Volume 24, Issue 129 (7-2017)                   Daneshvar Medicine 2017, 24(129): 1-8 | Back to browse issues page

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MohseniMajd A, Ghazanfari T, Dilmaghanian R. Evaluation of serum and sputum level of IL-21 in Sardasht chemical victims and its relationship with long-term pulmonary complications (27 years after sulfur mustard exposure). Daneshvar Medicine. 2017; 24 (129) :1-8
URL: http://daneshvarmed.shahed.ac.ir/article-1-1753-en.html

Immunoregulation Research Center, Shahed University, Tehran, Iran
Abstract:   (704 Views)
Background and Objectives: Pulmonary complications are one of the most important long-term sulfur mustard (SM) exposure that chemical victims are suffering for years. IL-21 is one of the important cytokines contributing in chronic pulmonary inflammatory diseases. In this study, the serum and sputum levels of IL-21 and their correlations with pulmonary complications was evaluated 27 years after sulfur mustard exposure.
Materials and Methods: Final sample size was 475 (350 men and 125 women) SM exposed and 150 (100 men and 50 women from Rabat) unexposed controls. The age span of volunteers was 27-67 years.
Results: There was no significant different between exposed and control groups in serum and sputum levels of IL-21, but the serum level of IL-21 showed a significant correlation with spirometry parameter (FEV1/FVC) in SM exposed group was observed.
Conclusion: The affected serum and sputum levels of IL-21 by sulfur mustard exposure were not variable, but there was a significant negative correlation between serum level of IL-21and FEV1/FVC in SM exposed group.
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Type of Study: Research | Subject: ایمنولوژی

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