect of ethanolic extract of Allium Saralicum R.M. Fritsch on diabetic hepatopathy in male mice . Daneshvar Medicine. 2018; 25 (132) :21-30
URL: http://daneshvarmed.shahed.ac.ir/article-1-1844-en.html
Department of Basic and Pathobiological Sciences, Faculty of Veterinary Medicine, Razi University, Kermanshah, Iran
Abstract:   (974 Views)
Background and Objective: Using medicinal plants is the oldest way to treat the different diseases. Various plants are recommended for the treatment of diabetic patients. Hepatoprotective and antidiabetic effects of the ethanolic extract of Allium Saralicum R.M. Fritsch (ASRMF) on diabetic male mice has been assessed in the present study.
 
Materials and Methods:  In this experimental study, 35 adult male mice were used. Diabetes was induced by administration of 60 mg/kg of streptozotocin intraperitoneally in 28 mice and they were divided into 5 groups of 7 mice each. The positive control group (non-treated diabetic) received normal saline and treatment groups received glibenclamide at a dose of 0.5 mg/kg and 200 and 400 μg/kg of ethanolic extract of ASRMF through gavage for 15 days. Also, one group considered as negative control (non- diabetic). On the last day, serum levels of glucose and AST (aspartate aminotransferase), ALT (alanine aminotransferase), and ALP (alkaline phosphatase) enzymes were measured. After preparation of tissue sections and staining, total volume of the liver, hepatocytes, sinusoids, portal vein, central vein, hepatic arteries and bile ducts were estimated.
 
Results:  The increased levels of blood glucose and AST and ALP enzymes were significantly decreased (P<0.05) in ethanolic ASRMF extract-treated groups as compared to the untreated diabetic. The total volume of liver, central vein, portal vein and hepatic artery significantly increased (P<0.05) after treatment with ASRMF extract as compared to the negative control group. 
 
Conclusion: Ethanolic extract of ASRMF can regulate the levels of blood glucose and AST and ALP enzymes but can not inhibit hepatic damages in streptozotocin-induced diabetic mice. 
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Type of Study: Research | Subject: روانشناسی

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