Volume 25, Issue 132 (1-2018)                   Daneshvar Medicine 2018, 25(132): 1-6 | Back to browse issues page

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Akbari H, Hasanzadeh S, Shalizar Jalali A, Malekinejad H. The effect of fluoxetine on spermatogenesis and spermatogonial stem cells self-renewal in adult male rats . Daneshvar Medicine. 2018; 25 (132) :1-6
URL: http://daneshvarmed.shahed.ac.ir/article-1-1841-en.html
Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
Abstract:   (1006 Views)
Background and Objective: Fluoxetine (FLX) application as a selective serotonin reuptake inhibitor (SSRI) drug that accompanies side effects including reproductive dysfunctions. The current study was designed to explore the effects of FLX on rat spermatogenesis as well as spermatogonial stem cells self-renewal through evaluation of glial cell line-derived neurotrophic factor  family receptor alpha-1 (GFRα1) expression at mRNA level in testicular tissue.
 
Materials and Methods: Adult male Wistar rats were randomly allocated into experimental and control groups. The experimental group was subdivided into two groups which received 5 mg/kg/day and 10 mg/kg/day of FLX orally for 48 days. Testicular tissue samples were collected 24 hours after the last treatment and histological assessments and reverse transcription polymerase chain reaction were done to analyze spermatogenesis and mRNA expression of GFRα1, respectively.
 
Results: Treatment with FLX caused spermatozoa maturation arrest in a dose-dependent manner as was evident by significant decreases in spermatogenic indices. Moreover, FLX administration at a dose of 10 mg/kg/day resulted in significant reduction in mRNA expression of GFRα1 in testicular tissue.
 
Conclusion: These findings suggest that FLX induces male reproductive toxicities via disruption of spermatogonial stem cells self-renewal, bringing about the necessity of more researches about the precise mechanisms of SSRI antidepressants-induced spermatogenic failures.
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Type of Study: Research | Subject: روانشناسی

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