تاثیر تمرین تناوبی با شدت بالا بر بیومارکرهای اتوفاژی عضله اسکلتی در رت های نر سالمند

نوع مقاله : مقاله پژوهشی

نویسندگان

دانشگاه آزاد اسلامی واحد بجنورد

10.22070/daneshmed.2021.12940.0

عنوان مقاله [English]

The effect of high intensity interval training on skeletal muscle autophagy biomarkers in elderly male rats

نویسندگان [English]

  • Saghar delshad
  • Ali yaghoubi
  • Najme rezaeian
چکیده [English]

Background and Objective. Autophagy plays an important role in the aging process. Exercise is known to be one of the most important modulators of aging, however the effects of high-intensity interval training (HIIT) on autophagy are less well known. Therefore, the aim of this study was to investigate the effect of HIIT on protein levels of ULK1, beclin1, sestrin 2 and AMPK in skeletal muscle of elderly rats.
Materials and Method. Twenty elderly male Wistar rats (18 months) were randomly divided into control (C) (10) and high intensity interval training (HIIT) (10) groups. After estimating the maximum speed, the training groups worked on the treadmill for 8 weeks, 3 sessions per week. Skeletal muscle tissue samples were extracted 48 hours after the last training session and independent t-test was used to analyze the data.
Results. HIIT resulted in a significant increase in protein levels of ULK1, beclin1, sestrin 2 and AMPK phosphorylation compared to the control group (P <0.05).
Conclusion. It seems that HIIT can play a regulatory role in autophagy and subsequent progression of changes associated with aging in the skeletal muscle of elderly rats through the sestrin 2 / AMPK pathway.

کلیدواژه‌ها [English]

  • Exercise training
  • Autophagy
  • Sestrin 2
  • elderly rat