Volume 25, Issue 132 (1-2018)                   Daneshvar Medicine 2018, 25(132): 31-38 | Back to browse issues page

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Nasrollahi H, Gaeini A A, Biglari S, Ghardashi Afousi A. Changes of insulin-like growth factor I gene expression in gastrocnemius muscle of male Wistar rats after a period of high-intensity interval training. Daneshvar Medicine. 2018; 25 (132) :31-38
URL: http://daneshvarmed.shahed.ac.ir/article-1-1845-en.html
Department of Exercise Physiology, Faculty of Physical Education and Sports Sciences, University of Tehran, Tehran, Iran
Abstract:   (988 Views)
Background and Objective: Studies have shown that insulin-like growth factor (IGF-I) is the main factor of growth and hypertrophy of muscle fibers. However, the effect of high-intensity interval training (HIIT) on IGF-I has not been well studied. The purpose of the present study was to investigate the changes of IGF-I gene expression in gastrocnemius muscle of male Wistar rats after a period of high-intensity interval training.
 
Materials and Methods: In this research study, 16 male Wistar rats (mean weight: 225±25 g) were randomly assigned into two groups: training (n=8) and control (n=8). After a week of familiarizing with training protocol, HIIT program was done 40 minutes each session, three sessions in a week for eight weeks. Then, 48 hours after the last training session, gastrocnemius muscle was extracted and the expression of IGF-I gene was determined by Real time-PCR technique. For statistical data analysis, independent t-test was used.
 
Results: Statistical analysis showed that the value of gastrocnemius muscle IGF-I in the experimental group compared with the control group increased by more than 6 times (638%) (P=0.016). Gastrocnemius muscle weight was significantly increased in the exercise group compared with the control group (P=0.012).
 
Conclusion: HIIT exercise led to a marked increase in rats` IGF-I gene expression and gastrocnemius muscle weight.
 
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Type of Study: Research | Subject: فیزیولوژی ورزش

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