عنوان مقاله [English]
نویسندگان [English]چکیده [English]
Background and Objective:Depression is one the five most common diseases in the world with a prevalence of 4.4% and Ustokhoddus is recommended for its treatment. This study was designed to determine the effects of Lavandula. officinalis extract on mouse model of reserpine induced depression.
Materials and Methods:Seventy-two mice were randomly divided into 9 groups: Normal saline, control extract (200 mg/kg), reserpine, fluoxetine (10 mg/kg or 20 mg/kg) + reserpine, fluoxetine (10 mg/kg) + extract (200 mg/kg) + reserpine, Three extract pretreated groups (100-200 and 400 mg/kg) + reserpine. Extract and fluoxetine were administrated by gavages daily, for 10 days, 30 min before reserpine (0.5 mg/kg) injection in peritoneal. Behavioral evaluations were done by forced swimming, tail suspension, elevated plus maze and open field tests.
Results: Immobility time was enhanced by reserpine (210.37 ± 2.43 in compared with normal saline 109.75 ± 3.13) and the extract decreased it, dose dependently (140.75± 5.84 and 110.125 ± 6.46 200 and 400 mg/kg respectively) as the same as fluoxetine (p < 0.05), in forced swimming test. Combination of extract and fluoxetine caused reduction of immobility time more effective than each one alone. The results obtained from tail suspension are similar to forced swimming test.
Conclusion: L. officinalis hydroalcoholic extract improved the depression like behavior caused by reserpine. The effect combination of the extract and fluoxetine was additive.