Volume 22, Issue 116 (5-2015)                   Daneshvar Medicine 2015, 22(116): 71-76 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Dose-dependent effect of hesperetin on motor asymmetry induced by intrastriatal injection of 6-hydroxydopamine in the rat. Daneshvar Medicine. 2015; 22 (116) :71-76
URL: http://daneshvarmed.shahed.ac.ir/article-1-1200-en.html
Abstract:   (3649 Views)
Background and Objective: Parkinson's disease is a rather common movement disorder in aged individuals due to degeneration of dopaminergic neurons within the substantia nigra pars compacta. Due to antioxidant, anti-inflammatory and protective effects of the flavanone hesperetin, the present study assessed dose-dependent effect of hesperetin on motor asymmetry induced by intrastriatal injection of 6-hydroxydopamine in the rat. Materials and Methods: In this experimental study, male rats (n=35) were divided into sham, lesion, and hesperetin-treated lesion groups. Model of Parkinson's disease was induced by injecting 12.5 microgram of 6-hydroxydopamine-ascorbate dissolved in saline-ascorbate solution into the left striatum. Treated lesion groups received hesperetin at doses of 5, 15, and 50 mg/kg/day p.o. one hour after surgery for 1 week. After 1 week, leftward and rightward rotational behavior induced by apomorphine was assessed. Results: In the lesion group, apomorphine caused contralateral rotational behavior (P<0.001). Administration of hesperetin only at a dose of 50 mg/kg significantly reduced the number of contralateral rotations (P<0.05) and it had not such an effect at other doses. Conclusion: Oral hesperetin treatment at a dose of 50 mg/kg reduces motor asymmetry (attenuation of rotational behavior) in an experimental model of Parkinson's disease.
Full-Text [PDF 447 kb]   (796 Downloads)    
Type of Study: Research | Subject: آموزش پزشکی

Add your comments about this article : Your username or Email:
CAPTCHA

© 2019 All Rights Reserved | Daneshvar

Designed & Developed by : Yektaweb