تأثیر تمرینات مقاومتی با و بدون تزریق ‌تستوسترون ‌بر سطوح ‌نسفاتین-1 پلاسمایی موش‌های ‌نر بالغ‌

نویسندگان

1 کارشناس‌ارشد فیزیولوژی ورزشی کاربردی، دانشکدۀ تربیت‌بدنی و علوم ورزشی، دانشگاه گیلان، رشت، ایران

2 کارشناس‌ارشد فیزیولوژی ورزشی، دانشکدۀ تربیت‌بدنی و علوم ورزشی، دانشگاه سیستان و بلوچستان، زاهدان، ایران

چکیده

مقدمه و هدف: نسفاتین-1 پپتید مؤثر در تنظیم تعادل انرژی است که بررسی تغییرات آن در اثر فعالیت بدنی، دارای اهمیت است. هدف پژوهش حاضر بررسی تأثیر تمرینات مقاومتی با و بدون تزریق ‌تستوسترون ‌بر سطوح ‌نسفاتین-1 پلاسمایی موش‌های ‌نر بالغ است.
 
مواد و روش‌ها: بدین منظور چهل سر موش با دامنۀ سنی تقریبی ده هفته، از نژاد ویستار با دامنۀ وزنی 205 تا 265 گرم به چهار گروه تقسیم شدند: گروه کنترل، گروه تستوسترون، گروه تمرین مقاومتی، گروه تمرین مقاومتی توأم با تزریق تستوسترون به‌صورت تصادفی. در گروه تستوسترون و گروه تمرین مقاومتی توأم با تزریق تستوسترون، سه روز در هفته یک میلی‌گرم به‌ازای هر کیلوگرم وزن بدن، تزریق تستوسترون انجام می‌شد. پروتکل تمرین مقاومتی شامل پنج جلسه تمرین در هفته (به‌مدت دوازده هفته) روی نردبان بود و موش‌ها باید ده تکرار را با وزنۀ موردنظر انجام می‌دادند.
 
نتایج: یافته‌ها ‌نشان می‌دهد که‌ مقادیر نسفاتین-1 در گروه ‌تمرین مقاومتی ‌و گروه تمرین مقاومتی توأم با تزریق تستوسترون ‌در مقایسه‌ با گروه ‌کنترل، ‌به‌‌طور‌ معنا‌داری ‌افزایش‌ یافته است (05/0>p < /span>). همچنین، ‌در گروه‌ تمرین‌ مقاومتی ‌در مقایسه ‌با گروه ‌تستوسترون، تغییرات معنا‌داری ‌در مقادیر نسفاتین- 1 مشاهده ‌شده است (05/0>p < /span>). بر خلاف آن، تغییرات مقادیر نسفاتین-1 در گروه تمرین‌ مقاومتی توأم با تزریق تستوسترون نسبت به گروه تستوسترون معنادار نبود (05/0˃p < /span>).
 
نتیجه‌گیری: نتایج پژوهش حاضر از سودمندی غیرقابل‌‌انکار تمرین مقاومتی در افزایش نسفاتین-1 حمایت می‌کند و تمرینات ورزشی را می‌توان برای تنظیم اشتها و انرژی مصرفی استفاده کرد. از آنجا که مطالعۀ حاضر از اولین پژوهش‌های انجام ‌شده درمورد اثر تمرینات ورزشی توأم با تزریق تستوسترون بر روی سطوح پلاسمایی نسفاتین-1 است، مطالعات بیشتری در این زمینه برای نتیجه‌گیری دقیق‌تر لازم است.

کلیدواژه‌ها


عنوان مقاله [English]

The effect of resistance training with and without testosterone injection on plasma levels of nesfatin-1 in adult male rats

نویسندگان [English]

  • Ehsan Eghbali 1
  • Seyede shiva Dadvand 1
  • Meysam Taheri 2
چکیده [English]

Background and Objective: Nesfatin-1 is an effective peptide in the regulation of energy balance. The aim of this research was investigation of the effects of resistance training with and without testosterone injection on plasma levels of nesfatin-1 in adult male rats.

Materials and Methods: For this purpose, 40 Wistar rats with a weight range of 205 to 265 g and aged approximately 10 weeks were randomly divided into four groups: control group, testosterone group, resistance training group, and resistance training with testosterone injections group. In testosterone group and resistance training with testosterone injections group, three times per week, 1 mg per kg body weight of testosterone was injected. Resistance training protocol was consisted of 5 sessions per week (for 12 weeks) on a ladder and rats performed 10 repetitions.

Results: Findings indicate that levels of nesfatin-1 in resistance training and resistance training with testosterone injection groups were significantly higher compared with control group (P˂0.05). Also, a significant change in levels of nesfatin-1 in the resistance training group compared with testosterone group (P˂0.05) was observed. In contrast, significant changes of nesfatin-1 in the resistance training with testosterone injections group was not observed compared to testosterone group (P˃0.05).
 
Conclusion: Results of this study support the undeniable benefits of resistance training for the increased nesfatin-1 and exercise can be used to regulate appetite and energy expenditure. Because the present study is the first research about the effects of exercise training with testosterone injections on plasma levels of nesfatin -1, more studies in this field are needed for more accurate conclusions. 

کلیدواژه‌ها [English]

  • Resistance training
  • Nesfatin-1
  • Testosterone
  • Rat
  • Adipose tissue
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