تاثیر هشت هفته تمرین تناوبی بر سطوح پلاسمایی پروتئین‌های سیرتوئین 1 و سیرتوئین 3 مردان سالمند غیر‌فعال

نوع مقاله : مقاله پژوهشی

نویسندگان

گروه تربیت بدنی، دانشگاه آزاد اسلامی واحد اهواز، اهواز، ایران

چکیده

مقدمه و هدف: پروتئین‌های سیرتوئین در فرآیندهای متابولیک و هموستازی بدن درگیر می‌شوند و با فشار اکسایشی ناشی از سالمندی و بیماری‌های مربوط به سن مرتبط هستند. تغییرات این پروتئین‌ها در سالمندی و تاثیر فعالیت بدنی بر آنها کمتر مورد بررسی قرار گرفته است، از این رو هدف از مطالعه حاضر، بررسی تاثیر هشت هفته تمرین تناوبی بر سطوح پلاسمایی پروتئین‌های سیرتوئین 1 و سیرتوئین 3 مردان سالمند غیر‌ فعال بود.
مواد و روش ها: در این تحقیق 20 مرد سالمند غیر فعال با دامنه سنی 70-60 سال به صورت نمونه‌گیری در‌ دسترس انتخاب و به روش تصادفی ساده به دو گروه تجربی و کنترل تقسیم شدند. جهت بررسی تاثیر سالمندی بر سطوح پلاسمایی پروتئین‌های سیرتوئین 1 و سیرتوئین 3، 10 مرد جوان غیر‌ فعال به روش نمونه‌گیری هدفمند انتخاب شدند. برنامه تمرینی شامل هشت هفته تمرین تناوبی با شدت متوسط 50 درصد ضربان قلب ذخیره بر اساس اصل اضافه‌بار بود. سطوح پلاسمایی پروتئین‌های سیرتوئین 1 و سیرتوئین 3، در دو مرحله پیش‌آزمون و پس‌آزمون مورد اندازه‌گیری قرار گرفت. جهت مقایسه پیش‌آزمون از آزمون تحلیل واریانس یک راهه (آنوا) و مقایسه پس‌آزمون دو گروه سالمند تمرین و سالمند کنترل از آزمون تحلیل کوواریانس استفاده شد.
نتایج: تجزیه و تحلیل داده‌ها نشان داد که سطوح پلاسمایی پروتئین‌های سیرتوئین 1 و سیرتوئین 3 در گروه‌های سالمند نسبت به گروه جوان به طور معنی‌داری کمتر بودند (05/0>P). همچنین بر اثر هشت هفته تمرین تناوبی سطوح پروتئین‌های فوق به طور معنی‌داری افزایش یافت (05/0>P).
نتیجه‌گیری: با توجه به نتایج پژوهش حاضر به نظر می‌رسد که تمرین تناوبی با شدت متوسط با افزایش پروتئین های sirt1 و sirt3، می‌تواند فشار اکسایشی ناشی از سالمندی را کاهش دهد و منجر به افزایش دفاع آنتی‌اکسیدانی و بهبود کیفیت زندگی سالمندان شود.

کلیدواژه‌ها

عنوان مقاله [English]

The effect of eight weeks of interval training on plasma levels of sirtuin 1 and sirtuin‌ 3 proteins in inactive elderly men

نویسندگان [English]

  • Raana Amiri
  • Fatemeh Makipour
  • mehdi bostani
Department of Physical Education, Islamic Azad University Ahvaz Branch, Ahvaz, Iran
چکیده [English]

Background and Objective: SIRT proteins are involved in the body's metabolic processes and homeostasis and are associated with oxidative stress due to aging and age-related diseases. Changes in these proteins in aging and the effect of physical activity on them have been less studied, so the aim of the present study was to investigate the effect of eight weeks of interval training on plasma levels of sirt1 and sirt3 proteins in inactive elderly men.
Materials and Methods: In this study, 20 inactive elderly men aged 70-60 years were selected by available sampling and divided into experimental and control groups by simple random sampling. To investigate the effect of aging on plasma levels of Sirt1 and Sirt3 proteins, 10 inactive young men were selected by purposive sampling. The training program consisted of eight weeks of interval training with a moderate intensity of 50% of the reserve heart rate based on the principle of overload. Plasma levels of Sirt1 and Sirt3 proteins were measured in two stages of pre-test and post-test. One-way analysis of variance (ANOVA) was used to compare the pre-test of the three groups and the analysis of covariance was used to compare the post-test of the two groups of training elderly and control elderly.
Results: The results showed that plasma levels of Sirt1 and Sirt3 proteins in the elderly group were significantly lower than the young group (P <0.05). Also, due to eight weeks of interval training, the levels of the above proteins increased significantly (P <0.05).
Conclusion: According to the results of this study, it seems that  moderate interval exercise with increasing the Sirt1 and Sirt3 proteins, can reduce the oxidative stress caused by aging and lead to increased antioxidant defense and improve the quality of life in the elderly.

کلیدواژه‌ها [English]

  • Interval Training
  • Aging
  • Sirtuin 1
  • Sirtuin 3

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دانشور پزشکی
دوره 30، شماره 4 - شماره پیاپی 161
مهر و آبان 1401
صفحه 62-73

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